Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury.

abstract：:The lipid bilayer of the plasma membrane is a selective impermeable barrier for the internalization of most macromolecules. Cell penetrating peptides (CPPs) could cross the plasma membrane barrier to deliver various molecules into cells and are considered as a promising tool to deliver macromolecular drugs. However, t...

journal_title：Current protein & peptide science

authors： Zhu P,Jin L

更新日期：2018-01-01 00:00:00

abstract：:Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing "treasure trove" o...

journal_title：Current protein & peptide science

authors： Wilson DN,Blaha G,Connell SR,Ivanov PV,Jenke H,Stelzl U,Teraoka Y,Nierhaus KH

更新日期：2002-02-01 00:00:00

abstract：:Mites and ticks are associated with many human diseases including allergic diseases and scabies. With the recent advances in the high throughput DNA sequencing technology, many mitochondrial nuclear genomes of these species have been sequenced and the resulting genomic resources will certainly provide novel insights f...

journal_title：Current protein & peptide science

authors： Xiong Q,Wan ATY,Tsui SK

更新日期：2020-01-01 00:00:00

abstract：:Viscosity of protein solution is one of the most troublesome issues for the high-concentration formulation of protein drugs. In this review, we summarize the practical methods that suppress the viscosity of protein solution using small molecular additives. The small amount of salts decreases the viscosity that results...

journal_title：Current protein & peptide science

authors： Hong T,Iwashita K,Shiraki K

更新日期：2018-01-01 00:00:00

abstract：:The complement system is a major effector arm of the immune defense contributing to the destruction of invading pathogens. There are three possible routes of complement cascade activation: the classical, the alternative and the lectin pathways. The activation of the classical and lectin pathways is initiated by supram...

journal_title：Current protein & peptide science

authors： Gál P,Ambrus G

更新日期：2001-03-01 00:00:00

abstract：:Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive thera...

journal_title：Current protein & peptide science

authors： Lyu C,Fang F,Li B

更新日期：2019-01-01 00:00:00

abstract：:The review presents three hypotheses concerning the amino acid complementarity: 1) the Mekler-Blalock antisense hypothesis; 2) the Root-Bernstein approach based on stereochemical complementarity of amino acids and anti-amino acids coded by anticodons read in parallel with the coding DNA strand; 3) Siemion hypothesis r...

journal_title：Current protein & peptide science

authors： Siemion IZ,Cebrat M,Kluczyk A

更新日期：2004-12-01 00:00:00

abstract：:NOD Like Receptors (NLRs) are the most abundant cytoplasmic immune receptors in plants and animals and they similarly act sensing pathogen invasion and activating immune response. Despite the fact that plant and mammals NLRs share homology.; with some protein structure differences.; for signalling pathway.; divergent ...

journal_title：Current protein & peptide science

authors： Pontillo A,Crovella S

更新日期：2017-01-01 00:00:00

abstract：:Fungal diseases are severe and have very high morbidity as well as up to 60% mortality for patients diagnosed with invasive fungal infection. In this review, in vitro and in vivo studies provided us with the insight into the role of Candida virulence factors that mediate their success as pathogens, such as: membrane a...

journal_title：Current protein & peptide science

authors： Staniszewska M

更新日期：2020-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are type I transmembrane signaling molecules that are expressed in cells of the innate immune system. In these cells, TLRs function as pattern recognition receptors (PRR) that recognize specific molecular patterns derived from microorganisms. Upon activation, TLRs trigger a cascade of intrac...

journal_title：Current protein & peptide science

authors： Lee H,Lee S,Cho IH,Lee SJ

更新日期：2013-02-01 00:00:00

abstract：:X-box binding protein 1 (XBP-1) is a key regulator of the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum (ER) stress. Cells contain two protein isoforms of XBP-1, the active isoform (XBP-1S) and the inactive isoform (XBP-1U). Induction of UPR leads to the generation of XBP-1S ...

journal_title：Current protein & peptide science

authors： Ong HK,Soo BPC,Chu KL,Chao SH

更新日期：2018-01-01 00:00:00

abstract：:Identifying the interactions between drugs and target proteins is a key step in drug discovery. This not only aids to understand the disease mechanism, but also helps to identify unexpected therapeutic activity or adverse side effects of drugs. Hence, drug-target interaction prediction becomes an essential tool in the...

journal_title：Current protein & peptide science

authors： Anusuya S,Kesherwani M,Priya KV,Vimala A,Shanmugam G,Velmurugan D,Gromiha MM

更新日期：2018-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in th...

journal_title：Current protein & peptide science

authors： Wang X,Xu L,Lao Y,Zhang H,Xu H

更新日期：2018-02-13 00:00:00

abstract：:Despite a wide variety of biological functions, alpha-helical membrane proteins display a rather simple transmembrane architecture. Although not many high resolution structures of transmembrane proteins are available today, our understanding of membrane protein folding has emerged in the recent years. Now we begin to ...

journal_title：Current protein & peptide science

authors： Schneider D,Finger C,Prodöhl A,Volkmer T

更新日期：2007-02-01 00:00:00

abstract：:Lipolytic enzymes catalyze the hydrolysis of ester bonds in the presence of water. In media with low water content or in organic solvents, they can catalyze synthetic reactions such as esterification and transesterification. Lipases and esterases, in particular those from extremophilic origin, are robust enzymes, func...

