Progress in Research on Brain Development and Function of Mice During Weaning.

abstract：:The plasma membrane Ca2+ ATPases (PMCAs) are responsible for the clearance of Ca2+ out of cells after intracellular Ca2+ transients. Cooperating with Na+/Ca2+ exchangers (NCXs) and Ca2+ buffering proteins, PMCAs play an essential role in maintaining the long-term cellular Ca2+ homeostasis. The plasma membrane Ca2+ ATP...

journal_title：Current protein & peptide science

authors： Wu X,Weng L,Zhang J,Liu X,Huang J

更新日期：2018-01-01 00:00:00

abstract：:Here we review the present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea. Based on biochemical and structural studies, these proteins were originally assigned a role in the structural organization of chromatin; Sac10...

journal_title：Current protein & peptide science

authors： Xuan J,Feng Y

更新日期：2012-05-01 00:00:00

abstract：:Adipose tissue is not only a tissue where energy is stored but is also involved in regulating several body functions such as appetite and energy expenditure via its endocrine activity. Moreover, it thereby modulates complex processes like reproduction, inflammation and immune response. The products secreted from adipo...

journal_title：Current protein & peptide science

authors： Sauerwein H,Bendixen E,Restelli L,Ceciliani F

更新日期：2014-03-01 00:00:00

abstract：:The biotin carboxylase family is comprised of a group of enzymes that utilize a covalently bound prosthetic group, biotin, as a cofactor. These enzymes, which include acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranoyl-CoA carboxylase, oxaloacetate decarbox...

journal_title：Current protein & peptide science

authors： Jitrapakdee S,Wallace JC

更新日期：2003-06-01 00:00:00

abstract：:For several decades the specificity of proteases has been presented as an active site divided into subsites, using the nomenclature of Schechter & Berger from 1967 (S1, S2... for subsites of the active site; P1, P2... for residues of the substrate occupying the corresponding subsites). At early stages of the research ...

journal_title：Current protein & peptide science

authors： Schechter I

更新日期：2005-12-01 00:00:00

abstract：:Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is implicated as a major etiologic agent of adult periodontal disease. This bacterium is asaccharolytic and possesses strong potency for proteolysis. It produces a novel class of cysteine proteinases, termed gingipains, in the cell-associated and sec...

journal_title：Current protein & peptide science

authors： Kadowaki T,Yamamoto K

更新日期：2003-12-01 00:00:00

abstract：:Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-cysteinylglycine and the predominant intracellular antioxidant in many organisms including humans. GSH and associated enzymes are controlled by a transcription factor-nuclear factor-2 related erythroid factor-2 (Nrf2). In cellular milieu, GSH p...

journal_title：Current protein & peptide science

authors： Narayanankutty A,Job JT,Narayanankutty V

更新日期：2019-01-01 00:00:00

abstract：:In this work, we present an extensive analysis of protein contact network topology applied to a wide data set. We extended the concept of degree distribution to graphlets, describing local connectivity patterns. We compared results to those derived from artificial networks of the same size (number of nodes), reproduci...

journal_title：Current protein & peptide science

authors： Santoni D,Paci P,Di Paola L,Giuliani A

更新日期：2016-01-01 00:00:00

abstract：:Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic c...

journal_title：Current protein & peptide science

authors： Chen H,Liu C,Cheng C,Zheng L,Huang K

更新日期：2018-01-01 00:00:00

abstract：:Natural products serve as a main resource for drug discovery. The ubiquitin-proteasome system (UPS) is one of the primary intracellular protein degradation systems, which is responsible for the degradation of most short-lived, mis-folded and aged proteins. The proteasome is a validated target for cancer treatment, sin...

journal_title：Current protein & peptide science

authors： Wang H,Yang Q,Dou QP,Yang H

更新日期：2018-02-13 00:00:00

abstract：:We compare the DNA-interactive properties of bacteriophage T4 gene 32 protein (gp32) with those of crotamine, a component of the venom of the South American rattlesnake. Gene 32 protein is a classical single-stranded DNA binding protein that has served as a model for this class of proteins. We discuss its biological f...

journal_title：Current protein & peptide science

authors： Karpel RL

更新日期：2015-01-01 00:00:00

abstract：:MEP (mercapto-ethyl-pyridine) HyperCel is one of the hydrophobic charge induction chromatography (HCIC) resins. Under normal operation, proteins are bound to the MEP resin at neutral pH, at which MEP is not charged, mostly via hydrophobic interaction. MEP has a pyridine group, whose pK is 4.8, and hence is positively ...

journal_title：Current protein & peptide science

authors： Arakawa T,Tokunaga M,Maruyama T,Shiraki K

更新日期：2019-01-01 00:00:00

abstract：:The lipid bilayer of the plasma membrane is a selective impermeable barrier for the internalization of most macromolecules. Cell penetrating peptides (CPPs) could cross the plasma membrane barrier to deliver various molecules into cells and are considered as a promising tool to deliver macromolecular drugs. However, t...

journal_title：Current protein & peptide science

authors： Zhu P,Jin L

更新日期：2018-01-01 00:00:00

abstract：:While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now recognized, deciphering their molecular mode of action at the structural level still remains highly challenging and requires a combination of many biophysical approaches. Among them, small angle X-ray scattering (SAXS) has been...

