T-cell receptor gene analysis in cutaneous T-cell lymphomas.

Abstract:

:An essential property of the immune system is its ability to generate diverse antibody and T-cell mediated responses to virtually any potential foreign particle. The basic molecular mechanisms responsible for producing this extensive diversity have now been elucidated. Each T cell expresses a unique membrane bound T-cell antigen receptor (TCR) which combines with specific antigenic peptides and major histocompatibility complex molecules. The characterization of TCR usage now represents a focal point for many studies of inflammatory and neoplastic disorders. Such studies are helping to clarify the pathogenesis of T-cell mediated diseases and provide the basis for the development of specific therapies. This paper will review several techniques used to identify neoplastic T-cell clones in cutaneous T-cell lymphoma. Similar methods may be used to analyse TCR gene usage in cutaneous inflammatory dermatoses.

journal_name

Clin Exp Dermatol

authors

Whittaker S

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

81-7

issue

2

eissn

0307-6938

issn

1365-2230

journal_volume

21

pub_type

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