Clinical response to antibiotic regimens in lower limb cellulitis: a systematic review.


:There is variation in the treatment of lower limb cellulitis (LLC) with no agreement on the most effective antibiotic regimen. Many patients with cellulitis fail to respond to first-line antibiotics. This can negatively affect patient care and result in unnecessary hospital admissions. The aim of this systematic review was to determine the clinical response and safety of antibiotic regimens for the management of LLC. A systematic review for randomized controlled trials (RCTs) was conducted using OVID MEDLINE, Ovid Embase and Cochrane Central Register of Controlled Trials in January 2019. Outcomes of interest included the clinical response to antibiotic regimens (type, dose, route, duration) and the safety of antibiotics in LLC. Trial quality was identified using the Cochrane Risk of Bias tool. Four RCTs were included. All included studies showed no significant differences between the clinical response to different antibiotic type, administration route, treatment duration or dose. LLC may be overtreated and shorter courses of oral antibiotics, possibly with lower doses, may be more suitable. There is a lack of published data on the clinical response and safety of antibiotics in LLC. Three studies were high risk for bias overall. Further high-quality studies may help determine whether less intensive antibiotic regimens can effectively treat LLC.


Clin Exp Dermatol


Mistry K,Sharma S,Patel M,Grindlay D,Janjuha R,Smart P,Levell NJ




Has Abstract


2021-01-01 00:00:00












  • Induction of hair growth in alopecia totalis with diphencyprone sensitization.

    abstract::The therapeutic use of the induction of an allergic contact sensitivity to diphencyprone in alopecia areata has been studied. Fourteen subjects had alopecia totalis and four had extensive and long-standing alopecia areata. Topical diphencyprone was capable of inducing an allergic contact sensitivity in 16 subjects (89...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Monk B

    更新日期:1989-03-01 00:00:00

  • Amelanotic malignant melanoma following cryosurgery for atypical lentigo maligna.

    abstract::Cryosurgery is an alternative treatment option to surgical excision for lentigo maligna. Clinical evidence of recurrence is usually characterized by repigmentation at the treated site. We report two patients who developed amelanotic malignant melanoma following cryosurgery for a pigmented lentigo maligna. These cases ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: McKenna DB,Cooper EJ,Kavanagh GM,Davie RM,McLaren KM,Tidman MJ

    更新日期:2000-11-01 00:00:00

  • Cutaneous lesions in a case of acute megakaryoblastic leukaemia.

    abstract::We describe the case of a 68-year-old woman who presented with asymptomatic skin nodules and symptoms of anaemia, and was found to have acute megakaryoblastic leukaemia with fibrosis, a condition now believed to correspond to the former diagnosis of acute myelofibrosis. There is only one previous report of skin lesion...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Macfarlane AW,Parry DH,Caslin AW,Hughes M

    更新日期:1996-05-01 00:00:00

  • Sex-related differences of clinical features in hidradenitis suppurativa: analysis of an Italian-based cohort.

    abstract::The clinical characteristics associated with hidradenitis suppurativa (HS) severity are poorly understood. In this study, 124 patients with HS from 6 Italian dermatology centres participated in this study. Disease severity was assessed using the Hidradenitis Suppurativa Physician's Global Assessment score (HS-PGA) and...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Bianchi L,Caposiena Caro RD,Ganzetti G,Molinelli E,Dini V,Oranges T,Romanelli M,Fabbrocini G,Monfrecola G,Napolitano M,Egan CG,Musumeci ML,Lacarrubba F,Micali G,Passoni E,Calzavara-Pinton PG,Venturini M,Zanca A,Offida

    更新日期:2019-07-01 00:00:00

  • Asymmetrical periflexural exanthem exhibiting pseudoisomorphic Köebner response in an adult.

    abstract::Asymmetrical periflexural exanthem is a rare clinical condition, seen almost exclusively in children. Very few adult cases have been reported in the literature. We report a case of this rare eruption in an adult man showing characteristic clinical and histological features. Interestingly, this patient also exhibited a...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Dar NR,Raza N

