Anti-Tumor Effects of Melittin and Its Potential Applications in Clinic.

abstract：:The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of pro...

journal_title：Current protein & peptide science

authors： Veljkovic N,Glisic S,Prljic J,Perovic V,Botta M,Veljkovic V

更新日期：2008-10-01 00:00:00

abstract：:An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...

journal_title：Current protein & peptide science

authors： Jeon SH

更新日期：2020-01-01 00:00:00

abstract：:This article is a continuation of a series of reviews on the presence and the role of intrinsic disorder in milk proteins in the journal of Current Protein and Peptide Science. The focus of this article is on casein phosphopeptides, which are liberated during digestion of the milk protein casein. Structurally these ph...

journal_title：Current protein & peptide science

authors： Naqvi MA,Irani KA,Katanishooshtari M,Rousseau D

更新日期：2016-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in th...

journal_title：Current protein & peptide science

authors： Wang X,Xu L,Lao Y,Zhang H,Xu H

更新日期：2018-02-13 00:00:00

abstract：:In spite of the relevance of the results obtained through the clinical application of chemotherapeutic agents (reverse transcriptase and proteinase inhibitors) that are able to prolong the life span of affected people, acquired immunodeficiency syndrome (AIDS) remains a serious and lethal disease. AIDS is caused by a ...

journal_title：Current protein & peptide science

authors： Di Bello C,Pasquato A,Dettin M

更新日期：2004-08-01 00:00:00

abstract：:Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of bioge...

journal_title：Current protein & peptide science

authors： Fan P,Song P,Li L,Huang C,Chen J,Yang W,Qiao S,Wu G,Zhang G,Ma X

更新日期：2017-01-01 00:00:00

abstract：:This work briefly describes available sensors for cAMP and cGMP. Many sensors are based on derivatization of naturally occurring products such as immunoglobulins, protein kinases, etc. Only a few published works deal with chemosensors, which are built up by "total" chemical synthesis. This field stays opened for combi...

journal_title：Current protein & peptide science

authors： Sebestík J,Hlavácek J,Stibor I

更新日期：2005-04-01 00:00:00

abstract：:Glycoconjugates comprise a variety of structures, include glycoproteins and glycolipids and are found on the surfaces of animal and plant cells, as well as on the surface of microorganisms. Determination of the structure and the distribution of glycoconjugates on cell surfaces are important for the understanding their...

journal_title：Current protein & peptide science

authors： Naeem A,Saleemuddin M,Khan RH

更新日期：2007-06-01 00:00:00

abstract：:SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...

journal_title：Current protein & peptide science

authors： Korsinczky ML,Schirra HJ,Craik DJ

更新日期：2004-10-01 00:00:00

abstract：:The number of protein folds in nature is limited, thus is not surprising that proteins with the same fold are able to exert different functions. The cysteine protease inhibitors that adopt an immunoglobulin- like fold (Ig-ICPs) are inhibitors encoded in bacteria and protozoan parasites. Structural studies indicate tha...

journal_title：Current protein & peptide science

authors： Jimenez-Sandoval P,Lopez-Castillo LM,Trasviña-Arenas CH,Brieba LG

更新日期：2017-01-01 00:00:00

abstract：:By utilizing recently developed full-length cDNA technologies, large-scale cDNA sequencing was carried out by several cDNA projects. Now full-length cDNA resources cover the major part of the protein-coding human genes. Comprehensive analyses of the collected full-length cDNA data revealed not only the complete sequen...

journal_title：Current protein & peptide science

authors： Suzuki Y,Sugano S

更新日期：2006-04-01 00:00:00

abstract：:Evidence is accumulating that small open reading frames (sORF, <100 codons) play key roles in many important biological processes. Yet, they are generally ignored in gene annotation despite they are far more abundant than the genes with more than 100 codons. Here, we demonstrate that popular homolog search and codon-i...

journal_title：Current protein & peptide science

authors： Cheng H,Chan WS,Li Z,Wang D,Liu S,Zhou Y

更新日期：2011-09-01 00:00:00

abstract：:Structural and theoretical analyses of proteins are central to the understanding of complex molecular mechanisms and are fundamental to the drug discovery process. Computational techniques yield useful insights into an ever-wider range of biomolecular systems. Protein three-dimensional structures and molecular functio...

journal_title：Current protein & peptide science

authors： Villoutreix BO

更新日期：2002-06-01 00:00:00

abstract：:Prostate cancer is one of the major threats to the man's health. There are several mechanisms of the prostate cancer development characterized by the involvement of various androgen-related and androgen-unrelated factors in prostate cancer pathogenesis and in the metastatic carcinogenesis of prostate. In all these pro...

journal_title：Current protein & peptide science

authors： Uversky VN,Na I,Landau KS,Schenck RO

更新日期：2017-01-01 00:00:00

abstract：:The aggregation of proteins or their digested fragments through β-sheet structures has a great significance because it leads to neurodegenerative diseases, which are a problem of the aging societies of the developed countries. Short peptides are typically used as models to study the formation of specific structures. H...

journal_title：Current protein & peptide science

authors： Makowska J

更新日期：2017-01-01 00:00:00

abstract：:Alpha-fetoprotein (AFP), known largely as a growth-promoting agent, possesses a growth-inhibitory motif recently identified as an occult epitopic segment in the third domain. The present study reviews the multiple biological activities of this AFP-derived peptide segment termed the Growth Inhibitory Peptide (GIP), whi...

