Pure hair-nail ectodermal dysplasia maps to chromosome 12p11.1-q21.1 in a consanguineous Pakistani family.

abstract：BACKGROUND:Recently, a new population of IL-17-producing CD4 T helper (Th) cells, named Th17, was identified and shown to be involved in various inflammatory and autoimmune diseases, including psoriasis. AIM:To determine the frequency of Th17 cells and related cytokines in peripheral blood of patients with psoriasis, ...

journal_title：Clinical and experimental dermatology

authors： Chhabra S,Narang T,Joshi N,Goel S,Sawatkar G,Saikia B,Dogra S,Bansal F,Minz R

更新日期：2016-10-01 00:00:00

abstract：:An unusual giant combined dermatofibroma is reported in a 34-year-old man who presented with skin-coloured swellings on the medial aspect of the left scapula. The plaque was well defined, reddish-brown and 25-30 cm in diameter. It was also tender and indurated. Several similar smaller lesions (satellites) were present...

journal_title：Clinical and experimental dermatology

authors： Sehgal VN,Sardana K,Khandpur S,Sharma S,Majumdar S,Aggarwal AK

更新日期：2004-03-01 00:00:00

abstract：:Follicular mucinosis is a rare chronic inflammatory disease of unknown aetiology, presenting as mucin deposits around the follicles and sebaceous glands. It can progress to alopecia of the scalp and other hairy areas. Follicular mucinosis may be a benign primary idiopathic disorder or secondary to malignant lymphoprol...

journal_title：Clinical and experimental dermatology

authors： Passaro EM,Silveira MT,Valente NY

更新日期：2004-07-01 00:00:00

abstract：:A 68-year-old woman developed allergic contact dermatitis to topical metronidazole gel as proven by positive patch tests to the gel and to metronidazole. She was also allergic to methylchloroisothiazolinone and methylisothiazolinone (MC/MI). The similarity between the two molecules and the fact that the patient reacte...

journal_title：Clinical and experimental dermatology

authors： Wolf R,Orion E,Matz H

更新日期：2003-09-01 00:00:00

abstract：AIM:To evaluate the effectiveness of a silicone gel in treating surgical wounds compared with a control group of the same phenotype and same scar site for which a placebo was advised. METHODS:This was a randomized controlled trial, carried out in a dermatology department of a university hospital. In total, we studied ...

journal_title：Clinical and experimental dermatology

authors： de Giorgi V,Sestini S,Mannone F,Papi F,Alfaioli B,Gori A,Lotti T

更新日期：2009-08-01 00:00:00

abstract：:Recent studies have shown that the protein MIA (melanoma inhibitory activity) is a potent serum marker for malignant melanoma. MIA is expressed in chondrocytes at high levels, and might potentially be elevated during periods of growth in childhood. Therefore, we evaluated MIA serum levels in pregnant women and in grow...

journal_title：Clinical and experimental dermatology

authors： Bosserhoff AK,Küster H,Hein R

更新日期：2004-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) with topical 5-aminolaevulinic acid (5-ALA) is a promising new treatment for superficial malignant nonmelanoma tumours, including cutaneous malignant lymphoma. Here, we report a case of cutaneous anaplastic large cell lymphoma effectively treated by PDT with topical 5-ALA in combination with...

journal_title：Clinical and experimental dermatology

authors： Umegaki N,Moritsugu R,Katoh S,Harada K,Nakano H,Tamai K,Hanada K,Tanaka M

更新日期：2004-01-01 00:00:00

abstract：:Chromonychia induced by antineoplastic agents has been known for several years. The most frequent of these is melanonychia, either diffuse or in tranverse or longitudinal bands, that may co-exist with diffuse pigmentation of the skin. Although any cytostatic agent may be involved in melanonychia, this condition appear...

journal_title：Clinical and experimental dermatology

authors： Unamuno P,Fernández-López E,Santos C

更新日期：1992-07-01 00:00:00

abstract：:Netherton syndrome (NS) is a rare and severe autosomal recessive ichthyosis. We report the case of a patient with NS treated successfully with narrowband ultraviolet B (NB-UVB) phototherapy after failure of low-dose oral isotretinoin. A 16-year-old girl born to consanguineous parents presented with severe ichthyosis. ...

journal_title：Clinical and experimental dermatology

authors： Maatouk I,Moutran R,Tomb R

更新日期：2012-06-01 00:00:00

abstract：:Cutaneous amyloidosis and multiple endocrine neoplasia 2A (MEN 2A) have been previously reported in several families. A genetic linkage of both disorders has recently been described. Notalgia paraesthetica has been suggested to be involved in the aetiology of amyloidosis in such patients. We report such an association...

