New intragenic and promoter region deletion mutations in FERMT1 underscore genetic homogeneity in Kindler syndrome.

abstract：BACKGROUND:Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive skin disease caused by mutations in the type VII collagen gene (COL7A1), resulting in detachment of the entire epidermis due to loss or hypoplasticity of the anchoring fibrils that normally secure the basement membrane to the underly...

journal_title：Clinical and experimental dermatology

authors： Hanafusa T,Tamai K,Umegaki N,Yamaguchi Y,Fukuda S,Nishikawa Y,Yaegashi N,Okuyama R,McGrath JA,Katayama I

更新日期：2012-01-01 00:00:00

abstract：:Evidence has suggested that vascular endothelial growth factor (VEGF), a crucial growth factor in regulating endothelial progenitor cells (EPCs), plays a central role in keloid formation. However, the levels of circulating EPCs in patients with keloid have not yet been explored. The aim of this study was to determine ...

journal_title：Clinical and experimental dermatology

authors： Zhang GY,Wu LC,Liao T,Chen G,Chen YH,Meng XC,Wang AY,Chen SY,Lin K,Lin DM,Gao WY,Li QF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Vulval allergic contact dermatitis (ACD) may be a primary disorder or may be associated with an underlying vulval dermatosis. Few studies have looked at the incidence of ACD and the allergens responsible for it. AIMS:We report the incidence of vulval ACD and the responsible allergens in 282 patients investi...

journal_title：Clinical and experimental dermatology

authors： Al-Niaimi F,Felton S,Williams J

更新日期：2014-06-01 00:00:00

abstract：:Pachydermodactyly describes a rare condition of localized fibromatosis, usually symmetrically affecting the interphalangeal joints of both hands. We describe a case of a new subtype of pachydermodactyly in a 14-year-old boy, which we term 'unilateral pachydermodactyly transgrediens'. This atypical pattern is caused by...

journal_title：Clinical and experimental dermatology

authors： Nicolay JP,Faulhaber J,Kutzner H,Schneider SW

更新日期：2015-08-01 00:00:00

abstract：:Vitiligo usually begins in childhood with approximately half of the patients manifesting onset of disease prior to the age of 20 years. Treatment options in this age group are few and have disappointing response rates. This study was designed to evaluate the role of narrow-band UVB in the treatment of generalized viti...

journal_title：Clinical and experimental dermatology

authors： Kanwar AJ,Dogra S

更新日期：2005-07-01 00:00:00

abstract：:We report the case of a 46-year-old Indian woman who developed a hyperimmune response to a typhoid booster injection in association with the development of pemphigus vulgaris. To our knowledge, this association has not previously been reported. ...

journal_title：Clinical and experimental dermatology

authors： Bellaney GJ,Rycroft RJ

更新日期：1996-11-01 00:00:00

abstract：:Porphyria cutanea tarda (PCT) is believed to be associated with reduced hepatic uroporphyrinogen decarboxylase activity and risk factors such as alcohol abuse and medication with oral contraceptives and certain other drugs. Recently it has been suggested that hepatitis C virus (HCV) infection may also be associated wi...

journal_title：Clinical and experimental dermatology

authors： Hussain I,Hepburn NC,Jones A,O'Rourke K,Hayes PC

更新日期：1996-07-01 00:00:00

abstract：:A scleroderma-like disease has recently been described in association with taxanes. We present the first case of diffuse scleroderma occurring in a woman treated with doxorubicin and cyclophosphamide for breast cancer. The clinical pattern of skin involvement and histological alterations were identical to those found ...

journal_title：Clinical and experimental dermatology

authors： Alexandrescu DT,Bhagwati NS,Wiernik PH

更新日期：2005-03-01 00:00:00

abstract：:A 45-year-old man presented with a 7-year history of keratosis lichenoides chronica (KLC), a mucocutaneous lichenoid disorder of keratinization with no known aetiology, without significant systemic associations. Our patient also had type I diabetes mellitus, mild hypertension and lipid abnormalities. The diagnosis and...

journal_title：Clinical and experimental dermatology

authors： Wozniacka A,Schwartz RA,Omulecki A,Lesiak A,Sysa-Jedrzejowska A

更新日期：2006-01-01 00:00:00

abstract：:Four patients presenting with chronic pigmented purpuric dermatosis (CPPD) on the limbs were found to have granulomatous inflammation superimposed on the pathological changes of CPPD. Three of the four patients had hyperlipidaemia. Therefore, the granulomatous reaction observed could be associated with hyperlipidaemia...

