Dermatological manifestations of Down's syndrome.

abstract：BACKGROUND:Psoriasis involves a multifaceted interplay of keratinocytes, blood vessels, immune system mediators and expressed genes. AIM:To determine whether genetic polymorphisms in the angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2) and caspase-5 (CASP5) genes are associated with an increased risk of developing pso...

journal_title：Clinical and experimental dermatology

authors： He L,Dang L,Zhou J,Bai J,Li YZ

更新日期：2015-07-01 00:00:00

abstract：:An earlier standard syphilology textbook states that 'If vesicles are an essential part of an eruption in an adult, the lesions are not due to secondary syphilis'. However, vesicular and bullous eruptions do occur in congenital syphilis and rare reports of both vesicular and pustular eruptions in adults with secondary...

journal_title：Clinical and experimental dermatology

authors： Lawrence P,Saxe N

更新日期：1992-01-01 00:00:00

abstract：:It is only in the past 10 years that the allergenic potential of topical corticosteroids has been fully realized. This has an important impact on the management of patients with chronic eczematous eruptions. Nonhalogenated topical steroids are more frequent sensitizers than halogenated molecules. Tixocortol pivalate a...

journal_title：Clinical and experimental dermatology

authors： English JS

更新日期：2000-06-01 00:00:00

abstract：:Tender nodules may develop at the site of injection of allergen extracts. Some cases can be related to the aluminium contained in the preparation. We report a case where scar sarcoidosis developed at the site of desensitization injections. At presentation, there were no other cutaneous signs of sarcoidosis; systemic s...

journal_title：Clinical and experimental dermatology

authors： Healsmith MF,Hutchinson PE

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive skin disease caused by mutations in the type VII collagen gene (COL7A1), resulting in detachment of the entire epidermis due to loss or hypoplasticity of the anchoring fibrils that normally secure the basement membrane to the underly...

journal_title：Clinical and experimental dermatology

authors： Hanafusa T,Tamai K,Umegaki N,Yamaguchi Y,Fukuda S,Nishikawa Y,Yaegashi N,Okuyama R,McGrath JA,Katayama I

更新日期：2012-01-01 00:00:00

abstract：:Like many other cancers, melanoma has a significant genetic basis. However, its genetic pathways may involve multiple genes with probable interactions with sun exposure. Germline mutations in p16 or CDKN2A are found in a significant percentage of relatively rare melanoma families but p16 mutations are uncommon in spor...

journal_title：Clinical and experimental dermatology

authors： Bataille V

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease caused by genetic and epigenetic factors. There are conflicting results in the literature about the association between psoriasis and the methylenetetrahydrofolate reductase gene (MTHFR), ranging from strong linkage to no association. AIM:To investigat...

journal_title：Clinical and experimental dermatology

authors： Kilic S,Ozdemir O,Silan F,Isik S,Yildiz O,Karaagacli D,Silan C,Ogretmen Z

更新日期：2017-01-01 00:00:00

abstract：:Evidence has suggested that vascular endothelial growth factor (VEGF), a crucial growth factor in regulating endothelial progenitor cells (EPCs), plays a central role in keloid formation. However, the levels of circulating EPCs in patients with keloid have not yet been explored. The aim of this study was to determine ...

journal_title：Clinical and experimental dermatology

authors： Zhang GY,Wu LC,Liao T,Chen G,Chen YH,Meng XC,Wang AY,Chen SY,Lin K,Lin DM,Gao WY,Li QF

更新日期：2016-03-01 00:00:00

abstract：:Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. We report a case in which identical T-cell clones were identified in both patch and tumour stage lesions and in which the tumorous deposits, containing CD30-positive cells, regressed spontaneously. We discuss the differential diagnosis of the tumorou...

journal_title：Clinical and experimental dermatology

authors： Woodrow SL,Basarab T,Russell Jones R

更新日期：1996-09-01 00:00:00

abstract：:Teledermatology has been the focus of much interest in recent years. Potential uses include a simple supporting role for primary care, more accurate triage of dermatology patients or an 'advice only' service reducing the need for dermatology patients to attend outpatient clinics. With the current under-provision of de...

