Mapping of the active site of proteases in the 1960s and rational design of inhibitors/drugs in the 1990s.

abstract：:Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved m...

journal_title：Current protein & peptide science

authors： Rabbani G,Baig MH,Ahmad K,Choi I

更新日期：2018-01-01 00:00:00

abstract：:Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is implicated as a major etiologic agent of adult periodontal disease. This bacterium is asaccharolytic and possesses strong potency for proteolysis. It produces a novel class of cysteine proteinases, termed gingipains, in the cell-associated and sec...

journal_title：Current protein & peptide science

authors： Kadowaki T,Yamamoto K

更新日期：2003-12-01 00:00:00

abstract：:Changes in protein structure and function, alteration in protein-protein interaction, and significant difference in protein concentration inside the body could play an important role in indicating the pathological evidence of abnormalities before the development of clinical symptoms and act as a critical detection and...

journal_title：Current protein & peptide science

authors： Puranik N,Yadav D,Yadav SK,Chavda VK,Jin JO

更新日期：2020-01-01 00:00:00

abstract：:Proteasomes are the major nonlysosomal protein degradation machinery in eukaryotic cells and they are largely responsible for the processing of antigens for presentation by the MHC class I pathway. This review concentrates on recent developments in the area of antigen processing. Specialized proteasomes called immunop...

journal_title：Current protein & peptide science

authors： Rivett AJ,Hearn AR

更新日期：2004-06-01 00:00:00

abstract：:Cell viability depends on the correct folding of the proteins involved in metabolism. Proteins are synthesized on the endoplasmic reticulum and must follow a pathway to a correct, metastable, tridimensional structure. Changes in structure or in environmental conditions can drive an instability of the folding condition...

journal_title：Current protein & peptide science

authors： de la Arada I,Andraka N,Pacios MG,Arrondo JL

更新日期：2011-05-01 00:00:00

abstract：:Photosynthetic organisms and isolated photosystems are of interest for technical applications. In nature, photosynthetic electron transport has to work efficiently in contrasting environments such as shade and full sunlight at noon. Photosynthetic electron transport is regulated on many levels, starting with the energ...

journal_title：Current protein & peptide science

authors： Roach T,Krieger-Liszkay A

更新日期：2014-01-01 00:00:00

abstract：:Hemoglobin (Hb) is the prototypical example of a cooperative protein. Cooperativity of Hb is largely accounted for by the oxygen-linked allosteric interconversion between the T and R states/structures. Allostery is such a powerful explanation of Hb cooperativity that the possibility of cooperative events occurring wit...

journal_title：Current protein & peptide science

authors： Bellelli A

更新日期：2018-01-01 00:00:00

abstract：:This work briefly describes available sensors for cAMP and cGMP. Many sensors are based on derivatization of naturally occurring products such as immunoglobulins, protein kinases, etc. Only a few published works deal with chemosensors, which are built up by "total" chemical synthesis. This field stays opened for combi...

journal_title：Current protein & peptide science

authors： Sebestík J,Hlavácek J,Stibor I

更新日期：2005-04-01 00:00:00

abstract：:By utilizing recently developed full-length cDNA technologies, large-scale cDNA sequencing was carried out by several cDNA projects. Now full-length cDNA resources cover the major part of the protein-coding human genes. Comprehensive analyses of the collected full-length cDNA data revealed not only the complete sequen...

journal_title：Current protein & peptide science

authors： Suzuki Y,Sugano S

更新日期：2006-04-01 00:00:00

abstract：:Prediction of protein domain boundaries is an important step for the prediction of three-dimensional structure. The simple method PDP has been elaborated for prediction of the number and position of domain boundaries in multi-domain proteins by use of amino acid sequence alone. The method uses an optimized scale based...

journal_title：Current protein & peptide science

authors： Dovidchenko NV,Lobanov MY,Galzitskaya OV

更新日期：2007-04-01 00:00:00

abstract：:This article is a continuation of a series of reviews on the presence and the role of intrinsic disorder in milk proteins in the journal of Current Protein and Peptide Science. The focus of this article is on casein phosphopeptides, which are liberated during digestion of the milk protein casein. Structurally these ph...

journal_title：Current protein & peptide science

authors： Naqvi MA,Irani KA,Katanishooshtari M,Rousseau D

更新日期：2016-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Rehmanniae Radix Praeparata (RRP) is a popular medicinal herb widely used in traditional Chinese medicine (TCM) to treat CVDs. However, the development of this novel therapeutic product has been stagnant, and its molecular mechanism of action...

journal_title：Current protein & peptide science

authors： Zhang X,Wang D,Ren X,Atanasov AG,Zeng R,Huang L

更新日期：2019-01-01 00:00:00

abstract：:The absence of uracil from DNA genomes is a consequence of enzyme functions that eliminate intracellular dUTP pools and that purposefully recognize and remove uracil moieties from DNA. These enzymatic functions are dUTP nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UDG), respectively. There are distinct nu...

journal_title：Current protein & peptide science

authors： Caradonna S,Muller-Weeks S

更新日期：2001-12-01 00:00:00

abstract：:Tic, short for 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, is a kind of unnatural α-amino acids. Due to its distinct geometrical conformation and biological activity, the structure of Tic, regarded as the surrogate of proline and the rigid analogue of phenylalanine or tyrosine, has been introduced into many comp...

journal_title：Current protein & peptide science

authors： Zhang Y,Fang H,Xu W

更新日期：2010-12-01 00:00:00

abstract：:Evidence is accumulating that small open reading frames (sORF, <100 codons) play key roles in many important biological processes. Yet, they are generally ignored in gene annotation despite they are far more abundant than the genes with more than 100 codons. Here, we demonstrate that popular homolog search and codon-i...

