Abstract:
:A questionable scientific approach to measuring at low concentrations and inappropriate censoring of results below certain cut-offs have resulted in the dichotomous classification of troponin assays based on their so-called analytical sensitivity. The definition of "high-sensitivity" cardiac troponin is flawed. Evidence suggests that its apparent diagnostic superiority may be explained by the censoring of data. In the evaluation of the detection and quantification capabilities of analytical methods we recommend alignment with International Union of Pure and Applied Chemistry (IUPAC) guidelines, including reporting of all results. This will allow the objective evaluation of the diagnostic performance of troponin assays and will render the current troponin assay classification and nomenclature obsolete.
journal_name
Clin Chem Lab Medjournal_title
Clinical chemistry and laboratory medicineauthors
Ungerer JPJ,Pretorius CJdoi
10.1515/cclm-2017-0025subject
Has Abstractpub_date
2017-10-26 00:00:00pages
1669-1671issue
11eissn
1434-6621issn
1437-4331pii
/j/cclm.ahead-of-print/cclm-2017-0025/cclm-2017-00journal_volume
55pub_type
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