Abstract:
:Dyschromatosis universalis hereditaria is a clinically heterogenous disorder. We report two unrelated Indian patients with dyschromatosis universalis hereditaria, who had generalized and progressive reticulate hyper- and hypo-pigmentation of the skin. The oral mucosa and tongue also showed mottled pigmentation. Intriguingly, the palms and soles were also affected with a diffuse hyper-pigmentation interspersed with spotty de-pigmented macules. Dystrophic nail changes with pterygium formation were seen in one case. Histopathology revealed a variable degree of pigmentary incontinence. Although the precise aetiology of this disorder is not yet known, the clinicopathological findings implicate an inherent abnormality of melanosomes or melanin processing.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Sethuraman G,Srinivas CR,D'Souza M,Thappa DM,Smiles Ldoi
10.1046/j.1365-2230.2002.01129.xkeywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
477-9issue
6eissn
0307-6938issn
1365-2230pii
1129journal_volume
27pub_type
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