journal_title：Clinical and experimental dermatology

authors： de Argila D,Ortiz-Romero PL,Ortiz-Frutos J,Rodriguez-Peralto JL,Iglesias L

更新日期：1996-07-01 00:00:00

abstract：:Robert Willan is commemorated by a blue plaque on the house in which he lived in Bloomsbury Square in London. He lived there during a productive period of his career, until ill-health caused him to travel to Madeira, where he died. This fitting tribute to Willan is the result of the efforts of Dr. Henry MacCormac, him...

journal_title：Clinical and experimental dermatology

authors： Walker SL

更新日期：2011-08-01 00:00:00

abstract：:We report a case of follicular porokeratosis of Mibelli affecting the natal cleft in a 42-year-old white man. To our knowledge, this is the first report in the English-language literature of follicular porokeratosis of Mibelli limited to the genitogluteal area. ...

journal_title：Clinical and experimental dermatology

authors： Yong AS,Singh M,Goulding JM,Swale VJ

更新日期：2009-01-01 00:00:00

abstract：:We report the case of a 24-year-old woman with an 8-month history of deep pelvic pain and postcoital bleeding. Examination revealed desquamation of the vaginal epithelium with tender fissured plaques in the vagina, initially thought to be vaginal intraepithelial neoplasia. Histology showed squamous mucosa with supraba...

journal_title：Clinical and experimental dermatology

authors： Kentley J,Cerio R,Khorshid M,Gibbon K

更新日期：2017-03-01 00:00:00

abstract：:We wish to report the progress of a patient with pyoderma faciale and Crohn's disease. The patient is interesting in that on two occasions the relapse in her skin condition coincided with the introduction of non-steroidal anti-inflammatory drugs. Therapy with isotretinoin was effective and well tolerated. ...

journal_title：Clinical and experimental dermatology

authors： McHenry PM,Hudson M,Smart LM,Rennie JA,Mowat NA,White MI

更新日期：1992-11-01 00:00:00

abstract：:This is the first of two articles on C1 inhibitor deficiency based on a recent UK consensus document covering diagnosis and management of the disorder in both adults and children. This paper focuses on diagnosis of this disorder. ...

journal_title：Clinical and experimental dermatology

authors： Gompels MM,Lock RJ

更新日期：2005-07-01 00:00:00

abstract：:We report a 73-year-old man who developed repeated episodes of erythematous, bullous plaques beginning 3 months after discontinuation of combination treatment with pegylated interferon (IFN)-alpha-2b and ribavirin for hepatitis C virus infection. The first episode resolved within a week without treatment, but the lesi...

journal_title：Clinical and experimental dermatology

authors： Sato M,Sueki H,Iijima M

更新日期：2009-12-01 00:00:00

abstract：:Contact allergy to various essential oils used in aromatherapy was demonstrated on patch testing in a 53-year-old patient suffering from relapsing eczema resistant to therapy on various uncovered parts of the skin, in particular the scalp, neck and hands. Sensitization was due to previous exposure to lavender, jasmine...

journal_title：Clinical and experimental dermatology

authors： Schaller M,Korting HC

更新日期：1995-03-01 00:00:00

abstract：:A retrospective study was made of the incidence of cutaneous melanoma among the population of the district of Rijeka (Croatia) during the period 1977-96. A total of 397 patients with cutaneous melanoma was documented during this period. Over the 20-year period the incidence of the tumour increased, the mean annual rat...

journal_title：Clinical and experimental dermatology

authors： Zamolo G,Gruber F,Jonjić A,Cabrijan L,Palle M,Grubisić-Greblo H

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:In patients with psoriasis, videocapillaroscopy has been used to visualize the typical modifications in the microcirculatory architecture. AIM:To evaluate the modifications of the superficial capillary bed in a psoriatic plaque and healthy perilesional skin during treatment with a topical steroid. METHODS:...

journal_title：Clinical and experimental dermatology

authors： Stinco G,Lautieri S,Piccirillo F,Valent F,Patrone P

更新日期：2009-12-01 00:00:00

abstract：:It is a common experience that many Spitz naevi deviate from the idealized or stereotypical representation found in the literature, often causing considerable difficulties in distinguishing them from melanoma. The diagnostic term 'atypical Spitz naevus' is used to describe lesions that deviate from the typical appeara...

