Abstract:
:Urticarial vasculitis (UV) is a mainly leucocytoclastic vasculitis with urticarial plaques. Treating these patients is challenging as the available treatments have poor efficacy. Oral corticosteroids are considered the first-line treatment, but H1 antihistamines, dapsone, colchicine, antimalarials, ciclosporin and antileucotrienes have all been tried also. However, because of their adverse effects and/or lack of efficacy, new agents are still needed. Omalizumab, an anti-IgE antibody, shows efficacy in chronic spontaneous urticaria, and might also be a good treatment for angio-oedema and urticarial vasculitis. To our knowledge, there have been only seven relevant case reports published in the English literature. We add a new case of severe chronic recurrent urticarial vasculitis refractory to all of the drugs mentioned above. We started the patient on subcutaneous omalizumab 300 mg every 4 weeks, which produced clinical improvement within the first month and total remission in the fifth month. The patient has remained stable for 23 months, and follow-up is ongoing.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Fueyo-Casado A,Campos-Muñoz L,González-Guerra E,Pedraz-Muñoz J,Cortés-Toro JA,López-Bran Edoi
10.1111/ced.13076subject
Has Abstractpub_date
2017-06-01 00:00:00pages
403-405issue
4eissn
0307-6938issn
1365-2230journal_volume
42pub_type
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