Abstract:
:Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural basis of the regulation functions of CaM, the investigation of complexes of CaM and its targets is essential. In this minireview we give an outline of the different types of CaM - peptide complexes with 3D structure determined, also providing an overview of recently determined structures. We discuss factors defining the orientations of peptides within the complexes, as well as roles of anchoring residues. The emphasis is on complexes where multiple binding modes were found.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Dürvanger Z,Harmat Vdoi
10.2174/1389203720666190925101937subject
Has Abstractpub_date
2019-01-01 00:00:00pages
1102-1111issue
11eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-100987journal_volume
20pub_type
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