journal_title：Clinical and experimental dermatology

authors： Lin WL,Kuo TT,Shih PY,Lin WC,Wong WR,Hong HS

更新日期：2007-09-01 00:00:00

abstract：:Genetic factors predisposing individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. Patients with BD exhibit elevated levels of pro-inflammatory cytokines, and affected organs show a significant neutrophil and lymphocyte infiltration. Current evidence suggests th...

journal_title：Clinical and experimental dermatology

authors： Sallakci N,Bacanli A,Coskun M,Yavuzer U,Alpsoy E,Yegin O

更新日期：2005-09-01 00:00:00

abstract：:We report the cases of two patients who developed generalized pustular psoriasis on the withdrawal of oral Cyclosporin treatment for persistent palmoplantar pustulosis. This complication does not appear to have been reported previously. ...

journal_title：Clinical and experimental dermatology

authors： De Silva BD,Benton EC,Tidman MJ

更新日期：1999-01-01 00:00:00

abstract：:We describe the case of a 68-year-old woman who presented with asymptomatic skin nodules and symptoms of anaemia, and was found to have acute megakaryoblastic leukaemia with fibrosis, a condition now believed to correspond to the former diagnosis of acute myelofibrosis. There is only one previous report of skin lesion...

journal_title：Clinical and experimental dermatology

authors： Macfarlane AW,Parry DH,Caslin AW,Hughes M

更新日期：1996-05-01 00:00:00

abstract：:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an...

journal_title：Clinical and experimental dermatology

authors： Quartey QQ,Miller RJ,Pinsker BL,Okoh UJ,Shipman WD,George BA,Nwizu CC,Barnes LA,Kerns ML,Caffrey JA,Aliu O,Brown ID,Succaria F,Maynard JP,Herbert AS,Kang S,Miller LS,Okoye GA,Byrd AS

更新日期：2020-03-01 00:00:00

abstract：:We describe an 18-year-old girl with systemic lupus erythematosus (SLE) who had cutaneous papulonodular mucinosis (PNM) as the first sign of SLE. She presented with multiple flesh-coloured papules on the face, abdomen and limbs. Histological examination of a biopsy taken from a papule showed diffuse deposition of muci...

journal_title：Clinical and experimental dermatology

authors： Shekari AM,Ghiasi M,Ghasemi E,Kani ZA

更新日期：2009-12-01 00:00:00

abstract：:A 78-year-old Caucasian woman developed Sweet's syndrome which progressed over 3 weeks to pyoderma gangrenosum and subcorneal pustule formation. In spite of treatment the patient died and post-mortem examination revealed cryptogenic cirrhosis which could have explained the spectrum of neutrophilic skin disease observe...

journal_title：Clinical and experimental dermatology

authors： Davies MG,Hastings A

更新日期：1991-07-01 00:00:00

abstract：:A 55-year-old diabetic female treated with a combination of a short- and intermediate-acting insulin, developed sterile furunculoid lesions at the injection sites which eventually healed with atrophic scars. Histopathologically, an initial neutrophilic stage was followed by granulomatous and fibrotic stages. It was co...

journal_title：Clinical and experimental dermatology

authors： Jordaan HF,Sandler M

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin carcinoma. AIM:To investigate the function of key micro(mi)RNAs and to explore the potential molecular mechanisms involved in BCC. METHODS:The microarray dataset GSE34535, which comprises seven BCC samples and seven control samples, was downloaded ...

journal_title：Clinical and experimental dermatology

authors： Mi X,Lai K,Yan L,Xie S,Qiu X,Xiao S,Wei S

更新日期：2020-12-01 00:00:00

abstract：:This paper reports a unique case of coexistence of vitiligo vulgaris, lichen planus and psoriasis vulgaris in a 53-year-old man. Five years after the onset of vitiligo, lichen planus developed on his lower lip. Another 4 years after the onset of lichen planus, he also exhibited psoriasis on his upper arms and trunk. B...

journal_title：Clinical and experimental dermatology

authors： Ujiie H,Sawamura D,Shimizu H

更新日期：2006-05-01 00:00:00

abstract：:Systemic sclerosis (SSc) is often complicated by severe skin ulcers that are unresponsive to traditional treatments. Vascular alterations are responsible for the ischaemic features of the disease in both the skin and visceral organs. Defective neoangiogenesis correlates with an abnormally reduced quantity of circulati...

