Investigation of the mechanism of action of 2% fusidic acid lotion in the treatment of acne vulgaris.

abstract：:Aicardi-Goutières syndrome type 6 (AGS6) and dyschromatosis symmetrica hereditaria (DSH) are allelic disorders caused respectively by biallelic and heterozygous pathogenic variants in ADAR1. We report three unrelated children presenting with features of both AGS6 and DSH, two of whom had compound heterozygous pathogen...

journal_title：Clinical and experimental dermatology

authors： Sathishkumar D,Muthusamy K,Gupta A,Malhotra M,Thomas M,Koshy B,Jasper A,Danda S,George R

更新日期：2020-12-07 00:00:00

abstract：:The use of an aqueous solution of 0.5% topical glycopyrollate was effective in the treatment of hyperhidrosis of the scalp and forehead after other treatments had proved ineffective; this appears to be the first report of its use in this condition. ...

journal_title：Clinical and experimental dermatology

authors： Seukeran DC,Highet AS

更新日期：1998-09-01 00:00:00

abstract：:This randomized double-blind controlled study examined whether sulphydryl-containing agents influence the healing of venous ulceration occurring for the first time on the medial side of the leg. Graduated compression bandaging, which exerted a mean ankle pressure of 40.6 +/- 0.4 mmHg, and a mean below-knee pressure of...

journal_title：Clinical and experimental dermatology

authors： Salim AS

更新日期：1992-11-01 00:00:00

abstract：:Photo-damage of the head and neck was assessed, by visual inspection, in 82 Northern European renal transplant recipients attending a dermatology clinic. Photo-damage was graded as absent, mild, moderate and severe and the presence or absence of skin telangiectasia, solar elastosis, erythema and pigmentation was asses...

journal_title：Clinical and experimental dermatology

authors： Cooper SM,Wojnarowska F

更新日期：2003-11-01 00:00:00

abstract：:Many types of histiocytoses have been described. We present a case of a 56-year-old woman who presented with multiple nodules on the hands. On histological examination of an excision biopsy, a mainly dermal lesion was seen, with scattered mononuclear inflammatory cells and occasional multinucleated cells in the backgr...

journal_title：Clinical and experimental dermatology

authors： Patel AN,Cohen SN,Leach IH,Scharrer K

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:We conducted a re-audit of the surgical practice of UK dermatologists for the treatment of nonmelanoma skin cancer and examined changes with reference to our previous audit in 2014. The audit was supplemented by a detailed assessment of completeness of the histopathology reports for each tumour. METHODS:UK ...

journal_title：Clinical and experimental dermatology

authors： Keith DJ,Bray AP,Brain A,Mohd Mustapa MF,Barrett HE,Lane S,Emmerich M,Jakes A,Barrett PD,de Berker DAR

更新日期：2020-01-01 00:00:00

abstract：:Japan is currently experiencing many outbreaks of scabies, occurring mainly in long-term care facilities. Scabies burrows, the only pathognomonic lesion for scabies, often occur on the creases of the palms, and are followed by a pattern of scale reminiscent of the 'wake' left on the surface of water by a moving bird o...

journal_title：Clinical and experimental dermatology

authors： Yoshizumi J,Harada T

更新日期：2009-08-01 00:00:00

abstract：:We describe a case of a 67-year-old woman with a 1-year history of nail thickening and a non-itchy erythematous scaly eruption on the fingertips. She was diagnosed with psoriasis and started on methotrexate after having had no response to topical calcipotriol. The diagnosis was reviewed after it was revealed by anothe...

journal_title：Clinical and experimental dermatology

authors： Goyal NN,Wong GA

更新日期：2008-03-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma of the skin, usually occurring at sun-exposed sites in elderly people. Divergent differentiation in MCC, although rare, has been reported in previous case series. We describe two new cases of MCC with divergent differentiation. Patient 1 was a 96-y...

journal_title：Clinical and experimental dermatology

authors： Gaitskell K,Nassar S,Ibrahim H

更新日期：2020-04-01 00:00:00

abstract：:Recent studies have shown that the protein MIA (melanoma inhibitory activity) is a potent serum marker for malignant melanoma. MIA is expressed in chondrocytes at high levels, and might potentially be elevated during periods of growth in childhood. Therefore, we evaluated MIA serum levels in pregnant women and in grow...

journal_title：Clinical and experimental dermatology

authors： Bosserhoff AK,Küster H,Hein R

更新日期：2004-11-01 00:00:00

abstract：:A case of pure non-epidermotropic cutaneous lymphoma in a human immunodeficiency virus-infected patient is reported following a viral opportunistic infection [cytomegalovirus (CMV) hepatitis]. The lymphoid infiltrate was Epstein-Barr virus and CMV negative with a CD30-positive T-cell phenotype. Molecular analysis demo...

