Abstract:
:Phytohormone crosstalk is crucial for plant defenses against pathogens and insects in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles. These low molecular mass signals critically trigger and modulate plant resistance against biotrophic as well as necrotrophic pathogens through a complex signaling network that even involves participation of other hormones. Crosstalk among SA, JA and ET is mediated by different molecular players, considered as integral part of these crosscommunicating signal transduction pathways. Recent progress has revealed that the positive versus negative interactions among those pathways ultimately enable a plant to fine-tune its defense against specific aggressors. On the other hand, pathogens have evolved strategies to manipulate the signaling network to their favour in order to intensify virulence on host plant. Here we review recent advances and current knowledge on the role of classical primary defense hormones SA, JA and ET as well as their synergistic and antagonistic interaction in plant disease and immune responses. Crosstalk with other hormones such as abscisic acid, auxin, brassinosteroids, cytokinins and melatonin is also discussed mainly in plant disease resistance. In addition to our keen focus on hormonal crosstalk, this review also highlights potential implication of positive and negative regulatory interactions for developing an efficient disease management strategy through manipulation of hormone signaling in plant.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Yang YX,Ahammed GJ,Wu C,Fan SY,Zhou YHdoi
10.2174/1389203716666150330141638subject
Has Abstractpub_date
2015-01-01 00:00:00pages
450-61issue
5eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-66243journal_volume
16pub_type
杂志文章,评审abstract::It is now well established that the protein folding reaction proceeds via accumulation of various intermediate states. Osmolytes, besides their role in protein stabilization, have also been shown to possess the ability of inducing tremendous affects on these protein folding intermediates, reshape the folding pathway a...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666150623104330
更新日期:2015-01-01 00:00:00
abstract::Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140919124530
更新日期:2014-01-01 00:00:00
abstract::The absence of uracil from DNA genomes is a consequence of enzyme functions that eliminate intracellular dUTP pools and that purposefully recognize and remove uracil moieties from DNA. These enzymatic functions are dUTP nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UDG), respectively. There are distinct nu...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203013381044
更新日期:2001-12-01 00:00:00
abstract::Secondary structure elements often mediate protein-protein interactions. Despite their low abundance in folded proteins, polyproline II (PPII) and its variant, the triple helix, are frequently involved in protein-protein interactions, likely due to their peculiar propensity to be solvent-exposed. We here review the ro...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920312804871157
更新日期:2012-12-01 00:00:00
abstract::Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functional...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666161213115746
更新日期:2017-01-01 00:00:00
abstract::Knowledge of the existence and structure of intermediates on the reaction pathway is necessary before specific details of the mechanism may be successfully resolved. However, enzymatic catalysis is an extremely fast process. This rapidity of enzyme-catalyzed reactions and the short life times of intermediates represen...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920309789351958
更新日期:2009-10-01 00:00:00
abstract::Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203720666190925101937
更新日期:2019-01-01 00:00:00
abstract::An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203720666190729122614
更新日期:2020-01-01 00:00:00
abstract::Heart failure (HF) is a condition with high mortality worldwide characterized by persistent progression. Myocardial hypertrophy is a dominant feature during the early stage of HF. The development of HF is a complex process related to a series of physiologic and molecular factors. Although the treatment of HF has been ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920312804142084
更新日期:2012-11-01 00:00:00
abstract::Proteasomes are the major nonlysosomal protein degradation machinery in eukaryotic cells and they are largely responsible for the processing of antigens for presentation by the MHC class I pathway. This review concentrates on recent developments in the area of antigen processing. Specialized proteasomes called immunop...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379774
更新日期:2004-06-01 00:00:00
abstract::Prostate cancer is one of the major threats to the man's health. There are several mechanisms of the prostate cancer development characterized by the involvement of various androgen-related and androgen-unrelated factors in prostate cancer pathogenesis and in the metastatic carcinogenesis of prostate. In all these pro...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666161028145848
更新日期:2017-01-01 00:00:00
abstract::Bacteria carry a battery of multidrug transporters, which belong to six families of transporters. Members of at least three families the ATP-Binding Cassette superfamily, the Major Facilitator Superfamily and the Multidrug Endosomal Transporter family have been shown to contribute to multidrug resistance phenotype in ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203023380512
更新日期:2002-10-01 00:00:00
abstract::Staphylococcus aureus is a major cause of infection in humans and animals, causing a wide variety of diseases, from local inflammations to fatal sepsis. The bacterium is commonly multi-drug resistant and thus many front-line antibiotics have been rendered ineffective for treating such infections. Research on murein/pe...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666151102105515
更新日期:2016-01-01 00:00:00
abstract::CD2 (cluster of differentiation 2) is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). Tremendous progress has been achieved in understanding the function of CD2, the mechanism of molecular recognition and protein folding, thus, leading towards the use of t...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203033487063
更新日期:2003-10-01 00:00:00
abstract::In this work, we present an extensive analysis of protein contact network topology applied to a wide data set. We extended the concept of degree distribution to graphlets, describing local connectivity patterns. We compared results to those derived from artificial networks of the same size (number of nodes), reproduci...
