Treatment of cutaneous leishmaniasis with either topical paromomycin or intralesional meglumine antimoniate.

Abstract:

:Ninety-six patients with a clinical and parasitological diagnosis of cutaneous leishmaniasis were recruited to a comparative randomized clinical trial evaluating the efficacy of topical paromomycin vs. weekly intralesional injections of meglumine antimoniate. The patients were randomly divided into two treatment groups: one group was treated with topical paromomycin ointment and the other with intralesional meglumine antimoniate. Treatment was continued in both groups until complete recovery occurred (defined as healing in less than 2 months with no residual scar or relapse for up to 1 year post treatment). Treatment failure was defined as an increase in the number and size of pre-existing lesions or untoward side-effects. The maximum treatment period was 3 months. The patients were followed up for 1 year. The results showed that intralesional meglumine antimoniate led to 41.7% complete recovery, However, topical paromomycin gave a lower cure rate of 16.6% (P < 0.05). Treatment failure was observed in 39.7% of the group receiving intralesional meglumine and in 72.9% of those on topical paromomycin (P < 0.05). This study indicates that intralesional meglumine antimoniate is superior to topical paromomycin in the treatment of cutaneous leishmaniasis.

journal_name

Clin Exp Dermatol

authors

Faghihi G,Tavakoli-kia R

doi

10.1046/j.1365-2230.2003.01169.x

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

13-6

issue

1

eissn

0307-6938

issn

1365-2230

pii

1169

journal_volume

28

pub_type

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