Abstract:
:We report a 73-year-old man who developed repeated episodes of erythematous, bullous plaques beginning 3 months after discontinuation of combination treatment with pegylated interferon (IFN)-alpha-2b and ribavirin for hepatitis C virus infection. The first episode resolved within a week without treatment, but the lesions recurred about once a month and were associated with high fever. Physical examination found darkly reddish, pigeon-egg-sized erythematous plaques with occasional flaccid blisters, predominantly on the trunk and proximal limbs, lip and penis. Histological examination showed well-demarcated foci of full-thickness epidermal necrosis and exocytosis of lymphoid cells. Pegylated IFN-alpha2b and ribavirin produced no response in lymphocyte stimulation tests. Systemic prednisolone led to rapid healing of skin lesions at the time of the fifth episode, leaving pigmented macules, but lesions recurred at the same sites within weeks of discontinuation of this treatment. It is uncertain whether this case represented a prolonged drug rash provoked by pegylated IFN-alpha2b or a fixed eruption in response to another antigen.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Sato M,Sueki H,Iijima Mdoi
10.1111/j.1365-2230.2009.03560.xsubject
Has Abstractpub_date
2009-12-01 00:00:00pages
e814-7issue
8eissn
0307-6938issn
1365-2230pii
CED3560journal_volume
34pub_type
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journal_title:Clinical and experimental dermatology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical and experimental dermatology
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pub_type: 临床试验,杂志文章,随机对照试验
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