journal_title：Clinical and experimental dermatology

authors： de Giorgi V,Sestini S,Massi D,Papi F,Lotti T

更新日期：2008-05-01 00:00:00

abstract：:Ichthyosis hystrix, Curth-Macklin type (IHCM) is an extremely rare autosomal dominant dermatosis caused by mutations in the keratin genes, KRT1 or KRT10, which often manifests as extensive, dark, spiky or verrucous plaques and severe palmoplantar keratoderma. We report a novel frameshift truncation mutation, c.1596_15...

journal_title：Clinical and experimental dermatology

authors： Yang Z,Xu Z,Zhang N,Ma L

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive skin disease caused by mutations in the type VII collagen gene (COL7A1), resulting in detachment of the entire epidermis due to loss or hypoplasticity of the anchoring fibrils that normally secure the basement membrane to the underly...

journal_title：Clinical and experimental dermatology

authors： Hanafusa T,Tamai K,Umegaki N,Yamaguchi Y,Fukuda S,Nishikawa Y,Yaegashi N,Okuyama R,McGrath JA,Katayama I

更新日期：2012-01-01 00:00:00

abstract：:Neurotrophic ulceration of the face is a rare but well recognized sequel to division of the trigeminal nerve. Trauma is an important contributory factor and thought to be due in part to paraesthesiae, which encourages picking and scratching, with resultant chronic and persistent ulceration. A case is described of an 8...

journal_title：Clinical and experimental dermatology

authors： Mayer RD,Smith NP

更新日期：1993-03-01 00:00:00

abstract：:We report the case of a 43-year-old woman, a longstanding heavy cigarette smoker, who developed Bürger's disease, leading to mid-thigh amputation of her left leg. After she gave up smoking her disease was arrested but Raynaud's phenomenon continues to affect her hands and right foot. In reviewing the literature, we fo...

journal_title：Clinical and experimental dermatology

authors： Abdullah AN,Keczkes K

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Psoriasis involves a multifaceted interplay of keratinocytes, blood vessels, immune system mediators and expressed genes. AIM:To determine whether genetic polymorphisms in the angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2) and caspase-5 (CASP5) genes are associated with an increased risk of developing pso...

journal_title：Clinical and experimental dermatology

authors： He L,Dang L,Zhou J,Bai J,Li YZ

更新日期：2015-07-01 00:00:00

abstract：:Fourteen patients with psoriasis received long-term treatment with cyclosporin (CsA). Among patients there was great variability in the minimal effective CsA dose. In most patients long-term treatment was limited due to dose reductions made necessary because of side-effects. The therapeutic window for CsA seems small....

journal_title：Clinical and experimental dermatology

authors： Korstanje MJ,Van de Staak WJ

更新日期：1991-01-01 00:00:00

abstract：:This randomized double-blind controlled study examined whether sulphydryl-containing agents influence the healing of venous ulceration occurring for the first time on the medial side of the leg. Graduated compression bandaging, which exerted a mean ankle pressure of 40.6 +/- 0.4 mmHg, and a mean below-knee pressure of...

journal_title：Clinical and experimental dermatology

authors： Salim AS

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disease. The clinical presentation includes lack of sweating ability, and an often widely spread dermatitis resembling atopic dermatitis (AD). In AD, the skin-barrier defect is partly ascribed to the altered lipid profile in the stratum corneum and pa...

journal_title：Clinical and experimental dermatology

authors： Jungersted JM,Høgh JK,Hellgren LI,Agner T,Jemec GB

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:We conducted a re-audit of the surgical practice of UK dermatologists for the treatment of nonmelanoma skin cancer and examined changes with reference to our previous audit in 2014. The audit was supplemented by a detailed assessment of completeness of the histopathology reports for each tumour. METHODS:UK ...

journal_title：Clinical and experimental dermatology

authors： Keith DJ,Bray AP,Brain A,Mohd Mustapa MF,Barrett HE,Lane S,Emmerich M,Jakes A,Barrett PD,de Berker DAR

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Effective treatment options for morphoea remain limited. As a result, there has been increasing interest in the role of phototherapy in the management of this condition. Aims. We report the findings of a study in which 13 patients with localized morphoea were treated with oral (n = 11) and topical (n = 2) ps...

journal_title：Clinical and experimental dermatology

authors： Usmani N,Murphy A,Veale D,Goulden V,Goodfield M

更新日期：2008-11-01 00:00:00