Abstract:
:Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli due to infection and cellular stress have identified to play a vital role in the progression of cardiovascular disorders and thus, causing various symptoms like angina pectoris. Nlrp3 inflammasome, a key contributor in the pathogenesis of angina pectoris, requires activation and primary signaling for the commencement of inflammation. Nlrp3 inflammasome elicit out an inflammatory response by emission of pro inflammatory cytokines by ROS (reactive oxygen species) production, mobilization of K+ efflux and Ca2+ and by activation of lysosome destabilization that eventually causes pyroptosis, a programmed cell death process. Thus, inflammasome are considered to be one of the factors involved in the progression of coronary artery diseases and have an intricate role in development of angina pectoris.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Sharma I,Behl T,Bungau S,Sachdeva M,Kumar A,Zengin G,Arora Sdoi
10.2174/1389203721999201208200242subject
Has Abstractpub_date
2020-12-08 00:00:00eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-112184pub_type
杂志文章abstract::Pathogenic aggregation is closely associated with various protein misfolding diseases such as type 2 diabetes mellitus and Alzheimer's disease. Amyloidogenic proteins that have a propensity to assemble into amyloid oligomers and fibrils form the aggregates. The tumor suppressor p53, a transcription factor that regulat...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:
更新日期:2015-01-01 00:00:00
abstract::Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledg...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203053027557
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140221123105
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203023380657
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abstract::Here we review the present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea. Based on biochemical and structural studies, these proteins were originally assigned a role in the structural organization of chromatin; Sac10...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920312800785067
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666170106104211
更新日期:2018-02-13 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920308784534005
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920311796957667
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203013381152
更新日期:2001-06-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203003381324
更新日期:2000-11-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920305774933286
更新日期:2005-12-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920312803582933
更新日期:2012-09-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379594
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abstract::Cardiomyocytes are best known for their spontaneous beating activity, large cell size, and low regenerative capacity during adulthood. The mechanical activity of cardiomyocytes depends on a sophisticated contractile apparatus comprised of sarcomeres whose rhythmic contraction relies on Ca(2+) transients with a high le...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140331111518
更新日期:2014-05-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203023380846
更新日期:2002-02-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章
doi:10.2174/138920371701151130203441
更新日期:2016-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666151201191658
更新日期:2016-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920308786733930
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666171030103310
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203719666180809113122
更新日期:2018-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920307779941578
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379774
更新日期:2004-06-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203023380512
更新日期:2002-10-01 00:00:00
abstract::Telobox is a Myb-related DNA-binding domain which is present in a number of yeast, plant and animal proteins. Its capacity to bind preferentially double-stranded telomeric DNA has been used in numerous studies to search for candidate telomeric proteins in various organisms, including plants. Here we provide an overvie...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666160724200849
更新日期:2017-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203720666190125095819
更新日期:2019-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920307780363460
更新日期:2007-04-01 00:00:00