Abstract:
BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin carcinoma. AIM:To investigate the function of key micro(mi)RNAs and to explore the potential molecular mechanisms involved in BCC. METHODS:The microarray dataset GSE34535, which comprises seven BCC samples and seven control samples, was downloaded from the Gene Expression Omnibus database. Differentially expressed miRNAs (DE-miRNAs) were identified. We collected tissue samples from 20 patients with BCC and 20 healthy controls (HCs), to compare the miR-18a expression in their tissue samples. Expression of miR-18a in A431 and HaCaT cells was also assayed. Following this, we upregulated and downregulated miR-18a expression in A431 cells to examine the effects on cell proliferation, migration and apoptosis. To further investigate the relative mechanism, the proteins LC3, Beclin 1, Akt and mammalian target of rapamycin (mTOR) were examined by quantitative real-time PCR and Western blotting. For further verification, we examined the expression of LC3 in the 20 BCC and 20 HC tissue samples. RESULTS:In total, 19 DE-miRNAs (13 upregulated and 6 downregulated) that were common to the BCC and HC groups were identified. Levels of miR-18a were about three-fold higher in BCC tissues and A431 cells compared with their respective control groups. In vitro, downregulation of miR-18a was shown to inhibit cell proliferation and activate autophagy via the Akt/mTOR signalling pathway, while upregulation of miR-18a promoted proliferation of these cells. LC3 was decreased in BCC compared with HC tissue samples. CONCLUSIONS:Our data support an oncogenic role of miR-18a through a novel Akt/mTOR/Beclin 1/LC3 axis, and suggest that the antitumour effects of miR-18a inhibitor may make it suitable for BCC therapy.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Mi X,Lai K,Yan L,Xie S,Qiu X,Xiao S,Wei Sdoi
10.1111/ced.14322subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1027-1034issue
8eissn
0307-6938issn
1365-2230journal_volume
45pub_type
杂志文章abstract::We report a patient with purely cutaneous Rosai-Dorfman disease (RDD) who presented with a solitary, asymptomatic plaque on the back of her left thigh, with characteristic, large histiocytoid cells exhibiting emperipolesis histologically. Cutaneous lesions occur in 27% of patients with lymph node involvement in RDD ho...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.1998.00312.x
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The dorsum of the hand is a common site for squamous cell carcinoma, and excision with appropriate margins often results in surgical defects that cannot be repaired by primary side-to-side closure. AIM:To assess healing time, complications and resulting scars when surgical wounds on the dorsum of the hand w...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12044
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abstract:BACKGROUND:Alopecia areata (AA) is an organ-specific autoimmune disease characterized by folliculotropic T-cell infiltrates around anagen-stage hair follicles. The role of T helper (Th)1 and Th2 cytokines in the pathogenesis of AA have not been established. AIM:To determine whether serum cytokine profiles define the s...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03523.x
更新日期:2010-06-01 00:00:00
abstract::Burning mouth syndrome is characterized by an idiopathic burning pain affecting the oral mucosa, with no clinically apparent changes. It can present to a variety of health professionals including dermatologists. This article summarizes the important aspects of the condition, including theories of pathogenesis, diagnos...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/ced.12808
更新日期:2016-03-01 00:00:00
abstract::Incipient osteomalacia developed in a Pakistani patient living in the UK after strict sunlight avoidance forming part of the management of the photosensitivity disorder, chronic actinic dermatitis. The patient's skin type and diet, which included calcium-binding phytates in chappattis, had increased his risk of the co...
journal_title:Clinical and experimental dermatology
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doi:10.1046/j.1365-2230.2000.00669.x
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2008.02924.x
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12512
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.13871
更新日期:2019-07-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2008.02888.x
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1993.tb02239.x
更新日期:1993-09-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1993.tb02221.x
更新日期:1993-07-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.2011.04256.x
更新日期:2012-04-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.13133
更新日期:2017-08-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.13769
更新日期:2019-06-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1994.tb01263.x
更新日期:1994-11-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.1994.tb01106.x
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Colonization of the skin of patients with atopic dermatitis (AD) by Staphylococcus aureus (SA) is associated with more severe disease. AIM:To determine the association of SA colonization patterns and densities in lesional and nonlesional skin in patients with varying severities of AD, and to determine the a...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2010.03962.x
更新日期:2011-03-01 00:00:00
abstract::Vitiligo usually begins in childhood with approximately half of the patients manifesting onset of disease prior to the age of 20 years. Treatment options in this age group are few and have disappointing response rates. This study was designed to evaluate the role of narrow-band UVB in the treatment of generalized viti...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2005.01837.x
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abstract:BACKGROUND:The protein kynureninase (KYNU) has recently been reported to participate in the pathological processes of various diseases. AIM:To explore the expression and the biological function of KYNU in cutaneous squamous cell carcinoma (cSCC). METHODS:Expression of KYNU in cSCC cell lines and tissues was firstly e...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.14072
更新日期:2020-03-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.13407
更新日期:2018-07-01 00:00:00
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journal_title:Clinical and experimental dermatology
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doi:10.1111/j.1365-2230.2004.01677.x
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2005.01722.x
更新日期:2005-05-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12331
更新日期:2014-06-01 00:00:00
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journal_title:Clinical and experimental dermatology
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doi:10.1046/j.1365-2230.1999.00395.x
更新日期:1999-01-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2005.01762.x
更新日期:2005-07-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1989.tb01993.x
更新日期:1989-07-01 00:00:00
abstract::Sarcoidosis is a rare disease among children, manifesting differently in children below and above 4-5 years of age. Although the exact incidence and prevalence of childhood sarcoidosis is not known, the cutaneous involvement is frequent in both children and adults. Infiltration of old cutaneous scars with sarcoid gran...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.2005.01727.x
更新日期:2005-05-01 00:00:00
abstract::Two patients presented with the unusual condition of multiple warty dyskeratomas on the scalp. Biopsies of affected skin stained positive with human keratin monoclonal antibodies HKN-6 and -7, specific for cortex and inner root sheath of normal human hair, respectively. Multiple warty dyskeratomas are a rare occurrenc...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::Ectodermal dysplasias (ED) are developmental disorders affecting tissues of ectodermal origin including hair, nail, teeth and sweat glands. To date, four different types of ectodermal dysplasias involving only hair and nails have been described. In an effort to understand the molecular basis of ED of hair and nails, a...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2007.02413.x
更新日期:2007-09-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03311.x
更新日期:2010-03-01 00:00:00