    更新日期:2009-10-01 00:00:00

  • Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study.

    abstract::Determining the risk of progression to systemic lupus erythematosus (SLE) among patients diagnosed with discoid lupus erythematosus (DLE), and the time frame of this risk, are important clinical questions. Past reports have demonstrated a wide time frame of progression from DLE to SLE, with mean time to progression of...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Elman SA,Joyce C,Costenbader KH,Merola JF

    更新日期:2020-01-01 00:00:00

  • Efficacy of topical corticosteroids in nickel-induced contact allergy.

    abstract::In this study we used the nickel contact allergy patch (CAP) test to investigate the effect of topical corticosteroids on allergic contact dermatitis (ACD). On day 1, three CAP tests were applied for 48 h on the forearms of 20 female volunteers with a known nickel ACD. CAP of the right forearm contained 5% nickel, and...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hachem JP,De Paepe K,Vanpée E,Bogaerts M,Kaufman L,Rogiers V,Roseeuw D

    更新日期:2002-01-01 00:00:00

  • HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China.

    abstract::Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR-sequence-specific primers to genotype polymorphisms in HLA-DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Gao XH,Winsey S,Li G,Barnardo M,Zhu XJ,Chen HD,Song F,Zhai N,Fuggle S,Wojnarowska F

    更新日期:2002-06-01 00:00:00

  • Recessive dystrophic epidermolysis bullosa caused by a de novo interstitial deletion spanning COL7A1 and a hemizygous splicing mutation in trans.

    abstract:BACKGROUND:Recessive dystrophic epidermolysis bullosa (RDEB) is a rare heritable blistering skin condition caused by loss-of-function mutations in the COL7A1 gene. Incongruent gene transmission is occasionally reported in recessive diseases, and its underlying mechanism is often uniparental disomy (UPD). AIM:To unders...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Lee M,Xu G,Wang K,Wang H,Zhang J,Tang Z,Lin Z,Yang Y

    更新日期:2016-06-01 00:00:00

  • T-cell receptor gene analysis in cutaneous T-cell lymphomas.

    abstract::An essential property of the immune system is its ability to generate diverse antibody and T-cell mediated responses to virtually any potential foreign particle. The basic molecular mechanisms responsible for producing this extensive diversity have now been elucidated. Each T cell expresses a unique membrane bound T-c...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Whittaker S

    更新日期:1996-03-01 00:00:00

  • Naevoid hypertrichosis--report of a patient with multiple lesions.

    abstract::Naevoid hypertrichosis is an unusual congenital disorder consisting of a solitary circumscribed area of terminal hair growth which is not associated with any other systemic abnormalities. We describe a patient with multiple areas of circumscribed naevoid hypertrichosis on the trunk and limbs who also had lipodystrophy...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Cox NH,McClure JP,Hardie RA

    更新日期:1989-01-01 00:00:00

  • Dermatological manifestations of Down's syndrome.

    abstract::Down's syndrome (DS) is associated with rare dermatological disorders and increased frequency of some common dermatoses. Owing to advances in medical care and changes in attitude, the median age of death in this population has increased to 49 years, and the life expectancy of a 1-year-old person with DS today is more ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Madan V,Williams J,Lear JT

    更新日期:2006-09-01 00:00:00

  • Immunohistochemistry of ultrastructural changes in scarring lupus erythematosus.

    abstract:BACKGROUND:The various clinical types of lupus erythematosus (LE) show an essentially similar histological picture, and the subsets of LE cannot easily be distinguished by histology alone. However, there is an important clinical difference: lesions of discoid LE (DLE) cause scarring, particularly on the scalp, whereas ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Al-Refu K,Goodfield M

    更新日期:2011-01-01 00:00:00

  • Teledermatology in practice.

    abstract::Teledermatology has been the focus of much interest in recent years. Potential uses include a simple supporting role for primary care, more accurate triage of dermatology patients or an 'advice only' service reducing the need for dermatology patients to attend outpatient clinics. With the current under-provision of de...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Mallett RB

