Abstract:
:Ninety-six patients with a clinical and parasitological diagnosis of cutaneous leishmaniasis were recruited to a comparative randomized clinical trial evaluating the efficacy of topical paromomycin vs. weekly intralesional injections of meglumine antimoniate. The patients were randomly divided into two treatment groups: one group was treated with topical paromomycin ointment and the other with intralesional meglumine antimoniate. Treatment was continued in both groups until complete recovery occurred (defined as healing in less than 2 months with no residual scar or relapse for up to 1 year post treatment). Treatment failure was defined as an increase in the number and size of pre-existing lesions or untoward side-effects. The maximum treatment period was 3 months. The patients were followed up for 1 year. The results showed that intralesional meglumine antimoniate led to 41.7% complete recovery, However, topical paromomycin gave a lower cure rate of 16.6% (P < 0.05). Treatment failure was observed in 39.7% of the group receiving intralesional meglumine and in 72.9% of those on topical paromomycin (P < 0.05). This study indicates that intralesional meglumine antimoniate is superior to topical paromomycin in the treatment of cutaneous leishmaniasis.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Faghihi G,Tavakoli-kia Rdoi
10.1046/j.1365-2230.2003.01169.xkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
13-6issue
1eissn
0307-6938issn
1365-2230pii
1169journal_volume
28pub_type
临床试验,杂志文章,随机对照试验abstract::We report the cases of two patients who developed generalized pustular psoriasis on the withdrawal of oral Cyclosporin treatment for persistent palmoplantar pustulosis. This complication does not appear to have been reported previously. ...
journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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