NOD-Like Receptors: A Tail from Plants to Mammals Through Invertebrates.

abstract：:Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functional...

journal_title：Current protein & peptide science

authors： Permyakov EA,Uversky VN,Permyakov SE

更新日期：2017-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) represent an emerging class of proteins (or domains) that are characterized by a lack of ordered secondary and tertiary structure. This group of proteins has recently attracted tremendous interest primarily because of a unique feature: they can bind to different targets due to ...

journal_title：Current protein & peptide science

authors： Guo LW,Ruoho AE

更新日期：2008-12-01 00:00:00

abstract：:Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...

journal_title：Current protein & peptide science

authors： Wong JH,Xia L,Ng TB

更新日期：2007-10-01 00:00:00

abstract：:TOYOPEARL particles are cross-linked hydroxylated methacrylic polymers available in different pore and particle sizes. They are conjugated with different ligands to generate ion-exchange, hydrophobic interaction and affinity resins. They have excellent physical and chemical properties. A mixed-mode resin, TOYOPEARL MX...

journal_title：Current protein & peptide science

authors： Arakawa T

更新日期：2019-01-01 00:00:00

abstract：:Peptides act as promising anticancer agents due to their ease of synthesis and modifications, enhanced tumor penetration, and less systemic toxicity. However, only limited success has been achieved so far, as experimental design and synthesis of anticancer peptides (ACPs) are prohibitively costly and time-consuming. F...

journal_title：Current protein & peptide science

authors： Basith S,Manavalan B,Shin TH,Lee DY,Lee G

更新日期：2020-01-01 00:00:00

abstract：:Fungal diseases are severe and have very high morbidity as well as up to 60% mortality for patients diagnosed with invasive fungal infection. In this review, in vitro and in vivo studies provided us with the insight into the role of Candida virulence factors that mediate their success as pathogens, such as: membrane a...

journal_title：Current protein & peptide science

authors： Staniszewska M

更新日期：2020-01-01 00:00:00

abstract：:The bioactive peptides are protein fragments which have a positive impact on the intestinal homeostasis. Intestinal homeostasis depends on the diverse functions of intestinal barrier including the microbiological, physical, chemical and immunological barriers. Defects in intestinal barrier function are associated with...

journal_title：Current protein & peptide science

authors： Ji J,Qu H,Shu D

更新日期：2015-01-01 00:00:00

abstract：:Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages--the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagn...

journal_title：Current protein & peptide science

authors： Singh B,Singh S,Asif AR,Oellerich M,Sharma GL

更新日期：2014-01-01 00:00:00

abstract：:PDZ domains are versatile protein interaction modules with the ability to dimerize and to recognize internal and carboxy-terminal peptide motifs. Their function in mediating the formation of multi-molecular signaling complexes is best understood at neuronal and epithelial membranes. In a screen for interactors that re...

journal_title：Current protein & peptide science

authors： Thomas MK,Tsang SW,Yeung ML,Leung PS,Yao KM

更新日期：2009-02-01 00:00:00

abstract：:The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensivel...

journal_title：Current protein & peptide science

authors： Liu Y,Liu S,Zhang X,Liang X,Zahid KR,Liu K,Liu J,Deng L,Yang J,Qi C

更新日期：2016-01-01 00:00:00

abstract：:While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now recognized, deciphering their molecular mode of action at the structural level still remains highly challenging and requires a combination of many biophysical approaches. Among them, small angle X-ray scattering (SAXS) has been...

journal_title：Current protein & peptide science

authors： Receveur-Brechot V,Durand D

更新日期：2012-02-01 00:00:00

abstract：:In this work, we present an extensive analysis of protein contact network topology applied to a wide data set. We extended the concept of degree distribution to graphlets, describing local connectivity patterns. We compared results to those derived from artificial networks of the same size (number of nodes), reproduci...

journal_title：Current protein & peptide science

authors： Santoni D,Paci P,Di Paola L,Giuliani A

更新日期：2016-01-01 00:00:00

abstract：:Phytohormone crosstalk is crucial for plant defenses against pathogens and insects in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles. These low molecular mass signals critically trigger and modulate plant resistance against biotrophic as well as necrotrophic pathogens through a complex...

journal_title：Current protein & peptide science

authors： Yang YX,Ahammed GJ,Wu C,Fan SY,Zhou YH

更新日期：2015-01-01 00:00:00

abstract：:The family of peptides designated as cathelicidins was identified over a decade ago. Cathelicidins have since gained increasing recognition, both as endogenous antibiotics and as effector molecules of the innate immune system. The human cathelicidin LL-37 is widely expressed in human tissues and plays diverse biologic...

journal_title：Current protein & peptide science

authors： Wong JH,Ye XJ,Ng TB

更新日期：2013-09-01 00:00:00

abstract：:Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in the enteroend...

journal_title：Current protein & peptide science

authors： Thulesen J

更新日期：2004-02-01 00:00:00

abstract：:Prediction of protein domain boundaries is an important step for the prediction of three-dimensional structure. The simple method PDP has been elaborated for prediction of the number and position of domain boundaries in multi-domain proteins by use of amino acid sequence alone. The method uses an optimized scale based...