journal_title：Current protein & peptide science

authors： Cheng H,Chan WS,Li Z,Wang D,Liu S,Zhou Y

更新日期：2011-09-01 00:00:00

abstract：:The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variatio...

journal_title：Current protein & peptide science

authors： Wright LR,Rothbard JB,Wender PA

更新日期：2003-04-01 00:00:00

abstract：:Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli due to infection and cellular stress have identified to play a vital role in the progr...

journal_title：Current protein & peptide science

authors： Sharma I,Behl T,Bungau S,Sachdeva M,Kumar A,Zengin G,Arora S

更新日期：2020-12-08 00:00:00

abstract：:PDZ domains are versatile protein interaction modules with the ability to dimerize and to recognize internal and carboxy-terminal peptide motifs. Their function in mediating the formation of multi-molecular signaling complexes is best understood at neuronal and epithelial membranes. In a screen for interactors that re...

journal_title：Current protein & peptide science

authors： Thomas MK,Tsang SW,Yeung ML,Leung PS,Yao KM

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:In the search of bioactive molecules, nature has always been an important source and most of the drugs in clinic are either natural products or derived from natural products. The ocean has played significant role as thousands of molecules and their metabolites with different types of biological activity such...

journal_title：Current protein & peptide science

authors： Negi B,Kumar D,Rawat DS

更新日期：2017-01-01 00:00:00

abstract：:Dietary protein from fermented cottonseed meal (FCSM), widely used in poultry diets in China, had regulating effects on lipid metabolism. To understand the effects of FCSM on lipid metabolism in broilers, we analyzed the biochemical indexes, enzyme activity, hormone level and metabolites in serum responses to FCSM int...

journal_title：Current protein & peptide science

authors： Nie C,Wang Y,Liu Y,Liu J,Ge W,Ma X,Zhang W

更新日期：2020-01-01 00:00:00

abstract：:Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages--the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagn...

journal_title：Current protein & peptide science

authors： Singh B,Singh S,Asif AR,Oellerich M,Sharma GL

更新日期：2014-01-01 00:00:00

abstract：:Arginine is widely used in such applications as protein refolding, solubilization of proteins and small molecules, protein and small molecule formulation, column chromatography and viral inactivation as summarized in this review. What makes arginine effective in these applications is largely based on its ability to su...

journal_title：Current protein & peptide science

authors： Arakawa T,Kita Y

更新日期：2014-01-01 00:00:00

abstract：:MEP (mercapto-ethyl-pyridine) HyperCel is one of the hydrophobic charge induction chromatography (HCIC) resins. Under normal operation, proteins are bound to the MEP resin at neutral pH, at which MEP is not charged, mostly via hydrophobic interaction. MEP has a pyridine group, whose pK is 4.8, and hence is positively ...

journal_title：Current protein & peptide science

authors： Arakawa T,Tokunaga M,Maruyama T,Shiraki K

更新日期：2019-01-01 00:00:00

abstract：:Membrane proteins play important roles in signal transduction across the cell membrane. Structural information for the membrane proteins is still limited due to many technical challenges. Membrane proteins containing a single α- helical transmembrane (TM) domain are very important in several pathways. Solution NMR spe...

journal_title：Current protein & peptide science

authors： Gayen S,Li Q,Kang C

更新日期：2012-09-01 00:00:00

abstract：:Fibroids or myomas involve large proportion of women of reproductive age. The myoma formation starts from the transformation of the myometrium, causing the progressive formation of a pseudocapsule, which is made of compressed muscle fibers. Numerous studies investigated on myoma pseudocapsule anatomy, discovering many...

journal_title：Current protein & peptide science

authors： Tinelli A,Mynbaev OA,Sparic R,Vergara D,Di Tommaso S,Salzet M,Maffia M,Malvasi A

更新日期：2017-01-01 00:00:00

abstract：:The High mobility group box 1 (HMGB1) protein is an extremely versatile, highly conserved nuclear protein, with its unique intracellular and extracellular functions mediated by its relatively simple domain structure. Within the nucleus, HMGB1 binds to DNA minor groove in a nonspecific manner and causes bends in the do...

journal_title：Current protein & peptide science

authors： Lohani N,Rajeswari MR

更新日期：2016-01-01 00:00:00

abstract：:Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)- type E3 ubiquitin ligase and also having SCF-independent activities. Mutations within FBXO7 have been found to cause an early-onset Parkinson's disease, and these are found within or near to its functional domains, including its F-...

journal_title：Current protein & peptide science

authors： Randle SJ,Laman H

更新日期：2017-01-01 00:00:00

abstract：:STATs promote fundamental cellular processes, marking them as convergence points of many oncogenic and inflammatory pathways. Therefore, aberrant activation of STAT signaling is implicated in a plethora of human diseases, like cancer, inflammation and auto-immunity. Identification of STAT-specific inhibitors is the to...

journal_title：Current protein & peptide science

authors： Szelag M,Wesoly J,Bluyssen HA

更新日期：2016-01-01 00:00:00

abstract：:Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment, and eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of b...

journal_title：Current protein & peptide science

authors： Zhang W,Zhang Y,Zheng Y,Zheng M,Sun N,Yang X,Gao Y

更新日期：2019-01-01 00:00:00

abstract：:Alpha-fetoprotein (AFP), known largely as a growth-promoting agent, possesses a growth-inhibitory motif recently identified as an occult epitopic segment in the third domain. The present study reviews the multiple biological activities of this AFP-derived peptide segment termed the Growth Inhibitory Peptide (GIP), whi...

journal_title：Current protein & peptide science

authors： Mizejewskia GJ,Butterstein G

更新日期：2006-02-01 00:00:00