Abstract:
:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Quartey QQ,Miller RJ,Pinsker BL,Okoh UJ,Shipman WD,George BA,Nwizu CC,Barnes LA,Kerns ML,Caffrey JA,Aliu O,Brown ID,Succaria F,Maynard JP,Herbert AS,Kang S,Miller LS,Okoye GA,Byrd ASdoi
10.1111/ced.14054subject
Has Abstractpub_date
2020-03-01 00:00:00pages
202-206issue
2eissn
0307-6938issn
1365-2230journal_volume
45pub_type
杂志文章abstract::Amyopathic dermatomyositis (ADM) is characterized clinically by typical skin lesions with hypomyopathy or no muscular involvement. ADM has been recently reported to be complicated by rapidly progressive interstitial lung disease (ILD), especially in patients with positive antibodies against melanoma differentiation-as...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12674
更新日期:2015-12-01 00:00:00
abstract::The linear pattern of lichen planus (LP) is extremely rare. In six publications 1256 patients with LP have been reviewed and only three cases of linear LP (LLP) are reported. The differential diagnosis of LLP includes a number of linear dermatoses in particular lichen striatus (LS) and the extent of overlap between th...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1993.tb02211.x
更新日期:1993-07-01 00:00:00
abstract::We performed an immunohistochemical study with 11 antikeratin antibodies using the newly developed AMeX (acetone-methylbenzoate-xylene) tissue processing method. Specimens processed with this method showed almost as good preservation and morphological detail as routinely processed, formalin-fixed and paraffin-embedded...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1994.tb01247.x
更新日期:1994-11-01 00:00:00
abstract::Three cases of chondrodermatitis nodularis helicis (CDNH) in patients with the limited form of systemic sclerosis are described. Two of the three cases were noted during regular follow-up visits and the third case was found as part of a survey of the 21 other patients with systemic sclerosis routinely seen in the depa...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1994.tb01169.x
更新日期:1994-05-01 00:00:00
abstract::The clinical and histological effects of retinyl propionate cream (a retinyl ester) on extrinsic skin ageing (photo-ageing) in man were assessed in a double-blind randomized placebo-controlled study of 80 subjects, individual parameters of this being assessed for each treatment site (face, dorsal right forearm and han...
journal_title:Clinical and experimental dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2230.1998.00331.x
更新日期:1998-07-01 00:00:00
abstract::It is well known that systemic corticosteroids arrest the progress of vitiligo and lead to repigmentation, but they may produce unacceptable side-effects. The use of high-dose prednisolone therapy to minimize the side-effects of systemic steroids has been reported, but there have been no reports on the effectiveness o...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2007.02387.x
更新日期:2007-09-01 00:00:00
abstract::A 65-year-old female suffered trauma to her left hand on which acrodermatitis continua (psoriasis of Hallopeau) developed. It is suggested that the persistent pain of this skin condition, its poor response to treatment and her allied mental state led to the development of a severe algodystrophy with marked underlying ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1989.tb02609.x
更新日期:1989-11-01 00:00:00
abstract::The Laugier-Hunziker syndrome is an acquired, benign, macular hyperpigmentation of the lips and buccal mucosa. The nails are often involved with the development of melanonychia. Twenty-two previous cases have been recorded in the literature. We present details of six Caucasian patients with the Laugier-Hunziker syndro...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1990.tb02044.x
更新日期:1990-03-01 00:00:00
abstract::Three children (two boys and one girl) from the same family presented with photosensitivity, hyperpigmentation, hypertrichosis, mild skin fragility, blistering and scarring in childhood. On examination, the cutaneous lesions were found to have improved since their previous examinations. Laboratory tests showed raised ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2008.02734.x
更新日期:2008-08-01 00:00:00
abstract::We describe an 18-year-old girl with systemic lupus erythematosus (SLE) who had cutaneous papulonodular mucinosis (PNM) as the first sign of SLE. She presented with multiple flesh-coloured papules on the face, abdomen and limbs. Histological examination of a biopsy taken from a papule showed diffuse deposition of muci...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03235.x
更新日期:2009-12-01 00:00:00
abstract::Pityriasis rotunda (PR) is an uncommon chronic dermatosis, which may be idiopathic or may be associated with infections or malignancy. We describe the clinical and biochemical findings of two patients with multiple myeloma, who were incidentally diagnosed with PR, and detail the clinical conditions with which this rar...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12396
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Vitiligo is an acquired pigmentation disorder, which can have a negative effect on patient quality of life (QoL). AIM:To evaluate QoL and psychiatric comorbidity in paediatric patients with vitiligo. METHODS:In total, 30 patients aged 8-18 years who were diagnosed with vitiligo and 30 age- and sex-matched ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.14196
更新日期:2020-02-16 00:00:00
abstract::In this study we used the nickel contact allergy patch (CAP) test to investigate the effect of topical corticosteroids on allergic contact dermatitis (ACD). On day 1, three CAP tests were applied for 48 h on the forearms of 20 female volunteers with a known nickel ACD. CAP of the right forearm contained 5% nickel, and...
