Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model.


:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.


Clin Exp Dermatol


Quartey QQ,Miller RJ,Pinsker BL,Okoh UJ,Shipman WD,George BA,Nwizu CC,Barnes LA,Kerns ML,Caffrey JA,Aliu O,Brown ID,Succaria F,Maynard JP,Herbert AS,Kang S,Miller LS,Okoye GA,Byrd AS




Has Abstract


2020-03-01 00:00:00












  • Amyophatic dermatomyositis presenting as a flagellated skin eruption with positive MDA5 antibodies and thyroid cancer: a real association?

    abstract::Amyopathic dermatomyositis (ADM) is characterized clinically by typical skin lesions with hypomyopathy or no muscular involvement. ADM has been recently reported to be complicated by rapidly progressive interstitial lung disease (ILD), especially in patients with positive antibodies against melanoma differentiation-as...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Molina-Ruiz AM,Romero F,Carrasco L,Feltes F,Haro R,Requena L

    更新日期:2015-12-01 00:00:00

  • Linear lichen planus and lichen striatus--opposite ends of a spectrum.

    abstract::The linear pattern of lichen planus (LP) is extremely rare. In six publications 1256 patients with LP have been reviewed and only three cases of linear LP (LLP) are reported. The differential diagnosis of LLP includes a number of linear dermatoses in particular lichen striatus (LS) and the extent of overlap between th...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Herd RM,McLaren KM,Aldridge RD

    更新日期:1993-07-01 00:00:00

  • Usefulness of the AMeX method for immunostaining with antikeratin antibodies.

    abstract::We performed an immunohistochemical study with 11 antikeratin antibodies using the newly developed AMeX (acetone-methylbenzoate-xylene) tissue processing method. Specimens processed with this method showed almost as good preservation and morphological detail as routinely processed, formalin-fixed and paraffin-embedded...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ansai SI,Koseki S,Hozumi Y,Kondo S

    更新日期:1994-11-01 00:00:00

  • Chondrodermatitis nodularis helicis occurring with systemic sclerosis--an under-reported association?

    abstract::Three cases of chondrodermatitis nodularis helicis (CDNH) in patients with the limited form of systemic sclerosis are described. Two of the three cases were noted during regular follow-up visits and the third case was found as part of a survey of the 21 other patients with systemic sclerosis routinely seen in the depa...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Bottomley WW,Goodfield MD

    更新日期:1994-05-01 00:00:00

  • A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing.

    abstract::The clinical and histological effects of retinyl propionate cream (a retinyl ester) on extrinsic skin ageing (photo-ageing) in man were assessed in a double-blind randomized placebo-controlled study of 80 subjects, individual parameters of this being assessed for each treatment site (face, dorsal right forearm and han...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Green C,Orchard G,Cerio R,Hawk JL

    更新日期:1998-07-01 00:00:00

  • High-dose prednisolone and psoralen ultraviolet A combination therapy in 36 patients with vitiligo.

    abstract::It is well known that systemic corticosteroids arrest the progress of vitiligo and lead to repigmentation, but they may produce unacceptable side-effects. The use of high-dose prednisolone therapy to minimize the side-effects of systemic steroids has been reported, but there have been no reports on the effectiveness o...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Lee Y,Seo YJ,Lee JH,Park JK

    更新日期:2007-09-01 00:00:00

  • Algodystrophy (reflex sympathetic dystrophy) complicating unilateral acrodermatitis continua.

    abstract::A 65-year-old female suffered trauma to her left hand on which acrodermatitis continua (psoriasis of Hallopeau) developed. It is suggested that the persistent pain of this skin condition, its poor response to treatment and her allied mental state led to the development of a severe algodystrophy with marked underlying ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Stephens CJ,McGibbon DH

    更新日期:1989-11-01 00:00:00

  • The Laugier-Hunziker syndrome--a clinical review of six cases.

    abstract::The Laugier-Hunziker syndrome is an acquired, benign, macular hyperpigmentation of the lips and buccal mucosa. The nails are often involved with the development of melanonychia. Twenty-two previous cases have been recorded in the literature. We present details of six Caucasian patients with the Laugier-Hunziker syndro...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Kemmett D,Ellis J,Spencer MJ,Hunter JA

    更新日期:1990-03-01 00:00:00

  • Childhood-onset mild cutaneous porphyria with compound heterozygotic mutations in the uroporphyrinogen decarboxylase gene.

    abstract::Three children (two boys and one girl) from the same family presented with photosensitivity, hyperpigmentation, hypertrichosis, mild skin fragility, blistering and scarring in childhood. On examination, the cutaneous lesions were found to have improved since their previous examinations. Laboratory tests showed raised ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Remenyik E,Lecha M,Badenas C,Kószó F,Vass V,Herrero C,Varga V,Emri G,Balogh A,Horkay I

