DRESS syndrome caused by efalizumab.

Abstract:

:We report a case of drug reaction with eosinophilia and systemic symptoms (DRESS) to efalizumab. A 52-year-old man developed a widespread papulovesicular rash after 4 weeks of treatment with efalizumab (1.0 mg/kg/week) for treatment-resistant severe psoriasis. Histology revealed a subepidermal blister with eosinophil-rich inflammatory cell infiltrate. Subsequently, the patient developed high peripheral eosinophilia, abnormal liver function, malaise and fever, all requiring inpatient admission. Efalizumab was discontinued immediately, but the rash persisted for 4 months and was only controlled by oral prednisolone at a dose of 30 mg/day. To our knowledge, this is the first reported case of DRESS caused by efalizumab.

journal_name

Clin Exp Dermatol

authors

White JM,Smith CH,Robson A,Ash G,Barker JN

doi

10.1111/j.1365-2230.2007.02604.x

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

50-2

issue

1

eissn

0307-6938

issn

1365-2230

pii

CED2604

journal_volume

33

pub_type

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