Abstract:
:We report a case of drug reaction with eosinophilia and systemic symptoms (DRESS) to efalizumab. A 52-year-old man developed a widespread papulovesicular rash after 4 weeks of treatment with efalizumab (1.0 mg/kg/week) for treatment-resistant severe psoriasis. Histology revealed a subepidermal blister with eosinophil-rich inflammatory cell infiltrate. Subsequently, the patient developed high peripheral eosinophilia, abnormal liver function, malaise and fever, all requiring inpatient admission. Efalizumab was discontinued immediately, but the rash persisted for 4 months and was only controlled by oral prednisolone at a dose of 30 mg/day. To our knowledge, this is the first reported case of DRESS caused by efalizumab.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
White JM,Smith CH,Robson A,Ash G,Barker JNdoi
10.1111/j.1365-2230.2007.02604.xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
50-2issue
1eissn
0307-6938issn
1365-2230pii
CED2604journal_volume
33pub_type
杂志文章abstract::We describe a combined cutaneous hamartoma in a 57-year-old man, which comprised a vellus hair cyst, an epidermoid cyst and an intradermal melanocytic naevus in a single facial tumour. The vellus hair cyst was filled with keratinous material with unusual slit-like lacunae. While numerous cases of epidermoid cyst have ...
journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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abstract::Sarcoidosis is a rare disease among children, manifesting differently in children below and above 4-5 years of age. Although the exact incidence and prevalence of childhood sarcoidosis is not known, the cutaneous involvement is frequent in both children and adults. Infiltration of old cutaneous scars with sarcoid gran...
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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