journal_title：Current protein & peptide science

authors： Mizejewskia GJ,Butterstein G

更新日期：2006-02-01 00:00:00

abstract：:Membrane proteins play important roles in signal transduction across the cell membrane. Structural information for the membrane proteins is still limited due to many technical challenges. Membrane proteins containing a single α- helical transmembrane (TM) domain are very important in several pathways. Solution NMR spe...

journal_title：Current protein & peptide science

authors： Gayen S,Li Q,Kang C

更新日期：2012-09-01 00:00:00

abstract：:The cytolysin is a novel, two-peptide lytic toxin produced by some strains of Enterococcus faecalis. It is toxic in animal models of enterococcal infection, and associated with acutely terminal outcome in human infection. The cytolysin exerts activity against a broad spectrum of cell types including a wide range of gr...

journal_title：Current protein & peptide science

authors： Cox CR,Coburn PS,Gilmore MS

更新日期：2005-02-01 00:00:00

abstract：:Despite a wide variety of biological functions, alpha-helical membrane proteins display a rather simple transmembrane architecture. Although not many high resolution structures of transmembrane proteins are available today, our understanding of membrane protein folding has emerged in the recent years. Now we begin to ...

journal_title：Current protein & peptide science

authors： Schneider D,Finger C,Prodöhl A,Volkmer T

更新日期：2007-02-01 00:00:00

abstract：:This review is to summarize three new QSAR (quantitative structure-activity relationship) methods recently developed in our group and their applications for drug design. Based on more solid theoretical models and advanced mathematical techniques, the conventional QSAR technique has been recast in the following three a...

journal_title：Current protein & peptide science

authors： Du QS,Huang RB,Chou KC

更新日期：2008-06-01 00:00:00

abstract：:The plasma membrane Ca2+ ATPases (PMCAs) are responsible for the clearance of Ca2+ out of cells after intracellular Ca2+ transients. Cooperating with Na+/Ca2+ exchangers (NCXs) and Ca2+ buffering proteins, PMCAs play an essential role in maintaining the long-term cellular Ca2+ homeostasis. The plasma membrane Ca2+ ATP...

journal_title：Current protein & peptide science

authors： Wu X,Weng L,Zhang J,Liu X,Huang J

更新日期：2018-01-01 00:00:00

abstract：:Cardiovascular (CV) diseases are caused by vascular dysfunction. The enhanced sensitivity to vasoconstrictors, reduced endothelium-derived vasodilators nitric oxide (NO) and prostacyclin (PGI2), and endothelium-derived hyperpolarization (EDH) indicate CV dysfunction. In recent years, recombinant human relaxin, known a...

journal_title：Current protein & peptide science

authors： Murtaza G,Siddiqui A,Hussain I

更新日期：2018-01-01 00:00:00

abstract：:Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledg...

journal_title：Current protein & peptide science

authors： Kishan KV

更新日期：2007-08-01 00:00:00

abstract：:Lipolytic enzymes catalyze the hydrolysis of ester bonds in the presence of water. In media with low water content or in organic solvents, they can catalyze synthetic reactions such as esterification and transesterification. Lipases and esterases, in particular those from extremophilic origin, are robust enzymes, func...

journal_title：Current protein & peptide science

authors： López-López O,Cerdán ME,González Siso MI

更新日期：2014-01-01 00:00:00

abstract：:Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...

journal_title：Current protein & peptide science

authors： Kentsis A,Borden KL

更新日期：2000-07-01 00:00:00

abstract：:For several decades the specificity of proteases has been presented as an active site divided into subsites, using the nomenclature of Schechter & Berger from 1967 (S1, S2... for subsites of the active site; P1, P2... for residues of the substrate occupying the corresponding subsites). At early stages of the research ...

journal_title：Current protein & peptide science

authors： Schechter I

更新日期：2005-12-01 00:00:00

abstract：:Staphylococcus aureus is a major cause of infection in humans and animals, causing a wide variety of diseases, from local inflammations to fatal sepsis. The bacterium is commonly multi-drug resistant and thus many front-line antibiotics have been rendered ineffective for treating such infections. Research on murein/pe...

journal_title：Current protein & peptide science

authors： Keary R,Sanz-Gaitero M,van Raaij MJ,O'Mahony J,Fenton M,McAuliffe O,Hill C,Ross RP,Coffey A

更新日期：2016-01-01 00:00:00

abstract：:Efforts to use computers in predicting the secondary structure of proteins based only on primary structure information started over a quarter century ago [1-3]. Although the results were encouraging initially, the accuracy of the pioneering methods generally did not attain the level required for using predictions of s...

journal_title：Current protein & peptide science

authors： Heringa J

更新日期：2000-11-01 00:00:00

abstract：:We compare the DNA-interactive properties of bacteriophage T4 gene 32 protein (gp32) with those of crotamine, a component of the venom of the South American rattlesnake. Gene 32 protein is a classical single-stranded DNA binding protein that has served as a model for this class of proteins. We discuss its biological f...

journal_title：Current protein & peptide science

authors： Karpel RL

更新日期：2015-01-01 00:00:00

abstract：:Fibroids or myomas involve large proportion of women of reproductive age. The myoma formation starts from the transformation of the myometrium, causing the progressive formation of a pseudocapsule, which is made of compressed muscle fibers. Numerous studies investigated on myoma pseudocapsule anatomy, discovering many...

journal_title：Current protein & peptide science

authors： Tinelli A,Mynbaev OA,Sparic R,Vergara D,Di Tommaso S,Salzet M,Maffia M,Malvasi A

更新日期：2017-01-01 00:00:00