The biotin enzyme family: conserved structural motifs and domain rearrangements.

abstract：:The number of protein folds in nature is limited, thus is not surprising that proteins with the same fold are able to exert different functions. The cysteine protease inhibitors that adopt an immunoglobulin- like fold (Ig-ICPs) are inhibitors encoded in bacteria and protozoan parasites. Structural studies indicate tha...

journal_title：Current protein & peptide science

authors： Jimenez-Sandoval P,Lopez-Castillo LM,Trasviña-Arenas CH,Brieba LG

更新日期：2017-01-01 00:00:00

abstract：:In this work, we present an extensive analysis of protein contact network topology applied to a wide data set. We extended the concept of degree distribution to graphlets, describing local connectivity patterns. We compared results to those derived from artificial networks of the same size (number of nodes), reproduci...

journal_title：Current protein & peptide science

authors： Santoni D,Paci P,Di Paola L,Giuliani A

更新日期：2016-01-01 00:00:00

abstract：:Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic c...

journal_title：Current protein & peptide science

authors： Chen H,Liu C,Cheng C,Zheng L,Huang K

更新日期：2018-01-01 00:00:00

abstract：:Host cell entry by influenza and other enveloped viruses is well characterized, however, the manner in which non-enveloped viruses deliver their genome across host cell membranes in the absence of membrane fusion remains unresolved. The discovery of short, membrane altering, amphipathic or hydrophobic sequences in sev...

journal_title：Current protein & peptide science

authors： Banerjee M,Johnson JE

更新日期：2008-02-01 00:00:00

abstract：:Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myos...

journal_title：Current protein & peptide science

authors： Zheng W,Brooks BR,Thirumalai D

更新日期：2009-04-01 00:00:00

abstract：:A complete understanding of the relationships between protein structure and stability remains an open problem. Much of our insight comes from laborious experimental analyses that perturb structure via directed mutation. The glycolytic enzyme lysozyme is among the most well characterized proteins under this paradigm, d...

journal_title：Current protein & peptide science

authors： Verma D,Jacobs DJ,Livesay DR

更新日期：2010-11-01 00:00:00

abstract：:Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...

journal_title：Current protein & peptide science

authors： Albar AH,Almehdar HA,Uversky VN,Redwan EM

更新日期：2014-01-01 00:00:00

abstract：:Allergen-specific Immunotherapy (AIT), through repetitive subcutaneous or sublingual administrations of allergen extracts, represents up to now the unique treatment against allergic sensitizations. However, the clinical efficacy of AIT can be largely dependent on the quality of natural allergen extracts. Moreover, the...

journal_title：Current protein & peptide science

authors： Jacquet A

更新日期：2020-01-01 00:00:00

abstract：:Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of bioge...

journal_title：Current protein & peptide science

authors： Fan P,Song P,Li L,Huang C,Chen J,Yang W,Qiao S,Wu G,Zhang G,Ma X

更新日期：2017-01-01 00:00:00

abstract：:Serine proteinases fulfill and facilitate a broad spectrum of biological processes. They are held in check by different specific inhibitors. This delicate balance can be disturbed by genetic defects or exogenous influences and has been shown as the underlying or promoting cause for a large number of different diseases...

journal_title：Current protein & peptide science

authors： Mägert HJ,Drögemüller K,Raghunath M

更新日期：2005-06-01 00:00:00

abstract：:Telobox is a Myb-related DNA-binding domain which is present in a number of yeast, plant and animal proteins. Its capacity to bind preferentially double-stranded telomeric DNA has been used in numerous studies to search for candidate telomeric proteins in various organisms, including plants. Here we provide an overvie...

journal_title：Current protein & peptide science

authors： Peška V,Schrumpfová PP,Fajkus J

更新日期：2011-03-01 00:00:00

abstract：:Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...

journal_title：Current protein & peptide science

authors： Turra D,Lorito M

更新日期：2011-08-01 00:00:00

abstract：:Natural products serve as a main resource for drug discovery. The ubiquitin-proteasome system (UPS) is one of the primary intracellular protein degradation systems, which is responsible for the degradation of most short-lived, mis-folded and aged proteins. The proteasome is a validated target for cancer treatment, sin...

journal_title：Current protein & peptide science

authors： Wang H,Yang Q,Dou QP,Yang H

更新日期：2018-02-13 00:00:00

abstract：:Cardiovascular (CV) diseases are caused by vascular dysfunction. The enhanced sensitivity to vasoconstrictors, reduced endothelium-derived vasodilators nitric oxide (NO) and prostacyclin (PGI2), and endothelium-derived hyperpolarization (EDH) indicate CV dysfunction. In recent years, recombinant human relaxin, known a...

journal_title：Current protein & peptide science

authors： Murtaza G,Siddiqui A,Hussain I

更新日期：2018-01-01 00:00:00

abstract：:Naturally occurring protease inhibitors (PI) of the Bowman-Birk type constitute a major PI family in cereal and legume seeds. The family name is derived from the names of the two investigators who characterised the first inhibitor of this type, the Bowman-Birk inhibitor from soybean (BBI). These proteins have the capa...

journal_title：Current protein & peptide science

authors： Clementea A,Domoney C

更新日期：2006-06-01 00:00:00

abstract：:There has been a tremendous increase in the number of approved drugs derived from recombinant proteins; however, their development as potential drugs has been hampered by their instability that causes difficulty to formulate them as therapeutic agents. It has been shown that the reactivity of thiol and disulfide funct...

