Abstract:
:An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allergens. In particular, candidate allergens of mosquitoes that are well suited to the ecology of mosquitoes that occur mainly in East Asia will be identified and introduced. By doing so, the diagnosis and treatment of patients with severe sensitivity to mosquito allergy will be improved by predicting the characteristics of East Asian mosquito allergy, presenting the future direction of production of recombinant allergens, and understanding the difference between East and West.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Jeon SHdoi
10.2174/1389203720666190729122614subject
Has Abstractpub_date
2020-01-01 00:00:00pages
153-158issue
2eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-100007journal_volume
21pub_type
杂志文章,评审abstract::To defend themselves from attack by pathogens, plants can rely only on their innate defense systems. Defensins are antimicrobial peptides that contribute to plant immunity by displaying a direct cidal activity against various pathogens, some of which are responsible for plant diseases. These determine a significant de...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920310791112101
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abstract::Alpha-fetoprotein (AFP), known largely as a growth-promoting agent, possesses a growth-inhibitory motif recently identified as an occult epitopic segment in the third domain. The present study reviews the multiple biological activities of this AFP-derived peptide segment termed the Growth Inhibitory Peptide (GIP), whi...
journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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abstract::Structural and theoretical analyses of proteins are central to the understanding of complex molecular mechanisms and are fundamental to the drug discovery process. Computational techniques yield useful insights into an ever-wider range of biomolecular systems. Protein three-dimensional structures and molecular functio...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203023380657
更新日期:2002-06-01 00:00:00
abstract::Secondary structure elements often mediate protein-protein interactions. Despite their low abundance in folded proteins, polyproline II (PPII) and its variant, the triple helix, are frequently involved in protein-protein interactions, likely due to their peculiar propensity to be solvent-exposed. We here review the ro...
journal_title:Current protein & peptide science
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abstract::Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functional...
journal_title:Current protein & peptide science
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更新日期:2017-01-01 00:00:00
abstract::The family of peptides designated as cathelicidins was identified over a decade ago. Cathelicidins have since gained increasing recognition, both as endogenous antibiotics and as effector molecules of the innate immune system. The human cathelicidin LL-37 is widely expressed in human tissues and plays diverse biologic...
journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
abstract::SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
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abstract::Antimicrobial peptides (AMPs) are effector molecules of innate immune systems found in different groups of organisms, including microorganisms, plants, insects, amphibians and humans. These peptides exhibit several structural motifs but the most abundant AMPs assume an amphipathic alpha-helical structure. The alpha-he...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920306779025648
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abstract::Intestines are not only major organs for nutrient digestion and absorption, but are also the largest immune organ in pigs. They are essential for maintaining the health and growth of piglets. Fatty acids, including short-chain fatty acids, medium-chain fatty acids, and long-chain polyunsaturated fatty acids, are impor...
journal_title:Current protein & peptide science
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abstract::NOD Like Receptors (NLRs) are the most abundant cytoplasmic immune receptors in plants and animals and they similarly act sensing pathogen invasion and activating immune response. Despite the fact that plant and mammals NLRs share homology.; with some protein structure differences.; for signalling pathway.; divergent ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Intrinsically disordered proteins (IDPs) represent an emerging class of proteins (or domains) that are characterized by a lack of ordered secondary and tertiary structure. This group of proteins has recently attracted tremendous interest primarily because of a unique feature: they can bind to different targets due to ...
journal_title:Current protein & peptide science
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abstract::Changes in protein structure and function, alteration in protein-protein interaction, and significant difference in protein concentration inside the body could play an important role in indicating the pathological evidence of abnormalities before the development of clinical symptoms and act as a critical detection and...
journal_title:Current protein & peptide science
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abstract::Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Rehmanniae Radix Praeparata (RRP) is a popular medicinal herb widely used in traditional Chinese medicine (TCM) to treat CVDs. However, the development of this novel therapeutic product has been stagnant, and its molecular mechanism of action...
journal_title:Current protein & peptide science
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abstract::The High mobility group box 1 (HMGB1) protein is an extremely versatile, highly conserved nuclear protein, with its unique intracellular and extracellular functions mediated by its relatively simple domain structure. Within the nucleus, HMGB1 binds to DNA minor groove in a nonspecific manner and causes bends in the do...
journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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abstract::The bioactive peptides are protein fragments which have a positive impact on the intestinal homeostasis. Intestinal homeostasis depends on the diverse functions of intestinal barrier including the microbiological, physical, chemical and immunological barriers. Defects in intestinal barrier function are associated with...
journal_title:Current protein & peptide science
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abstract::Membrane proteins play important roles in signal transduction across the cell membrane. Structural information for the membrane proteins is still limited due to many technical challenges. Membrane proteins containing a single α- helical transmembrane (TM) domain are very important in several pathways. Solution NMR spe...
journal_title:Current protein & peptide science
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abstract::Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in the enteroend...
journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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更新日期:2019-01-01 00:00:00
abstract::Hemoglobin (Hb) is the prototypical example of a cooperative protein. Cooperativity of Hb is largely accounted for by the oxygen-linked allosteric interconversion between the T and R states/structures. Allostery is such a powerful explanation of Hb cooperativity that the possibility of cooperative events occurring wit...
journal_title:Current protein & peptide science
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更新日期:2018-01-01 00:00:00
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journal_title:Current protein & peptide science
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abstract::Receptor tyrosine kinases (RTKs) are cell surface receptors that transmit extracellular signals to the interior of the cell activating multiple signaling cascades: the binding of specific extracellular ligands activates RTKs which act as a scaffold at plasma membrane level for the recruitment and activation of several...
journal_title:Current protein & peptide science
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更新日期:2013-11-01 00:00:00
abstract::We compare the DNA-interactive properties of bacteriophage T4 gene 32 protein (gp32) with those of crotamine, a component of the venom of the South American rattlesnake. Gene 32 protein is a classical single-stranded DNA binding protein that has served as a model for this class of proteins. We discuss its biological f...
journal_title:Current protein & peptide science
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更新日期:2015-01-01 00:00:00