journal_title：Clinical and experimental dermatology

authors： Mallett RB

更新日期：2003-07-01 00:00:00

abstract：:A case of disseminated Kaposi sarcoma in a 76-year-old woman treated with low-dose steroids for a seronegative polyarthritis is described. HIV serology was negative, whereas PCR for HHV-8 was positive. The patient presented with a profound reduction in the peripheral blood CD4+ cell count and a decrease in serum immun...

journal_title：Clinical and experimental dermatology

authors： Fierro MT,Savoia P,Quaglino P,Novero D,Bernengo MG

更新日期：2005-07-01 00:00:00

abstract：:Despite the negative effects of androgenetic alopecia (AGA), no standardized health-related quality of life (HRQOL) questionnaire which is both specific to women and suitable for use in clinical trials currently exists. A questionnaire to assess HRQOL in women with AGA, the Women's Androgenetic Alopecia Quality of Lif...

journal_title：Clinical and experimental dermatology

authors： Dolte KS,Girman CJ,Hartmaier S,Roberts J,Bergfeld W,Waldstreicher J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin carcinoma. AIM:To investigate the function of key micro(mi)RNAs and to explore the potential molecular mechanisms involved in BCC. METHODS:The microarray dataset GSE34535, which comprises seven BCC samples and seven control samples, was downloaded ...

journal_title：Clinical and experimental dermatology

authors： Mi X,Lai K,Yan L,Xie S,Qiu X,Xiao S,Wei S

更新日期：2020-12-01 00:00:00

abstract：:A 78-year-old Caucasian woman developed Sweet's syndrome which progressed over 3 weeks to pyoderma gangrenosum and subcorneal pustule formation. In spite of treatment the patient died and post-mortem examination revealed cryptogenic cirrhosis which could have explained the spectrum of neutrophilic skin disease observe...

journal_title：Clinical and experimental dermatology

authors： Davies MG,Hastings A

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Tinea unguium is a dermatophyte infection of the nails. Itraconazole is a broad-spectrum antifungal drug used to treat this disease. It works by interfering with the synthesis of ergosterol in the cell membrane, thus causing changes that can be seen under scanning electron microscopy (SEM). AIM:To observe u...

journal_title：Clinical and experimental dermatology

authors： Yue X,Wang A,Sun Y,Li Q

更新日期：2018-12-01 00:00:00

abstract：:Topical application of leukotriene-B4 (LTB4) on normal skin has been used as an in-vivo model to investigate cutaneous inflammation and epidermal proliferation, which are important phenomena in the pathogenesis of psoriasis. The aim of the present investigation is to further elucidate the interrelation between inflamm...

journal_title：Clinical and experimental dermatology

authors： de Jong EM,van Erp PE,van Vlijmen IM,van de Kerkhof PC

更新日期：1992-11-01 00:00:00

abstract：:We present a patient with multiple leiomyomas confined to the left cheek, giving rise to an unusual clinical presentation of this condition. The lesions were cosmetically disfiguring and, because of their exposed location, were particularly painful in the winter months. The treatment of this condition is discussed. ...

journal_title：Clinical and experimental dermatology

authors： Tatnall FM,Leigh IM

更新日期：1990-07-01 00:00:00

abstract：:We present a case of paraneoplastic pemphigus associated with Castleman's disease. Our patient had stomatitis and vulvar erosions followed by a cutaneous polymorphous eruption. Investigations for neoplasia disclosed a Castleman's tumour suggesting the diagnosis of paraneoplastic pemphigus. The diagnosis was supported ...

journal_title：Clinical and experimental dermatology

authors： Caneppele S,Picart N,Bayle-Lebey P,Paul J,Irsutti M,Oksman F,Joly P,Bazex J

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Acne vulgaris is a common skin problem that affects up to 90% of adolescents. Colonization of the duct with Propionibacterium species is one of the factors implicated in the development of acne. Owing to the increasing incidence of antibiotic resistance, there has been an greater interest in the development ...

journal_title：Clinical and experimental dermatology

authors： Yung A,Stables GI,Fernandez C,Williams J,Bojar RA,Goulden V

更新日期：2007-11-01 00:00:00

abstract：:We present two patients who developed pseudoporphyria whilst taking isotretinoin (Roaccutane). At that time, both patients were receiving other agents which could be incriminated as causing their pseudoporphyria. However, it is significant that these other agents had been longstanding and that the porphyria-like cutan...

