Abstract:
:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Quartey QQ,Miller RJ,Pinsker BL,Okoh UJ,Shipman WD,George BA,Nwizu CC,Barnes LA,Kerns ML,Caffrey JA,Aliu O,Brown ID,Succaria F,Maynard JP,Herbert AS,Kang S,Miller LS,Okoye GA,Byrd ASdoi
10.1111/ced.14054subject
Has Abstractpub_date
2020-03-01 00:00:00pages
202-206issue
2eissn
0307-6938issn
1365-2230journal_volume
45pub_type
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