    更新日期:2003-07-01 00:00:00

  • De novo missense mutation, S541Y, in the p63 gene underlying Rapp-Hodgkin ectodermal dysplasia syndrome.

    abstract::Rapp-Hodgkin syndrome (RHS) is an autosomal dominant disorder characterized by ectodermal dysplasia and cleft lip/cleft palate. Very recently, mutations in p63 have been identified as a cause of RHS; to date five such mutations have been identified. We describe a Thai girl with RHS. She had short stature, ectodermal d...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Shotelersuk V,Janklat S,Siriwan P,Tongkobpetch S

    更新日期:2005-05-01 00:00:00

  • A 20-year epidemiological study of cutaneous melanoma in the Rijeka district of Croatia.

    abstract::A retrospective study was made of the incidence of cutaneous melanoma among the population of the district of Rijeka (Croatia) during the period 1977-96. A total of 397 patients with cutaneous melanoma was documented during this period. Over the 20-year period the incidence of the tumour increased, the mean annual rat...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Zamolo G,Gruber F,Jonjić A,Cabrijan L,Palle M,Grubisić-Greblo H

    更新日期:2000-01-01 00:00:00

  • Aleukaemic leukaemia cutis presenting as a benign-appearing eruption.

    abstract::A 68-year-old Caucasian male presented with a 5-week history of a widespread pruritic papular eruption. Histology from a papule on the left shoulder showed a dense dermal infiltrate of large mononuclear cells which were positive for leucocyte common antigen, KP1 and PGM1, with an MIB-1 proliferating fraction of 40%, d...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Millard TP,Aitchison R,Wilkinson JD

    更新日期:2003-03-01 00:00:00

  • Loceryl nail lacquer--realization of a new galenical approach to onychomycosis therapy.

    abstract::Loceryl nail lacquer was developed to provide the effective antifungal drug, amorolfine, in a once-weekly dosage regimen combined with a convenient mode of application. Traditional formulations such as creams and nail solutions do not fulfil these requirements because they are wiped or washed off very rapidly. Amorolf...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Pittrof F,Gerhards J,Erni W,Klecak G

    更新日期:1992-09-01 00:00:00

  • Erysipelas complicating chronic discoid lupus erythematosus of the face--a case report and review of erysipelas.

    abstract::We present a case of erysipelas which complicated chronic discoid lupus erythematosus (CDLE) of the face. The diagnosis and implications for management are discussed. The changing epidemiology and clinical spectrum of erysipelas are reviewed. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Keefe M,Wakeel RA,Kerr RE

    更新日期:1989-01-01 00:00:00

  • Multiple dermatofibromata developing during pregnancy.

    abstract::Dermatofibromata are common benign dermal tumours of unknown aetiology. They usually present as a single lesion on the limbs of young adults. Multiple dermatofibromata have been reported occurring in patients with autoimmune disease, who were receiving immunosuppressive treatment. A 25-year-old female is reported who ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Stainforth J,Goodfield MJ

    更新日期:1994-01-01 00:00:00

  • Macrodactyly in tuberous sclerosis complex.

    abstract::A 19-year-old-male, previously diagnosed case of tuberous sclerosis complex, presented to us with gradually progressive thickening of the fourth finger of his right hand that was first noticed at seven years of age. There was no pain or difficulty in moving the finger. On examination, the distal aspect of the fourth d...

    journal_title:Clinical and experimental dermatology

    pub_type: 信件


    authors: Sindhuja T,Agarwal S,Gupta V

    更新日期:2021-01-28 00:00:00

  • Acral histiocytic nodules: a possible new variant of non-X histiocytosis.

    abstract::Many types of histiocytoses have been described. We present a case of a 56-year-old woman who presented with multiple nodules on the hands. On histological examination of an excision biopsy, a mainly dermal lesion was seen, with scattered mononuclear inflammatory cells and occasional multinucleated cells in the backgr...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Patel AN,Cohen SN,Leach IH,Scharrer K

    更新日期:2012-04-01 00:00:00

  • Use of a novel autologous cell-harvesting device to promote epithelialization and enhance appropriate pigmentation in scar reconstruction.

