Abstract:
:Using anti-human B cell monoclonal antibodies prepared against B1 (CD20), B2 (CD21), B4 (CD19), and BB-1 (B lymphoblast antigen-1), we compared the expression of B cell differentiation antigens on a Jijoye-P3HR-1 cell line family of Burkitt's lymphomas. The expression of BB-1 and B2 antigens was faint on P3HR-1 K cell line which is an Epstein-Barr virus (EBV) high producer. On the other hand, B1 and B4 antigens were strongly expressed on it. It was also found that BB-1 expression decreased on P3HR-1 cells after activation of intracellular EBV genes by treating chemically with tumor-promoting agent (TPA) and n-butyrate, or on Raji cells on superinfection with EBV. This decrease of BB-1 was blocked by the additional treatment with retinoic acid, an inhibitor of virus replication. Dual immunofluorescence staining analysis showed that the individual cell expressing EBV-associated antigens expressed BB-1 antigen only marginally. The relationship between the change in phenotypes of host B cells and the activation of the EBV genome is discussed.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Yokochi T,Inoue Y,Iwata H,Miyadai T,Kimura Ydoi
10.1111/j.1348-0421.1988.tb01457.xsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
957-64issue
9eissn
0385-5600issn
1348-0421journal_volume
32pub_type
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journal_title:Microbiology and immunology
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