journal_title：Clinical and experimental dermatology

authors： Ferri C,Giuggioli D,Manfredi A,Quirici N,Scavullo C,Colaci M,Gianelli U,Deliliers GL,Del Papa N

更新日期：2010-12-01 00:00:00

abstract：:Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction, which is mostly due to drugs, but which has also been described as occurring after infections. We report a case of severe AGEP with extensive blistering mimicking toxic epidermal necrolysis (TEN) in a 47-year-old woman. This was ...

journal_title：Clinical and experimental dermatology

authors： Azib S,Florin V,Fourrier F,Delaporte E,Staumont-Sallé D

更新日期：2014-08-01 00:00:00

abstract：:Human papilloma virus is a common and often distressing cutaneous disease. It can be therapeutically challenging, especially in immunocompromised patients. We report a case of recalcitrant cutaneous warts that resolved with intravenous cidofovir treatment. The patient was immunocompromised secondary to monoclonal anti...

journal_title：Clinical and experimental dermatology

authors： McAleer MA,Bourke J

更新日期：2011-08-01 00:00:00

abstract：:We describe a patient with intermittent unilateral hyperhidrosis localized to the left hand only. Histology confirmed the presence of an eccrine naevus. ...

journal_title：Clinical and experimental dermatology

authors： Parslew R,Lewis-Jones MS

更新日期：1997-09-01 00:00:00

abstract：:Guadeloupe is a French Caribbean island, with a population of mainly African ancestry, and a high standard of living. We recorded the dermatological diagnoses in 5000 new patients attending dermatologists. The main diagnoses were acne (16.4%), superficial mycoses (12.8%), and eczema (10.5%). Diseases considered to be ...

journal_title：Clinical and experimental dermatology

authors： Mahé A,Mancel E

更新日期：1999-09-01 00:00:00

abstract：:A female patient is presented who consistently developed lesions of disseminated superficial porokeratosis (DSP) whilst on holiday abroad. The lesions resolved completely within 4-6 weeks of return to the UK. Induction of the lesions by exposure to artificial sources of UVA and UVB was unsuccessful. Disseminated super...

journal_title：Clinical and experimental dermatology

authors： Ibbotson SH

更新日期：1996-01-01 00:00:00

abstract：:We report a patient with chronic urticaria which was closely associated with elevated levels of thyroxine. The urticaria responded poorly to antihistamines and only partially to systemic steroids, but resolved consistently when the thyroxine level was reduced to normal. The mechanism for the association may involve mo...

journal_title：Clinical and experimental dermatology

authors： Henderson CA,Highet AS

更新日期：1995-03-01 00:00:00

abstract：:Multiple cutaneous and uterine leiomyomata (MCL) is an autosomal dominant disorder characterized by the development of benign smooth muscle tumours (leiomyomas) in the skin and uterus of affected women, and in the skin of affected men. In rare cases, MCL has been associated with a predisposition to the rare type II pa...

journal_title：Clinical and experimental dermatology

authors： Chuang GS,Martinez-Mir A,Engler DE,Gmyrek RF,Zlotogorski A,Christiano AM

更新日期：2006-01-01 00:00:00

abstract：:Like many other cancers, melanoma has a significant genetic basis. However, its genetic pathways may involve multiple genes with probable interactions with sun exposure. Germline mutations in p16 or CDKN2A are found in a significant percentage of relatively rare melanoma families but p16 mutations are uncommon in spor...

journal_title：Clinical and experimental dermatology

authors： Bataille V

更新日期：2000-09-01 00:00:00

abstract：:This is the first of two articles on C1 inhibitor deficiency based on a recent UK consensus document covering diagnosis and management of the disorder in both adults and children. This paper focuses on diagnosis of this disorder. ...

journal_title：Clinical and experimental dermatology

authors： Gompels MM,Lock RJ

更新日期：2005-07-01 00:00:00

abstract：:In this study we used the nickel contact allergy patch (CAP) test to investigate the effect of topical corticosteroids on allergic contact dermatitis (ACD). On day 1, three CAP tests were applied for 48 h on the forearms of 20 female volunteers with a known nickel ACD. CAP of the right forearm contained 5% nickel, and...

journal_title：Clinical and experimental dermatology

authors： Hachem JP,De Paepe K,Vanpée E,Bogaerts M,Kaufman L,Rogiers V,Roseeuw D

更新日期：2002-01-01 00:00:00