Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model.

Abstract:

:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.

journal_name

Clin Exp Dermatol

authors

Quartey QQ,Miller RJ,Pinsker BL,Okoh UJ,Shipman WD,George BA,Nwizu CC,Barnes LA,Kerns ML,Caffrey JA,Aliu O,Brown ID,Succaria F,Maynard JP,Herbert AS,Kang S,Miller LS,Okoye GA,Byrd AS

doi

10.1111/ced.14054

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

202-206

issue

2

eissn

0307-6938

issn

1365-2230

journal_volume

45

pub_type

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