journal_title：Clinical and experimental dermatology

authors： Riordan CA,Anstey A,Wojnarowska F

更新日期：1993-01-01 00:00:00

abstract：:We report a patient with chronic urticaria which was closely associated with elevated levels of thyroxine. The urticaria responded poorly to antihistamines and only partially to systemic steroids, but resolved consistently when the thyroxine level was reduced to normal. The mechanism for the association may involve mo...

journal_title：Clinical and experimental dermatology

authors： Henderson CA,Highet AS

更新日期：1995-03-01 00:00:00

abstract：:Fourteen patients with psoriasis received long-term treatment with cyclosporin (CsA). Among patients there was great variability in the minimal effective CsA dose. In most patients long-term treatment was limited due to dose reductions made necessary because of side-effects. The therapeutic window for CsA seems small....

journal_title：Clinical and experimental dermatology

authors： Korstanje MJ,Van de Staak WJ

更新日期：1991-01-01 00:00:00

abstract：:A 68-year-old woman developed allergic contact dermatitis to topical metronidazole gel as proven by positive patch tests to the gel and to metronidazole. She was also allergic to methylchloroisothiazolinone and methylisothiazolinone (MC/MI). The similarity between the two molecules and the fact that the patient reacte...

journal_title：Clinical and experimental dermatology

authors： Wolf R,Orion E,Matz H

更新日期：2003-09-01 00:00:00

abstract：:Melkersson-Rosenthal syndrome (MRS) is an uncommon, complex neuromucocutaneous disorder characterized by recurrent orofacial oedema, facial palsy and fissured tongue. Complete MRS is uncommon. A case of complete MRS with multiple cranial nerve palsies is reported. ...

journal_title：Clinical and experimental dermatology

authors： Zeng W,Geng S,Niu X,Yuan J

更新日期：2010-04-01 00:00:00

abstract：:Osteoporosis has been observed with chronic hypervitaminosis A, leading some authors to hypothesize that systemic retinoids may have an effect on bone mineral density. Two previous small studies identified osteoporosis in patients who received long-term therapy with etretinate. Etretinate has now been superceeded by a...

journal_title：Clinical and experimental dermatology

authors： McMullen EA,McCarron P,Irvine AD,Dolan OM,Allen GE

更新日期：2003-05-01 00:00:00

abstract：:Desmoplastic trichoepithelioma (DT) is a rare benign adnexal neoplasm considered to have follicular differentiation. It usually presents as an asymptomatic, firm, annular plaque with a raised border. The most common site of occurrence is the face, usually on the cheek. Females are more often affected than males and th...

journal_title：Clinical and experimental dermatology

authors： Carter JJ,Kaur MR,Hargitai B,Brown R,Slator R,Abdullah A

更新日期：2007-09-01 00:00:00

abstract：:Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86-year-old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with...

journal_title：Clinical and experimental dermatology

authors： Choo KJL,Ng SK,Sim CS,Cheng SWN

更新日期：2017-06-01 00:00:00

abstract：:Recent studies have shown that the protein MIA (melanoma inhibitory activity) is a potent serum marker for malignant melanoma. MIA is expressed in chondrocytes at high levels, and might potentially be elevated during periods of growth in childhood. Therefore, we evaluated MIA serum levels in pregnant women and in grow...

journal_title：Clinical and experimental dermatology

authors： Bosserhoff AK,Küster H,Hein R

更新日期：2004-11-01 00:00:00

abstract：:Nail involvement is estimated to affect 80-90% of patients with psoriasis at some point in their lives and is often associated with severe disease. Patients with nail involvement experience pain, functional impairment and social stigma, with significant restriction of daily activities and quality of life. Nail psorias...

journal_title：Clinical and experimental dermatology

authors： Thomas L,Azad J,Takwale A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Therapeutics targeting tumour necrosis factor (TNF)-α are effective for psoriasis; however, in patients treated for other disorders, psoriasis may worsen and psoriasiform dermatitis (PsoD) may arise. T helper (Th) cytokines in psoriasis upregulate keratin (K)17, which modulates TNF-α transduction, leading to...

journal_title：Clinical and experimental dermatology

authors： Moy AP,Murali M,Kroshinsky D,Horn TD,Nazarian RM

更新日期：2018-01-01 00:00:00