journal_title：Clinical and experimental dermatology

authors： Viraben R,Brousset P,Aquilina C,Lamant L

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Infantile haemangiomas (IHs) are the most common vascular tumours of infancy. Topical therapies are a possible treatment for superficial IHs. AIM:To determine the efficacy and safety of topical therapy in the treatment of superficial proliferating IHs. METHODS:The medical records of all the patients with p...

journal_title：Clinical and experimental dermatology

authors： Qiu Y,Ma G,Yang J,Hu X,Chen H,Jin Y,Lin X

更新日期：2013-12-01 00:00:00

abstract：:Endogenous ochronosis or alkaptonuria is a rare, autosomal recessive disease of tyrosine metabolism that is caused by a deficiency of the enzyme homogentisic acid oxidase. The disease results in the accumulation and deposition of homogentisic acid in the cartilage, eyelids, forehead, cheeks, axillae, genital region, b...

journal_title：Clinical and experimental dermatology

authors： Turgay E,Canat D,Gurel MS,Yuksel T,Baran MF,Demirkesen C

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Therapeutics targeting tumour necrosis factor (TNF)-α are effective for psoriasis; however, in patients treated for other disorders, psoriasis may worsen and psoriasiform dermatitis (PsoD) may arise. T helper (Th) cytokines in psoriasis upregulate keratin (K)17, which modulates TNF-α transduction, leading to...

journal_title：Clinical and experimental dermatology

authors： Moy AP,Murali M,Kroshinsky D,Horn TD,Nazarian RM

更新日期：2018-01-01 00:00:00

abstract：:Ras-associated autoimmune leucoproliferative disorder (RALD) is a nonmalignant syndrome associated with somatic KRAS mutations. We report a patient with RALD and cutaneous lesions, the first such case reported, to our knowledge. An 8-year-old boy presented with erythematous plaques on his face and body, along with lym...

journal_title：Clinical and experimental dermatology

authors： Giacaman A,Bauzá Alonso A,Salinas Sanz JA,Dapena Díaz JL,Ramos Asensio R,Ferrés Ramis L,Durán Pastor MA,Martín-Santiago A

更新日期：2018-12-01 00:00:00

abstract：:A 34-year-old woman presented with 2-year history of a dome-shaped papule on a well-circumscribed, thickened, port-wine stain on the left side of the chin. Squeezing on the port-wine-stain plaque revealed many comedos within dilated follicular orifices. The papule was excised and submitted for histological examination...

journal_title：Clinical and experimental dermatology

authors： Yang CH,Shen SC,Yeh JT,Tsai YL,Hong HS

更新日期：2005-09-01 00:00:00

abstract：:Pruritic folliculitis (PF) is one of the specific dermatoses of pregnancy the aetiology of which remains unknown. Several theories have been proposed, and the most commonly accepted is that it represents a hormonally induced acne, as seen in patients taking progestogenic steroids. This theory led to the proposition th...

journal_title：Clinical and experimental dermatology

authors： Vaughan Jones SA,Hern S,Black MM

更新日期：1999-09-01 00:00:00

abstract：:An unusual giant combined dermatofibroma is reported in a 34-year-old man who presented with skin-coloured swellings on the medial aspect of the left scapula. The plaque was well defined, reddish-brown and 25-30 cm in diameter. It was also tender and indurated. Several similar smaller lesions (satellites) were present...

journal_title：Clinical and experimental dermatology

authors： Sehgal VN,Sardana K,Khandpur S,Sharma S,Majumdar S,Aggarwal AK

更新日期：2004-03-01 00:00:00

abstract：:Controlled trials and clinical experience indicate that systemic cyclosporin A and tacrolimus are effective treatments for psoriasis, and that cyclosporin A also improves atopic eczema. A variety of other inflammatory and non-inflammatory skin diseases are probably also responsive to these drugs. However, the widespre...

journal_title：Clinical and experimental dermatology

authors： Reynolds NJ,Al-Daraji WI

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The motivations for patients presenting to melanoma screening clinics (MSCs) with concerning skin lesions are poorly understood. Social media (SoMe) refers to online platforms designed to facilitate sharing of information with billions of users worldwide. There is evidence of patients posting skin lesion 'se...