    更新日期:2008-08-01 00:00:00

  • Papulonodular mucinosis indicating systemic lupus erythematosus.

    abstract::We describe an 18-year-old girl with systemic lupus erythematosus (SLE) who had cutaneous papulonodular mucinosis (PNM) as the first sign of SLE. She presented with multiple flesh-coloured papules on the face, abdomen and limbs. Histological examination of a biopsy taken from a papule showed diffuse deposition of muci...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Shekari AM,Ghiasi M,Ghasemi E,Kani ZA

    更新日期:2009-12-01 00:00:00

  • Pityriasis rotunda as an incidental paraneoplastic finding in two patients with multiple myeloma.

    abstract::Pityriasis rotunda (PR) is an uncommon chronic dermatosis, which may be idiopathic or may be associated with infections or malignancy. We describe the clinical and biochemical findings of two patients with multiple myeloma, who were incidentally diagnosed with PR, and detail the clinical conditions with which this rar...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: van Heerden T,Webb MJ,Barrett CL

    更新日期:2014-08-01 00:00:00

  • Quality of life, emotion dysregulation, attention deficit and psychiatric comorbidity in children and adolescents with vitiligo.

    abstract:BACKGROUND:Vitiligo is an acquired pigmentation disorder, which can have a negative effect on patient quality of life (QoL). AIM:To evaluate QoL and psychiatric comorbidity in paediatric patients with vitiligo. METHODS:In total, 30 patients aged 8-18 years who were diagnosed with vitiligo and 30 age- and sex-matched ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ucuz I,Altunisik N,Sener S,Turkmen D,Kavuran NA,Marsak M,Colak C

    更新日期:2020-02-16 00:00:00

  • Efficacy of topical corticosteroids in nickel-induced contact allergy.

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    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hachem JP,De Paepe K,Vanpée E,Bogaerts M,Kaufman L,Rogiers V,Roseeuw D

    更新日期:2002-01-01 00:00:00

  • Dapsone hypersensitivity syndrome with circulating 190-kDa and 230-kDa autoantibodies.

    abstract::Dapsone has potent anti-inflammatory effects, and is used in the treatment of leprosy, cutaneous vasculitis, neutrophilic dermatoses, and dermatitis herpetiformis and other blistering disorders. However, it may cause severe adverse reactions such as hypersensitivity syndrome, which is characterized by fever, skin rash...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Chun JS,Yun SJ,Kim SJ,Lee SC,Won YH,Lee JB

    更新日期:2009-12-01 00:00:00

  • Simvastatin-induced lichenoid drug eruption.

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Roger D,Rolle F,Labrousse F,Brosset A,Bonnetblanc JM

    更新日期:1994-01-01 00:00:00

  • Pyostomatitis vegetans.

    abstract::Pyostomatitis vegetans is a rare oral disorder often associated with gastrointestinal and/or cutaneous diseases and sometimes with other disorders. The association of pyostomatitis vegetans with inflammatory bowel disease, particularly ulcerative colitis, is well known and in most cases bowel disease precedes the onse...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Hegarty AM,Barrett AW,Scully C

    更新日期:2004-01-01 00:00:00

  • Late onset vulvar steatocystoma multiplex.

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Rongioletti F,Cattarini G,Romanelli P

    更新日期:2002-09-01 00:00:00

  • The A/A genotype of an interleukin-17A polymorphism predisposes to increased severity of atopic dermatitis and coexistence with asthma.

    abstract:INTRODUCTION:Studies have found that the interleukin-23/T helper 17 (IL-23/Th17) pathway plays an important role in the pathogenesis of atopic dermatitis (AD). Inhibition of the IL-23/Th17 pathway with monoclonal antibodies reduces skin inflammation in animal models. AIM:To investigate the association between IL-17A a...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Narbutt J,Wojtczak M,Zalińska A,Salinski A,Przybylowska-Sygut K,Kuna P,Majak P,Sysa-Jedrzejowska A,Lesiak A

    更新日期:2015-01-01 00:00:00

  • Ultrastructural changes of Trichophyton rubrum in tinea unguium after itraconazole therapy in vivo observed using scanning electron microscopy.

    abstract:BACKGROUND:Tinea unguium is a dermatophyte infection of the nails. Itraconazole is a broad-spectrum antifungal drug used to treat this disease. It works by interfering with the synthesis of ergosterol in the cell membrane, thus causing changes that can be seen under scanning electron microscopy (SEM). AIM:To observe u...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Yue X,Wang A,Sun Y,Li Q

    更新日期:2018-12-01 00:00:00

  • Cutaneous dissemination of nasal NK/T-cell lymphoma in a young girl.

