Allergic reactions to glyceryl trinitrate and isosorbide dinitrate demonstrating cross-sensitivity.

Abstract:

:Glyceryl trinitrate (nitroglycerin) has been in use for relief of angina for over a hundred years, but allergic reactions to it or to other organic nitrates rarely feature in the medical literature. Most of the case reports describe reactions to transdermally applied nitroglycerin. We report a case of a localized allergic reaction to nitroglycerin transdermal patches that developed when these were worn for the first time after 7 days of uneventful treatment with intravenous isosorbide dinitrate. The reaction evolved into a severe and generalized maculopapular rash with facial swelling when intravenous isosorbide dinitrate was re-administered 10 days later. Subsequent patch testing with a transdermal nitroglycerin patch and a placebo nitroglycerin-free patch provoked a reaction to the nitroglycerin patch but not to the placebo, thus excluding allergy to other constituents of the nitroglycerin patch.

journal_name

Clin Exp Dermatol

authors

Aquilina S,Felice H,Boffa MJ

doi

10.1046/j.1365-2230.2002.01165.x

keywords:

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

700-2

issue

8

eissn

0307-6938

issn

1365-2230

pii

1165

journal_volume

27

pub_type

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