Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design.

abstract：:Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved m...

journal_title：Current protein & peptide science

authors： Rabbani G,Baig MH,Ahmad K,Choi I

更新日期：2018-01-01 00:00:00

abstract：:The absence of uracil from DNA genomes is a consequence of enzyme functions that eliminate intracellular dUTP pools and that purposefully recognize and remove uracil moieties from DNA. These enzymatic functions are dUTP nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UDG), respectively. There are distinct nu...

journal_title：Current protein & peptide science

authors： Caradonna S,Muller-Weeks S

更新日期：2001-12-01 00:00:00

abstract：:Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli due to infection and cellular stress have identified to play a vital role in the progr...

journal_title：Current protein & peptide science

authors： Sharma I,Behl T,Bungau S,Sachdeva M,Kumar A,Zengin G,Arora S

更新日期：2020-12-08 00:00:00

abstract：:In this work, we present an extensive analysis of protein contact network topology applied to a wide data set. We extended the concept of degree distribution to graphlets, describing local connectivity patterns. We compared results to those derived from artificial networks of the same size (number of nodes), reproduci...

journal_title：Current protein & peptide science

authors： Santoni D,Paci P,Di Paola L,Giuliani A

更新日期：2016-01-01 00:00:00

abstract：:Dietary protein from fermented cottonseed meal (FCSM), widely used in poultry diets in China, had regulating effects on lipid metabolism. To understand the effects of FCSM on lipid metabolism in broilers, we analyzed the biochemical indexes, enzyme activity, hormone level and metabolites in serum responses to FCSM int...

journal_title：Current protein & peptide science

authors： Nie C,Wang Y,Liu Y,Liu J,Ge W,Ma X,Zhang W

更新日期：2020-01-01 00:00:00

abstract：:Phytohormone crosstalk is crucial for plant defenses against pathogens and insects in which salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) play key roles. These low molecular mass signals critically trigger and modulate plant resistance against biotrophic as well as necrotrophic pathogens through a complex...

journal_title：Current protein & peptide science

authors： Yang YX,Ahammed GJ,Wu C,Fan SY,Zhou YH

更新日期：2015-01-01 00:00:00

abstract：:The affinity tags are unique proteins/peptides that are attached at the N- or C-terminus of the recombinant proteins. These tags help in protein purification. Additionally, some affinity tags also serve a dual purpose as solubility enhancers for challenging protein targets. By applying a combinatorial approach, carefu...

journal_title：Current protein & peptide science

authors： Mishra V

更新日期：2020-01-01 00:00:00

abstract：:Hemoglobin (Hb) is the prototypical example of a cooperative protein. Cooperativity of Hb is largely accounted for by the oxygen-linked allosteric interconversion between the T and R states/structures. Allostery is such a powerful explanation of Hb cooperativity that the possibility of cooperative events occurring wit...

journal_title：Current protein & peptide science

authors： Bellelli A

更新日期：2018-01-01 00:00:00

abstract：:Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledg...

journal_title：Current protein & peptide science

authors： Kishan KV

更新日期：2007-08-01 00:00:00

abstract：:Tic, short for 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, is a kind of unnatural α-amino acids. Due to its distinct geometrical conformation and biological activity, the structure of Tic, regarded as the surrogate of proline and the rigid analogue of phenylalanine or tyrosine, has been introduced into many comp...

journal_title：Current protein & peptide science

authors： Zhang Y,Fang H,Xu W

更新日期：2010-12-01 00:00:00

abstract：:The structure and stability of apolipoprotein (apo)A-I, the major apolipoprotein of human plasma high-density lipoproteins (HDL), determine the efficiency of the protein in the process of HDL generation and affect HDL properties in binding and exchanging its constituents, thus playing an essential role in reverse chol...

journal_title：Current protein & peptide science

authors： Dergunov AD,Garaeva EA,Savushkin EV,Litvinov DY

更新日期：2017-01-01 00:00:00

abstract：:Fibroids or myomas involve large proportion of women of reproductive age. The myoma formation starts from the transformation of the myometrium, causing the progressive formation of a pseudocapsule, which is made of compressed muscle fibers. Numerous studies investigated on myoma pseudocapsule anatomy, discovering many...

journal_title：Current protein & peptide science

authors： Tinelli A,Mynbaev OA,Sparic R,Vergara D,Di Tommaso S,Salzet M,Maffia M,Malvasi A

更新日期：2017-01-01 00:00:00

abstract：:For several decades the specificity of proteases has been presented as an active site divided into subsites, using the nomenclature of Schechter & Berger from 1967 (S1, S2... for subsites of the active site; P1, P2... for residues of the substrate occupying the corresponding subsites). At early stages of the research ...

journal_title：Current protein & peptide science

authors： Schechter I

更新日期：2005-12-01 00:00:00

abstract：:Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of bioge...

journal_title：Current protein & peptide science

authors： Fan P,Song P,Li L,Huang C,Chen J,Yang W,Qiao S,Wu G,Zhang G,Ma X

更新日期：2017-01-01 00:00:00

abstract：:Peptides act as promising anticancer agents due to their ease of synthesis and modifications, enhanced tumor penetration, and less systemic toxicity. However, only limited success has been achieved so far, as experimental design and synthesis of anticancer peptides (ACPs) are prohibitively costly and time-consuming. F...