    abstract::In Europe and the USA, the incidence of primary nasal natural killer (NK)/T-cell lymphoma is rare. The skin is one of the predilection sites for dissemination. Cutaneous dissemination is a poor prognostic sign and is consistently fatal. We describe the case of a 17-year-old white German girl with a primary nasal NK/T-...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Sandner A,Helmbold P,Winkler M,Gattenlöhner S,Müller-Hermelink HK,Holzhausen HJ

    更新日期:2008-08-01 00:00:00

  • What's new in atopic eczema? An analysis of systematic reviews published in 2010-11.

    abstract::This review provides a summary of key findings from 24 systematic reviews of atopic eczema (AE) published or indexed between 1 August 2010 and 31 December 2011, updating published summaries from previous years. Epidemiological evidence points to the protective effects of early daycare, endotoxin exposure, consumption ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Torley D,Futamura M,Williams HC,Thomas KS

    更新日期:2013-07-01 00:00:00

  • Recombinant human erythropoietin stimulates vasculogenesis and wound healing in a patient with systemic sclerosis complicated by severe skin ulcers.

    abstract::Systemic sclerosis (SSc) is often complicated by severe skin ulcers that are unresponsive to traditional treatments. Vascular alterations are responsible for the ischaemic features of the disease in both the skin and visceral organs. Defective neoangiogenesis correlates with an abnormally reduced quantity of circulati...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ferri C,Giuggioli D,Manfredi A,Quirici N,Scavullo C,Colaci M,Gianelli U,Deliliers GL,Del Papa N

    更新日期:2010-12-01 00:00:00

  • Vulvar myiasis due to Wohlfahrtia magnifica.

    abstract::Myiasis is a condition resulting from the invasion of tissues or organs of man or animals by the larvae of dipterous flies. The distribution of myiasis is worldwide, with more cases being reported from tropical, subtropical, and warm temperate areas. The various forms of myiasis may be classified from an entomological...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Delir S,Handjani F,Emad M,Ardehali S

    更新日期:1999-07-01 00:00:00

  • Usefulness of ultrasonography in the diagnosis of ischaemic fasciitis.

    abstract::We present the case of a 68-year-old woman who developed a painful subcutaneous tumour in the sacral region. Histological examinations revealed a characteristic zonal pattern with a central zone of liquefactive necrosis, surrounded by proliferated atypical fibroblasts and prominent vessels, indicating ischaemic fascii...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Kaneko T,Rokunohe D,Takiyoshi N,Minakawa S,Nakano H,Sawamura D

    更新日期:2016-07-01 00:00:00

  • The management of cutaneous leishmaniasis from Belize.

    abstract::We report 20 patients who contracted cutaneous leishmaniasis in Central and South America, 18 of them in Belize. The diagnosis was confirmed by the polymerase chain reaction (PCR) in 79% of those tested; the corresponding figure for histology was 62%, touch smear 46%, and culture 11%. Results of PCR can be falsely pos...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Palmer RA,Tran D,Hepburn NC,Ashton RE

    更新日期:2001-01-01 00:00:00

  • Facial ulcer treated with olanzapine.

    abstract::A 69-year-old woman presented with a nonhealing ulcer on her right cheek. On histological examination of a biopsy, no evidence of granuloma formation or malignancy was found, and the overall picture was felt to be consistent with dermatitis artefacta (DA). The patient was referred to a joint psychodermatology clinic, ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Lowry CL,Bewley A,Taylor R

    更新日期:2013-07-01 00:00:00

  • Tissue-engineered dermal skin grafting in the treatment of ulcerated necrobiosis lipoidica.

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Owen CM,Murphy H,Yates VM

    更新日期:2001-03-01 00:00:00

  • C1 inhibitor deficiency: diagnosis.

    abstract::This is the first of two articles on C1 inhibitor deficiency based on a recent UK consensus document covering diagnosis and management of the disorder in both adults and children. This paper focuses on diagnosis of this disorder. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Gompels MM,Lock RJ

    更新日期:2005-07-01 00:00:00

  • Graham Little-Piccardi-Lassueur syndrome: effective treatment with cyclosporin A.

    abstract::Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare lichenoid dermatosis defined by scarring alopecia, loss of pubic and axillary hairs and progressive development of horny follicular papules variously located. Topical or systemic corticosteroids, retinoids or PUVA therapy are the treatments usually proposed an...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Bianchi L,Paro Vidolin A,Piemonte P,Carboni I,Chimenti S

    更新日期:2001-09-01 00:00:00

  • Loceryl nail lacquer--realization of a new galenical approach to onychomycosis therapy.

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Pittrof F,Gerhards J,Erni W,Klecak G

    更新日期:1992-09-01 00:00:00