journal_title：Current protein & peptide science

authors： Dovidchenko NV,Lobanov MY,Galzitskaya OV

更新日期：2007-04-01 00:00:00

abstract：:Here we review the present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea. Based on biochemical and structural studies, these proteins were originally assigned a role in the structural organization of chromatin; Sac10...

journal_title：Current protein & peptide science

authors： Xuan J,Feng Y

更新日期：2012-05-01 00:00:00

abstract：:Skeletal muscle, the main protein reservoir in the body, is a tissue that exhibits high plasticity when exposed to changes. Muscle proteins can be mobilized into free amino acids when skeletal muscle wasting occurs, a process called skeletal muscle atrophy. This wasting is an important systemic or local manifestation ...

journal_title：Current protein & peptide science

authors： Cabello-Verrugio C,Córdova G,Salas JD

更新日期：2012-09-01 00:00:00

abstract：:An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...

journal_title：Current protein & peptide science

authors： Jeon SH

更新日期：2020-01-01 00:00:00

abstract：:Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is implicated as a major etiologic agent of adult periodontal disease. This bacterium is asaccharolytic and possesses strong potency for proteolysis. It produces a novel class of cysteine proteinases, termed gingipains, in the cell-associated and sec...

journal_title：Current protein & peptide science

authors： Kadowaki T,Yamamoto K

更新日期：2003-12-01 00:00:00

abstract：:This review is to summarize three new QSAR (quantitative structure-activity relationship) methods recently developed in our group and their applications for drug design. Based on more solid theoretical models and advanced mathematical techniques, the conventional QSAR technique has been recast in the following three a...

journal_title：Current protein & peptide science

authors： Du QS,Huang RB,Chou KC

更新日期：2008-06-01 00:00:00

abstract：:Hemoglobin (Hb) is the prototypical example of a cooperative protein. Cooperativity of Hb is largely accounted for by the oxygen-linked allosteric interconversion between the T and R states/structures. Allostery is such a powerful explanation of Hb cooperativity that the possibility of cooperative events occurring wit...

journal_title：Current protein & peptide science

authors： Bellelli A

更新日期：2018-01-01 00:00:00

abstract：:Heart failure (HF) is a condition with high mortality worldwide characterized by persistent progression. Myocardial hypertrophy is a dominant feature during the early stage of HF. The development of HF is a complex process related to a series of physiologic and molecular factors. Although the treatment of HF has been ...

journal_title：Current protein & peptide science

authors： Bi Q

更新日期：2012-11-01 00:00:00

abstract：:The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variatio...

journal_title：Current protein & peptide science

authors： Wright LR,Rothbard JB,Wender PA

更新日期：2003-04-01 00:00:00

abstract：:Covalent conjugation of the ubiquitin tag to cellular proteins plays a central role in a number of processes, the most notable among them being degradation by the 26S proteasome. A fundamental property of this process is that ubiquitination, in contrast to subsequent degradation, is reversible due to a number of deubi...

journal_title：Current protein & peptide science

authors： Guterman A,Glickman MH

更新日期：2004-06-01 00:00:00

abstract：:Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...

journal_title：Current protein & peptide science

authors： Turra D,Lorito M

更新日期：2011-08-01 00:00:00

abstract：:In spite of the relevance of the results obtained through the clinical application of chemotherapeutic agents (reverse transcriptase and proteinase inhibitors) that are able to prolong the life span of affected people, acquired immunodeficiency syndrome (AIDS) remains a serious and lethal disease. AIDS is caused by a ...

journal_title：Current protein & peptide science

authors： Di Bello C,Pasquato A,Dettin M

更新日期：2004-08-01 00:00:00

abstract：:Photosynthetic organisms and isolated photosystems are of interest for technical applications. In nature, photosynthetic electron transport has to work efficiently in contrasting environments such as shade and full sunlight at noon. Photosynthetic electron transport is regulated on many levels, starting with the energ...

journal_title：Current protein & peptide science

authors： Roach T,Krieger-Liszkay A

更新日期：2014-01-01 00:00:00

abstract：:Glycoconjugates comprise a variety of structures, include glycoproteins and glycolipids and are found on the surfaces of animal and plant cells, as well as on the surface of microorganisms. Determination of the structure and the distribution of glycoconjugates on cell surfaces are important for the understanding their...

journal_title：Current protein & peptide science

authors： Naeem A,Saleemuddin M,Khan RH

更新日期：2007-06-01 00:00:00

abstract：:ATPases are important molecular machines that convert the chemical energies stored in ATP to mechanical actions within the cell. ATPases are among the most abundant proteins with diverse functions involved in almost every cellular pathway. The well characterised ATPases include the various motor proteins responsible f...

journal_title：Current protein & peptide science

authors： Rappas M,Niwa H,Zhang X

更新日期：2004-04-01 00:00:00