journal_title：Current protein & peptide science

authors： Basith S,Manavalan B,Shin TH,Lee DY,Lee G

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:In the search of bioactive molecules, nature has always been an important source and most of the drugs in clinic are either natural products or derived from natural products. The ocean has played significant role as thousands of molecules and their metabolites with different types of biological activity such...

journal_title：Current protein & peptide science

authors： Negi B,Kumar D,Rawat DS

更新日期：2017-01-01 00:00:00

abstract：:The needs for purified nucleic acids for preparative and analytical applications have increased constantly, demanding for the development of new and more efficient methods for their recovery and isolation. DNA molecules harbour some intrinsic chemical properties that render them suitable for chromatographic separation...

journal_title：Current protein & peptide science

authors： Matos T,Bülow L

更新日期：2019-01-01 00:00:00

abstract：:Here we review the present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea. Based on biochemical and structural studies, these proteins were originally assigned a role in the structural organization of chromatin; Sac10...

journal_title：Current protein & peptide science

authors： Xuan J,Feng Y

更新日期：2012-05-01 00:00:00

abstract：:It is now well established that the protein folding reaction proceeds via accumulation of various intermediate states. Osmolytes, besides their role in protein stabilization, have also been shown to possess the ability of inducing tremendous affects on these protein folding intermediates, reshape the folding pathway a...

journal_title：Current protein & peptide science

authors： Sharma GS,Dar TA,Singh LR

更新日期：2015-01-01 00:00:00

abstract：:PDZ domains are versatile protein interaction modules with the ability to dimerize and to recognize internal and carboxy-terminal peptide motifs. Their function in mediating the formation of multi-molecular signaling complexes is best understood at neuronal and epithelial membranes. In a screen for interactors that re...

journal_title：Current protein & peptide science

authors： Thomas MK,Tsang SW,Yeung ML,Leung PS,Yao KM

更新日期：2009-02-01 00:00:00

abstract：:Heart failure (HF) is a condition with high mortality worldwide characterized by persistent progression. Myocardial hypertrophy is a dominant feature during the early stage of HF. The development of HF is a complex process related to a series of physiologic and molecular factors. Although the treatment of HF has been ...

journal_title：Current protein & peptide science

authors： Bi Q

更新日期：2012-11-01 00:00:00

abstract：:Cell viability depends on the correct folding of the proteins involved in metabolism. Proteins are synthesized on the endoplasmic reticulum and must follow a pathway to a correct, metastable, tridimensional structure. Changes in structure or in environmental conditions can drive an instability of the folding condition...

journal_title：Current protein & peptide science

authors： de la Arada I,Andraka N,Pacios MG,Arrondo JL

更新日期：2011-05-01 00:00:00

abstract：:Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-cysteinylglycine and the predominant intracellular antioxidant in many organisms including humans. GSH and associated enzymes are controlled by a transcription factor-nuclear factor-2 related erythroid factor-2 (Nrf2). In cellular milieu, GSH p...

journal_title：Current protein & peptide science

authors： Narayanankutty A,Job JT,Narayanankutty V

更新日期：2019-01-01 00:00:00

abstract：:ATPases are important molecular machines that convert the chemical energies stored in ATP to mechanical actions within the cell. ATPases are among the most abundant proteins with diverse functions involved in almost every cellular pathway. The well characterised ATPases include the various motor proteins responsible f...

journal_title：Current protein & peptide science

authors： Rappas M,Niwa H,Zhang X

更新日期：2004-04-01 00:00:00

abstract：:The complement system is a major effector arm of the immune defense contributing to the destruction of invading pathogens. There are three possible routes of complement cascade activation: the classical, the alternative and the lectin pathways. The activation of the classical and lectin pathways is initiated by supram...

journal_title：Current protein & peptide science

authors： Gál P,Ambrus G

更新日期：2001-03-01 00:00:00

abstract：:Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic c...

journal_title：Current protein & peptide science

authors： Chen H,Liu C,Cheng C,Zheng L,Huang K

更新日期：2018-01-01 00:00:00

abstract：:Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in the enteroend...

journal_title：Current protein & peptide science

authors： Thulesen J

更新日期：2004-02-01 00:00:00

abstract：:Arginine is widely used in such applications as protein refolding, solubilization of proteins and small molecules, protein and small molecule formulation, column chromatography and viral inactivation as summarized in this review. What makes arginine effective in these applications is largely based on its ability to su...

journal_title：Current protein & peptide science

authors： Arakawa T,Kita Y

更新日期：2014-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Rehmanniae Radix Praeparata (RRP) is a popular medicinal herb widely used in traditional Chinese medicine (TCM) to treat CVDs. However, the development of this novel therapeutic product has been stagnant, and its molecular mechanism of action...

journal_title：Current protein & peptide science

authors： Zhang X,Wang D,Ren X,Atanasov AG,Zeng R,Huang L

更新日期：2019-01-01 00:00:00

abstract：:Alpha-fetoprotein (AFP), known largely as a growth-promoting agent, possesses a growth-inhibitory motif recently identified as an occult epitopic segment in the third domain. The present study reviews the multiple biological activities of this AFP-derived peptide segment termed the Growth Inhibitory Peptide (GIP), whi...

journal_title：Current protein & peptide science

authors： Mizejewskia GJ,Butterstein G

更新日期：2006-02-01 00:00:00