journal_title：Current protein & peptide science

authors： López-López O,Cerdán ME,González Siso MI

更新日期：2014-01-01 00:00:00

abstract：:The majority of tRNA studies has focused on tRNA molecules as pivotal player in the fundamental process of protein synthesis. Mounting studies have unveiled further functions for tRNA beyond protein synthesis, including non-ribosomal amino acid transfer, and regulation of targeted proteolysis. Post-translational N-ter...

journal_title：Current protein & peptide science

authors： Eldeeb MA,Ragheb MA

更新日期：2018-01-01 00:00:00

abstract：:An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...

journal_title：Current protein & peptide science

authors： Jeon SH

更新日期：2020-01-01 00:00:00

abstract：:TOYOPEARL particles are cross-linked hydroxylated methacrylic polymers available in different pore and particle sizes. They are conjugated with different ligands to generate ion-exchange, hydrophobic interaction and affinity resins. They have excellent physical and chemical properties. A mixed-mode resin, TOYOPEARL MX...

journal_title：Current protein & peptide science

authors： Arakawa T

更新日期：2019-01-01 00:00:00

abstract：:Skeletal muscle, the main protein reservoir in the body, is a tissue that exhibits high plasticity when exposed to changes. Muscle proteins can be mobilized into free amino acids when skeletal muscle wasting occurs, a process called skeletal muscle atrophy. This wasting is an important systemic or local manifestation ...

journal_title：Current protein & peptide science

authors： Cabello-Verrugio C,Córdova G,Salas JD

更新日期：2012-09-01 00:00:00

abstract：:Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...

journal_title：Current protein & peptide science

authors： Turra D,Lorito M

更新日期：2011-08-01 00:00:00

abstract：:This article is a continuation of a series of reviews on the presence and the role of intrinsic disorder in milk proteins in the journal of Current Protein and Peptide Science. The focus of this article is on casein phosphopeptides, which are liberated during digestion of the milk protein casein. Structurally these ph...

journal_title：Current protein & peptide science

authors： Naqvi MA,Irani KA,Katanishooshtari M,Rousseau D

更新日期：2016-01-01 00:00:00

abstract：:Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...

journal_title：Current protein & peptide science

authors： Wong JH,Xia L,Ng TB

更新日期：2007-10-01 00:00:00

abstract：:Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment, and eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of b...

journal_title：Current protein & peptide science

authors： Zhang W,Zhang Y,Zheng Y,Zheng M,Sun N,Yang X,Gao Y

更新日期：2019-01-01 00:00:00

abstract：:The absence of uracil from DNA genomes is a consequence of enzyme functions that eliminate intracellular dUTP pools and that purposefully recognize and remove uracil moieties from DNA. These enzymatic functions are dUTP nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UDG), respectively. There are distinct nu...

journal_title：Current protein & peptide science

authors： Caradonna S,Muller-Weeks S

更新日期：2001-12-01 00:00:00

abstract：:The fluorinated alcohol 2,2,2-Trifluoroethanol (TFE) has been implemented for many decades now in conformational studies of proteins and peptides. In peptides, which are often disordered in aqueous solutions, TFE acts as secondary structure stabilizer and primarily induces an α -helical conformation. The exact mechani...

journal_title：Current protein & peptide science

authors： Vincenzi M,Mercurio FA,Leone M

更新日期：2019-01-01 00:00:00

abstract：:The number of protein folds in nature is limited, thus is not surprising that proteins with the same fold are able to exert different functions. The cysteine protease inhibitors that adopt an immunoglobulin- like fold (Ig-ICPs) are inhibitors encoded in bacteria and protozoan parasites. Structural studies indicate tha...

journal_title：Current protein & peptide science

authors： Jimenez-Sandoval P,Lopez-Castillo LM,Trasviña-Arenas CH,Brieba LG

更新日期：2017-01-01 00:00:00

abstract：:To defend themselves from attack by pathogens, plants can rely only on their innate defense systems. Defensins are antimicrobial peptides that contribute to plant immunity by displaying a direct cidal activity against various pathogens, some of which are responsible for plant diseases. These determine a significant de...

journal_title：Current protein & peptide science

authors： Padovan L,Crovella S,Tossi A,Segat L

更新日期：2010-05-01 00:00:00

abstract：:Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of bioge...

journal_title：Current protein & peptide science

authors： Fan P,Song P,Li L,Huang C,Chen J,Yang W,Qiao S,Wu G,Zhang G,Ma X

更新日期：2017-01-01 00:00:00

abstract：:Heart failure (HF) is a condition with high mortality worldwide characterized by persistent progression. Myocardial hypertrophy is a dominant feature during the early stage of HF. The development of HF is a complex process related to a series of physiologic and molecular factors. Although the treatment of HF has been ...

journal_title：Current protein & peptide science

authors： Bi Q

更新日期：2012-11-01 00:00:00

abstract：:The interactions of ligands with biomacromolecules play a fundamental role in almost all bioprocesses occuring in living organisms. The binding of ligands can cause the conformational changes of biomacromolecules, possibly affecting their physiological functions. The interactions of ligands with biomacromolecules are ...

journal_title：Current protein & peptide science

authors： Zhang W,Pan L,Wang H,Lv X,Ding K

更新日期：2017-01-01 00:00:00