    abstract:BACKGROUND:Epidermal replacement is an important step in the management of patients with post-traumatic and iatrogenic scars. Skin-colour variation from disease or trauma causes significant changes in self-image and appearance. AIM:The aim of our study was to analyse the results obtained with a novel autologous cell-h...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Cervelli V,De Angelis B,Spallone D,Lucarini L,Arpino A,Balzani A

    更新日期:2010-10-01 00:00:00

  • A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing.

    abstract::The clinical and histological effects of retinyl propionate cream (a retinyl ester) on extrinsic skin ageing (photo-ageing) in man were assessed in a double-blind randomized placebo-controlled study of 80 subjects, individual parameters of this being assessed for each treatment site (face, dorsal right forearm and han...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Green C,Orchard G,Cerio R,Hawk JL

    更新日期:1998-07-01 00:00:00

  • Role of autologous mesenchymal stem cells associated with platelet-rich plasma on healing of cutaneous wounds in diabetic mice.

    abstract:BACKGROUND:Chronic cutaneous lesions affect 15% of human patients with diabetes, and the associated risk of limb amputations is 15-46 times greater than that of people with normal glycaemia. It is estimated that half of these limb amputations could be avoided by opportune treatment with somatic stem cells or platelet-r...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Argôlo Neto NM,Del Carlo RJ,Monteiro BS,Nardi NB,Chagastelles PC,de Brito AF,Reis AM

    更新日期:2012-07-01 00:00:00

  • Conjunctival impression cytology, ocular surface and tear-film changes in patients with lichen planus.

    abstract:BACKGROUND:Lichen planus (LP) is an immune-mediated chronic mucocutaneous disease. Rarely, LP affects the conjunctiva, resulting in conjunctival inflammation, cicatrization and scarring of the subepithelium and cornea, causing keratitis and keratoconjunctivitis sicca. To date, there has been no case-control study exami...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Şanli B,Çetin EN,Bir F,Taşli L,Yaldizkaya F,Yaylali V

    更新日期:2012-06-01 00:00:00

  • Facial leiomyomas.

    abstract::We present a patient with multiple leiomyomas confined to the left cheek, giving rise to an unusual clinical presentation of this condition. The lesions were cosmetically disfiguring and, because of their exposed location, were particularly painful in the winter months. The treatment of this condition is discussed. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Tatnall FM,Leigh IM

    更新日期:1990-07-01 00:00:00

  • Association of the interleukin-10 distal promoter (-2763A/C) polymorphism with late-onset psoriasis.

    abstract::Polymorphisms of the IL-10 promoter have been implicated in the genetic susceptibility to many autoimmune diseases, including psoriasis. Four putative functional single-nucleotide polymorphisms (SNPs) within the interleukin-10 promoter region (-3575T/A, -2763A/C, -1082G/A and -592C/A) were analysed in 139 patients wit...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Wongpiyabovorn J,Hirankarn N,Ruchusatsawat K,Yooyongsatit S,Asawanonda P,Poovorawan Y

    更新日期:2008-03-01 00:00:00

  • Pseudoacromegalic facial features in Fabry disease.

    abstract::Although Fabry disease (FD) is an X-linked lysosomal storage disorder, there is a high prevalence of affected heterozygous females who show symptoms and have an increased mortality associated with the disease. FD usually progresses slowly, and death can result from stroke, heart disease or renal failure. Diagnosis can...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Hogarth V,Hughes D,Orteu CH

    更新日期:2013-03-01 00:00:00

  • Elevated MIA levels in the serum of pregnant women and of children.

    abstract::Recent studies have shown that the protein MIA (melanoma inhibitory activity) is a potent serum marker for malignant melanoma. MIA is expressed in chondrocytes at high levels, and might potentially be elevated during periods of growth in childhood. Therefore, we evaluated MIA serum levels in pregnant women and in grow...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Bosserhoff AK,Küster H,Hein R

    更新日期:2004-11-01 00:00:00