Dyschromatosis universalis hereditaria.

Abstract:

:Dyschromatosis universalis hereditaria is a clinically heterogenous disorder. We report two unrelated Indian patients with dyschromatosis universalis hereditaria, who had generalized and progressive reticulate hyper- and hypo-pigmentation of the skin. The oral mucosa and tongue also showed mottled pigmentation. Intriguingly, the palms and soles were also affected with a diffuse hyper-pigmentation interspersed with spotty de-pigmented macules. Dystrophic nail changes with pterygium formation were seen in one case. Histopathology revealed a variable degree of pigmentary incontinence. Although the precise aetiology of this disorder is not yet known, the clinicopathological findings implicate an inherent abnormality of melanosomes or melanin processing.

journal_name

Clin Exp Dermatol

authors

Sethuraman G,Srinivas CR,D'Souza M,Thappa DM,Smiles L

doi

10.1046/j.1365-2230.2002.01129.x

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

477-9

issue

6

eissn

0307-6938

issn

1365-2230

pii

1129

journal_volume

27

pub_type

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