journal_title:Clinical and experimental dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.0307-6938.2001.00963.x
更新日期:2002-01-01 00:00:00
abstract::Dapsone has potent anti-inflammatory effects, and is used in the treatment of leprosy, cutaneous vasculitis, neutrophilic dermatoses, and dermatitis herpetiformis and other blistering disorders. However, it may cause severe adverse reactions such as hypersensitivity syndrome, which is characterized by fever, skin rash...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03527.x
更新日期:2009-12-01 00:00:00
abstract::Cutaneous drug eruptions have a variety of clinical features. Lichenoid drug eruptions are rare and may be difficult to diagnose. A case of a simvastatin-induced lichenoid eruption with skin and mucosal involvement is reported. ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1994.tb01128.x
更新日期:1994-01-01 00:00:00
abstract::Pyostomatitis vegetans is a rare oral disorder often associated with gastrointestinal and/or cutaneous diseases and sometimes with other disorders. The association of pyostomatitis vegetans with inflammatory bowel disease, particularly ulcerative colitis, is well known and in most cases bowel disease precedes the onse...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.2004.01438.x
更新日期:2004-01-01 00:00:00
abstract::Steatocystoma multiplex is a rare, autosomal dominant condition characterized by multiple cysts, usually arising on the trunk and proximal extremities at puberty. We present two unrelated women with sporadic steatocystoma multiplex strictly confined to the vulva and arising at an older age. These cases represent an un...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.2002.01027.x
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Studies have found that the interleukin-23/T helper 17 (IL-23/Th17) pathway plays an important role in the pathogenesis of atopic dermatitis (AD). Inhibition of the IL-23/Th17 pathway with monoclonal antibodies reduces skin inflammation in animal models. AIM:To investigate the association between IL-17A a...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12438
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Tinea unguium is a dermatophyte infection of the nails. Itraconazole is a broad-spectrum antifungal drug used to treat this disease. It works by interfering with the synthesis of ergosterol in the cell membrane, thus causing changes that can be seen under scanning electron microscopy (SEM). AIM:To observe u...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.13641
更新日期:2018-12-01 00:00:00
abstract::In Europe and the USA, the incidence of primary nasal natural killer (NK)/T-cell lymphoma is rare. The skin is one of the predilection sites for dissemination. Cutaneous dissemination is a poor prognostic sign and is consistently fatal. We describe the case of a 17-year-old white German girl with a primary nasal NK/T-...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2008.02777.x
更新日期:2008-08-01 00:00:00
abstract::This review provides a summary of key findings from 24 systematic reviews of atopic eczema (AE) published or indexed between 1 August 2010 and 31 December 2011, updating published summaries from previous years. Epidemiological evidence points to the protective effects of early daycare, endotoxin exposure, consumption ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/ced.12143
更新日期:2013-07-01 00:00:00
abstract::Systemic sclerosis (SSc) is often complicated by severe skin ulcers that are unresponsive to traditional treatments. Vascular alterations are responsible for the ischaemic features of the disease in both the skin and visceral organs. Defective neoangiogenesis correlates with an abnormally reduced quantity of circulati...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2010.03847.x
更新日期:2010-12-01 00:00:00
abstract::Myiasis is a condition resulting from the invasion of tissues or organs of man or animals by the larvae of dipterous flies. The distribution of myiasis is worldwide, with more cases being reported from tropical, subtropical, and warm temperate areas. The various forms of myiasis may be classified from an entomological...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.1999.00479.x
更新日期:1999-07-01 00:00:00
abstract::We present the case of a 68-year-old woman who developed a painful subcutaneous tumour in the sacral region. Histological examinations revealed a characteristic zonal pattern with a central zone of liquefactive necrosis, surrounded by proliferated atypical fibroblasts and prominent vessels, indicating ischaemic fascii...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12834
更新日期:2016-07-01 00:00:00
abstract::We report 20 patients who contracted cutaneous leishmaniasis in Central and South America, 18 of them in Belize. The diagnosis was confirmed by the polymerase chain reaction (PCR) in 79% of those tested; the corresponding figure for histology was 62%, touch smear 46%, and culture 11%. Results of PCR can be falsely pos...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.2001.00751.x
更新日期:2001-01-01 00:00:00
abstract::A 69-year-old woman presented with a nonhealing ulcer on her right cheek. On histological examination of a biopsy, no evidence of granuloma formation or malignancy was found, and the overall picture was felt to be consistent with dermatitis artefacta (DA). The patient was referred to a joint psychodermatology clinic, ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2012.04448.x
更新日期:2013-07-01 00:00:00
abstract::Necrobiosis lipoidica is a well recognized but comparatively rare cutaneous complication of diabetes mellitus. The aetiology is probably multifactorial with microangiopathy, immune complex formation, abnormal collagen synthesis and breakdown, and altered haemostasis all thought to play a part. Necrobiosis lipoidica of...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.2001.00789.x
更新日期:2001-03-01 00:00:00
abstract::This is the first of two articles on C1 inhibitor deficiency based on a recent UK consensus document covering diagnosis and management of the disorder in both adults and children. This paper focuses on diagnosis of this disorder. ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.2005.01829.x
更新日期:2005-07-01 00:00:00
abstract::Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare lichenoid dermatosis defined by scarring alopecia, loss of pubic and axillary hairs and progressive development of horny follicular papules variously located. Topical or systemic corticosteroids, retinoids or PUVA therapy are the treatments usually proposed an...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.2001.00881.x
更新日期:2001-09-01 00:00:00
abstract::Loceryl nail lacquer was developed to provide the effective antifungal drug, amorolfine, in a once-weekly dosage regimen combined with a convenient mode of application. Traditional formulations such as creams and nail solutions do not fulfil these requirements because they are wiped or washed off very rapidly. Amorolf...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1992.tb00273.x
更新日期:1992-09-01 00:00:00