journal_title:Current protein & peptide science
pub_type: 杂志文章
doi:10.2174/138920371701151130203441
更新日期:2016-01-01 00:00:00
abstract::SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379594
更新日期:2004-10-01 00:00:00
abstract::NOD Like Receptors (NLRs) are the most abundant cytoplasmic immune receptors in plants and animals and they similarly act sensing pathogen invasion and activating immune response. Despite the fact that plant and mammals NLRs share homology.; with some protein structure differences.; for signalling pathway.; divergent ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666160317142306
更新日期:2017-01-01 00:00:00
abstract::Elevated blood pressure or hypertension is one of the fastest growing health problems worldwide. Although the etiology of essential hypertension has a genetic component, dietary factors play an important role. With the high costs and adverse side-effects associated with synthetic antihypertensive drugs and the awarene...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/13892037113149990036
更新日期:2013-05-01 00:00:00
abstract::Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is implicated as a major etiologic agent of adult periodontal disease. This bacterium is asaccharolytic and possesses strong potency for proteolysis. It produces a novel class of cysteine proteinases, termed gingipains, in the cell-associated and sec...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203033486992
更新日期:2003-12-01 00:00:00
abstract::STATs promote fundamental cellular processes, marking them as convergence points of many oncogenic and inflammatory pathways. Therefore, aberrant activation of STAT signaling is implicated in a plethora of human diseases, like cancer, inflammation and auto-immunity. Identification of STAT-specific inhibitors is the to...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666151102103706
更新日期:2016-01-01 00:00:00
abstract::X-box binding protein 1 (XBP-1) is a key regulator of the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum (ER) stress. Cells contain two protein isoforms of XBP-1, the active isoform (XBP-1S) and the inactive isoform (XBP-1U). Induction of UPR leads to the generation of XBP-1S ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666170911144812
更新日期:2018-01-01 00:00:00
abstract::Photosynthetic organisms and isolated photosystems are of interest for technical applications. In nature, photosynthetic electron transport has to work efficiently in contrasting environments such as shade and full sunlight at noon. Photosynthetic electron transport is regulated on many levels, starting with the energ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140327105143
更新日期:2014-01-01 00:00:00
abstract::Serine proteases and their natural inhibitors have long been served as excellent models for studying (primary, secondary and tertiary) structure - activity relationships of biologically interacting proteins. As protein flexibility has been accepted as a "fourth dimension" of the protein structure, its contribution to ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666150429123733
更新日期:2015-01-01 00:00:00
abstract::Cardiomyocytes are best known for their spontaneous beating activity, large cell size, and low regenerative capacity during adulthood. The mechanical activity of cardiomyocytes depends on a sophisticated contractile apparatus comprised of sarcomeres whose rhythmic contraction relies on Ca(2+) transients with a high le...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140331111518
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Drug-Target Interactions (DTI) play a crucial role in discovering new drug candidates and finding new proteins to target for drug development. Although the number of detected DTI obtained by high-throughput techniques has been increasing, the number of known DTI is still limited. On the other hand, the exper...
journal_title:Current protein & peptide science
pub_type: 杂志文章
doi:10.2174/1389203718666161122103057
更新日期:2018-01-01 00:00:00
abstract::CGRP and adrenomedullin [AM] are peptides that have a number of physiological effects, including vasodilation, through the activation of a shared GPCR, the family B calcitonin receptor-like receptor [CLR]. Specificity to each ligand is conferred through the unusual association of CLR with a single transmembrane access...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/13892037113149990053
更新日期:2013-08-01 00:00:00
abstract::The cytolysin is a novel, two-peptide lytic toxin produced by some strains of Enterococcus faecalis. It is toxic in animal models of enterococcal infection, and associated with acutely terminal outcome in human infection. The cytolysin exerts activity against a broad spectrum of cell types including a wide range of gr...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203053027557
更新日期:2005-02-01 00:00:00
abstract::The plasma membrane Ca2+ ATPases (PMCAs) are responsible for the clearance of Ca2+ out of cells after intracellular Ca2+ transients. Cooperating with Na+/Ca2+ exchangers (NCXs) and Ca2+ buffering proteins, PMCAs play an essential role in maintaining the long-term cellular Ca2+ homeostasis. The plasma membrane Ca2+ ATP...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203719666180416122745
更新日期:2018-01-01 00:00:00
abstract::MEP (mercapto-ethyl-pyridine) HyperCel is one of the hydrophobic charge induction chromatography (HCIC) resins. Under normal operation, proteins are bound to the MEP resin at neutral pH, at which MEP is not charged, mostly via hydrophobic interaction. MEP has a pyridine group, whose pK is 4.8, and hence is positively ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666171117105132
更新日期:2019-01-01 00:00:00
abstract::The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensivel...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666160125115130
更新日期:2016-01-01 00:00:00