journal_title：Current protein & peptide science

authors： Trivedi MV,Laurence JS,Siahaan TJ

更新日期：2009-12-01 00:00:00

abstract：:A growing body of work demonstrates the importance of post-transcriptional control, in particular translation initiation, in the overall regulation of gene expression. Here we focus on the contribution of regulatory elements within the 5' and 3' untranslated regions of mRNA to gene expression in eukaryotic cells inclu...

journal_title：Current protein & peptide science

authors： Pichon X,Wilson LA,Stoneley M,Bastide A,King HA,Somers J,Willis AE

更新日期：2012-06-01 00:00:00

abstract：:Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in the enteroend...

journal_title：Current protein & peptide science

authors： Thulesen J

更新日期：2004-02-01 00:00:00

abstract：:The current lack of complete understanding of the pathogenesis of acute kidney injury (AKI) is a significant barrier to its early diagnosis and treatment. Cell cycle arrest plays an important role in the protection of renal tubular epithelial cells and maladaptive repair following AKI. G1 phase cell arrest serves as a...

journal_title：Current protein & peptide science

authors： Wang WG,Sun WX,Gao BS,Lian X,Zhou HL

更新日期：2017-01-01 00:00:00

abstract：:Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...

journal_title：Current protein & peptide science

authors： Kentsis A,Borden KL

更新日期：2000-07-01 00:00:00

abstract：:This work briefly describes available sensors for cAMP and cGMP. Many sensors are based on derivatization of naturally occurring products such as immunoglobulins, protein kinases, etc. Only a few published works deal with chemosensors, which are built up by "total" chemical synthesis. This field stays opened for combi...

journal_title：Current protein & peptide science

authors： Sebestík J,Hlavácek J,Stibor I

更新日期：2005-04-01 00:00:00

abstract：:Membrane proteins play important roles in signal transduction across the cell membrane. Structural information for the membrane proteins is still limited due to many technical challenges. Membrane proteins containing a single α- helical transmembrane (TM) domain are very important in several pathways. Solution NMR spe...

journal_title：Current protein & peptide science

authors： Gayen S,Li Q,Kang C

更新日期：2012-09-01 00:00:00

abstract：:STATs promote fundamental cellular processes, marking them as convergence points of many oncogenic and inflammatory pathways. Therefore, aberrant activation of STAT signaling is implicated in a plethora of human diseases, like cancer, inflammation and auto-immunity. Identification of STAT-specific inhibitors is the to...

journal_title：Current protein & peptide science

authors： Szelag M,Wesoly J,Bluyssen HA

更新日期：2016-01-01 00:00:00

abstract：:Phytohormone crosstalk is crucial for plant defenses against pathogens and insects in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles. These low molecular mass signals critically trigger and modulate plant resistance against biotrophic as well as necrotrophic pathogens through a complex...

journal_title：Current protein & peptide science

authors： Yang YX,Ahammed GJ,Wu C,Fan SY,Zhou YH

更新日期：2015-01-01 00:00:00

abstract：:Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-cysteinylglycine and the predominant intracellular antioxidant in many organisms including humans. GSH and associated enzymes are controlled by a transcription factor-nuclear factor-2 related erythroid factor-2 (Nrf2). In cellular milieu, GSH p...

journal_title：Current protein & peptide science

authors： Narayanankutty A,Job JT,Narayanankutty V

更新日期：2019-01-01 00:00:00

abstract：:Glycoconjugates comprise a variety of structures, include glycoproteins and glycolipids and are found on the surfaces of animal and plant cells, as well as on the surface of microorganisms. Determination of the structure and the distribution of glycoconjugates on cell surfaces are important for the understanding their...

journal_title：Current protein & peptide science

authors： Naeem A,Saleemuddin M,Khan RH

更新日期：2007-06-01 00:00:00

abstract：:SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...

journal_title：Current protein & peptide science

authors： Korsinczky ML,Schirra HJ,Craik DJ

更新日期：2004-10-01 00:00:00

abstract：:Tribbles homolog 3 (TRIB3) is a mammalian gene that is upregulated in response to several types of cell death-inducing cellular stress. The TRIB3 protein is a pseudokinase, a protein kinase-like scaffold with impaired catalytic activity. However, research has revealed it to be prolific at forming protein- protein inte...

journal_title：Current protein & peptide science

authors： Ord T,Ord T

更新日期：2017-01-01 00:00:00

abstract：:The cytolysin is a novel, two-peptide lytic toxin produced by some strains of Enterococcus faecalis. It is toxic in animal models of enterococcal infection, and associated with acutely terminal outcome in human infection. The cytolysin exerts activity against a broad spectrum of cell types including a wide range of gr...

journal_title：Current protein & peptide science

authors： Cox CR,Coburn PS,Gilmore MS

更新日期：2005-02-01 00:00:00

abstract：:Evidence is accumulating that small open reading frames (sORF, <100 codons) play key roles in many important biological processes. Yet, they are generally ignored in gene annotation despite they are far more abundant than the genes with more than 100 codons. Here, we demonstrate that popular homolog search and codon-i...

journal_title：Current protein & peptide science

authors： Cheng H,Chan WS,Li Z,Wang D,Liu S,Zhou Y

更新日期：2011-09-01 00:00:00