Abstract:
BACKGROUND:The hyperactive melanocytes present in melasma skin are confined to the epidermis, but epidermal ablation to treat melasma pigmentation may lead to disease recurrence and aggravation. Melanocyte function is regulated by interactions between melanocytes and neighbouring cells such as keratinocytes and fibroblasts. Because melasma skin usually shows dermal changes after exposure to sunlight, we hypothesized that sun-damaged fibroblasts might play a crucial role in the pathogenesis of melasma. AIM:In this study, the melanogenic role of primary cultured fibroblasts from human melasma skin was investigated. METHODS:We explored whether primary cultured fibroblasts from melasma tissue have a melanogenic function on cultured human epidermal melanocytes and artificial skin. The cytokine profile derived from fibroblasts and their effect on the pigmented epidermal equivalents were investigated. RESULTS:Fibroblasts from the melasma lesion and perilesional skin increased melanogenesis in cultured human epidermal melanocytes and in artificial skin. Fibroblasts from the melasma lesion and perilesional skin secreted more nerve growth factor (NGF)-β than those in normal buttock skin, and also increased melanogenesis and the expression level of NGF-β in cultured human epidermal melanocytes and artificial skin. CONCLUSIONS:These results suggest that fibroblasts may play a role in melanogenesis and the pathogenesis of melasma.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Byun JW,Park IS,Choi GS,Shin Jdoi
10.1111/ced.12874subject
Has Abstractpub_date
2016-08-01 00:00:00pages
601-9issue
6eissn
0307-6938issn
1365-2230journal_volume
41pub_type
杂志文章abstract::Polymorphic eruption of pregnancy is an uncommon disorder, usually developing in the third trimester and rapidly resolving in the first few weeks postpartum. It has been suggested that multiple pregnancy and excessive weight gain are associated features. We report a patient with the clinical and histological features ...
journal_title:Clinical and experimental dermatology
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