journal_title：Current protein & peptide science

authors： Receveur-Brechot V,Durand D

更新日期：2012-02-01 00:00:00

abstract：:Knowledge of the existence and structure of intermediates on the reaction pathway is necessary before specific details of the mechanism may be successfully resolved. However, enzymatic catalysis is an extremely fast process. This rapidity of enzyme-catalyzed reactions and the short life times of intermediates represen...

journal_title：Current protein & peptide science

authors： Dunn BM,Uversky VN

更新日期：2009-10-01 00:00:00

abstract：:Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...

journal_title：Current protein & peptide science

authors： Wong JH,Xia L,Ng TB

更新日期：2007-10-01 00:00:00

abstract：:Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing "treasure trove" o...

journal_title：Current protein & peptide science

authors： Wilson DN,Blaha G,Connell SR,Ivanov PV,Jenke H,Stelzl U,Teraoka Y,Nierhaus KH

更新日期：2002-02-01 00:00:00

abstract：:The majority of tRNA studies has focused on tRNA molecules as pivotal player in the fundamental process of protein synthesis. Mounting studies have unveiled further functions for tRNA beyond protein synthesis, including non-ribosomal amino acid transfer, and regulation of targeted proteolysis. Post-translational N-ter...

journal_title：Current protein & peptide science

authors： Eldeeb MA,Ragheb MA

更新日期：2018-01-01 00:00:00

abstract：:The needs for purified nucleic acids for preparative and analytical applications have increased constantly, demanding for the development of new and more efficient methods for their recovery and isolation. DNA molecules harbour some intrinsic chemical properties that render them suitable for chromatographic separation...

journal_title：Current protein & peptide science

authors： Matos T,Bülow L

更新日期：2019-01-01 00:00:00

abstract：:The complement system is a major effector arm of the immune defense contributing to the destruction of invading pathogens. There are three possible routes of complement cascade activation: the classical, the alternative and the lectin pathways. The activation of the classical and lectin pathways is initiated by supram...

journal_title：Current protein & peptide science

authors： Gál P,Ambrus G

更新日期：2001-03-01 00:00:00

abstract：:Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...

journal_title：Current protein & peptide science

authors： Dürvanger Z,Harmat V

更新日期：2019-01-01 00:00:00

abstract：:Cardiomyocytes are best known for their spontaneous beating activity, large cell size, and low regenerative capacity during adulthood. The mechanical activity of cardiomyocytes depends on a sophisticated contractile apparatus comprised of sarcomeres whose rhythmic contraction relies on Ca(2+) transients with a high le...

journal_title：Current protein & peptide science

authors： Christians ES,Mustafi SB,Benjamin IJ

更新日期：2014-05-01 00:00:00

abstract：:Serine proteases and their natural inhibitors have long been served as excellent models for studying (primary, secondary and tertiary) structure - activity relationships of biologically interacting proteins. As protein flexibility has been accepted as a "fourth dimension" of the protein structure, its contribution to ...

journal_title：Current protein & peptide science

authors： Gráf L,Molnár T,Kardos J,Gáspári Z,Katona G

更新日期：2015-01-01 00:00:00

abstract：:SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...

journal_title：Current protein & peptide science

authors： Korsinczky ML,Schirra HJ,Craik DJ

更新日期：2004-10-01 00:00:00

abstract：:Carnosine (β-alanyl-L-histidine) and its methylated derivatives: anserine (β-alanyl-Nπ- methyl-L-histidine) and balenine (β-alanyl-Nτ-methyl-L-histidine) are abundant constituents of excitable tissues of vertebrates. While carnosine and anserine are present at high concentrations and in variable proportions in skeleta...

journal_title：Current protein & peptide science

authors： Kwiatkowski S,Kiersztan A,Drozak J

更新日期：2018-01-01 00:00:00

abstract：:The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensivel...

journal_title：Current protein & peptide science

authors： Liu Y,Liu S,Zhang X,Liang X,Zahid KR,Liu K,Liu J,Deng L,Yang J,Qi C

更新日期：2016-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are effector molecules of innate immune systems found in different groups of organisms, including microorganisms, plants, insects, amphibians and humans. These peptides exhibit several structural motifs but the most abundant AMPs assume an amphipathic alpha-helical structure. The alpha-he...

journal_title：Current protein & peptide science

authors： Castro MS,Cilli EM,Fontes W

更新日期：2006-12-01 00:00:00

abstract：:Host cell entry by influenza and other enveloped viruses is well characterized, however, the manner in which non-enveloped viruses deliver their genome across host cell membranes in the absence of membrane fusion remains unresolved. The discovery of short, membrane altering, amphipathic or hydrophobic sequences in sev...

journal_title：Current protein & peptide science

authors： Banerjee M,Johnson JE

更新日期：2008-02-01 00:00:00

abstract：:A complete understanding of the relationships between protein structure and stability remains an open problem. Much of our insight comes from laborious experimental analyses that perturb structure via directed mutation. The glycolytic enzyme lysozyme is among the most well characterized proteins under this paradigm, d...

journal_title：Current protein & peptide science

authors： Verma D,Jacobs DJ,Livesay DR

更新日期：2010-11-01 00:00:00

abstract：:Covalent conjugation of the ubiquitin tag to cellular proteins plays a central role in a number of processes, the most notable among them being degradation by the 26S proteasome. A fundamental property of this process is that ubiquitination, in contrast to subsequent degradation, is reversible due to a number of deubi...

journal_title：Current protein & peptide science

authors： Guterman A,Glickman MH

更新日期：2004-06-01 00:00:00