journal_title：Clinical and experimental dermatology

authors： Guckian J,Jobling K,Oliphant T,Weatherhead S,Blasdale K

更新日期：2020-04-01 00:00:00

abstract：:Urticarial vasculitis (UV) is a mainly leucocytoclastic vasculitis with urticarial plaques. Treating these patients is challenging as the available treatments have poor efficacy. Oral corticosteroids are considered the first-line treatment, but H1 antihistamines, dapsone, colchicine, antimalarials, ciclosporin and ant...

journal_title：Clinical and experimental dermatology

authors： Fueyo-Casado A,Campos-Muñoz L,González-Guerra E,Pedraz-Muñoz J,Cortés-Toro JA,López-Bran E

更新日期：2017-06-01 00:00:00

abstract：:Complete deficiency of the fourth component of complement (C4) is an extremely rare condition. However, it has been reported that partial C4 deficiency can occur in normal subjects, and is associated with several immune diseases. We report a 44-year-old woman who developed slight oedema and punctate purpura on her low...

journal_title：Clinical and experimental dermatology

authors： Kosaka S,Osada S,Kaneko T,Nishimura S,Kawana S

更新日期：2013-07-01 00:00:00

abstract：:The effect of Anandron, a novel non-steroidal anti-androgen, on the reduction in sexual hair growth of 14 male-to-female transsexuals was investigated. Anandron (300 mg/day) alone for 8 weeks increased serum testosterone levels (mean: 19.2 +/- 6.1 to 44.9 +/- 11.5 mmol/l) and serum oestradiol levels (mean: 0.08 +/- 0....

journal_title：Clinical and experimental dermatology

authors： Asscheman H,Gooren LJ,Peereboom-Wynia JD

更新日期：1989-09-01 00:00:00

abstract：:Porphyria cutanea tarda (PCT) is believed to be associated with reduced hepatic uroporphyrinogen decarboxylase activity and risk factors such as alcohol abuse and medication with oral contraceptives and certain other drugs. Recently it has been suggested that hepatitis C virus (HCV) infection may also be associated wi...

journal_title：Clinical and experimental dermatology

authors： Hussain I,Hepburn NC,Jones A,O'Rourke K,Hayes PC

更新日期：1996-07-01 00:00:00

abstract：:This article forms part of a series of annual updates that summarizes the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed during 2017, and focuses on the epidemiology, aetiology and risk factors of AE. AE is the largest single contri...

journal_title：Clinical and experimental dermatology

authors： Hale G,Davies E,Grindlay DJC,Rogers NK,Harman KE

更新日期：2019-12-01 00:00:00

abstract：:A 68-year-old woman developed allergic contact dermatitis to topical metronidazole gel as proven by positive patch tests to the gel and to metronidazole. She was also allergic to methylchloroisothiazolinone and methylisothiazolinone (MC/MI). The similarity between the two molecules and the fact that the patient reacte...

journal_title：Clinical and experimental dermatology

authors： Wolf R,Orion E,Matz H

更新日期：2003-09-01 00:00:00

abstract：:A 19-year-old-male, previously diagnosed case of tuberous sclerosis complex, presented to us with gradually progressive thickening of the fourth finger of his right hand that was first noticed at seven years of age. There was no pain or difficulty in moving the finger. On examination, the distal aspect of the fourth d...

journal_title：Clinical and experimental dermatology

authors： Sindhuja T,Agarwal S,Gupta V

更新日期：2021-01-28 00:00:00

abstract：:Treatment of autoimmune blistering diseases consists of systemic glucocorticosteroids usually in combination with additional immunosuppressants such as azathioprine and mycophenolate mofetil or immunomodulators such as dapsone, antibiotics, intravenous immunoglobulins, and immunoadsorption. In some patients, these tre...

journal_title：Clinical and experimental dermatology

authors： Schmidt E,Hunzelmann N,Zillikens D,Bröcker EB,Goebeler M

更新日期：2006-07-01 00:00:00

abstract：:Determining the risk of progression to systemic lupus erythematosus (SLE) among patients diagnosed with discoid lupus erythematosus (DLE), and the time frame of this risk, are important clinical questions. Past reports have demonstrated a wide time frame of progression from DLE to SLE, with mean time to progression of...

journal_title：Clinical and experimental dermatology

authors： Elman SA,Joyce C,Costenbader KH,Merola JF

更新日期：2020-01-01 00:00:00

abstract：:The high-affinity receptor for immunoglobulin E (IgE), FcepsilonRI, plays a central role in the initiation and control of atopic allergic inflammation. On mast cells and basophils, the function of the receptor is well known and constitutes cellular degranulation and the release of various mediators. FcepsilonRI on ant...

journal_title：Clinical and experimental dermatology

authors： von Bubnoff D,Novak N,Kraft S,Bieber T

更新日期：2003-03-01 00:00:00