Abstract:
:Tic, short for 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, is a kind of unnatural α-amino acids. Due to its distinct geometrical conformation and biological activity, the structure of Tic, regarded as the surrogate of proline and the rigid analogue of phenylalanine or tyrosine, has been introduced into many compounds, which target diverse enzymes or receptors. The most successful example is that substituting the Tic residue for the proline residue of enalapril led to an approved drug quinapril. In this review, we will summarize the applications and modifications of Tic in peptides and peptidomimetics design and discovery, and hope to spark medicinal researchers' inspiration in the field of protein and peptide drug design and optimization.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Zhang Y,Fang H,Xu Wdoi
10.2174/138920310794557691subject
Has Abstractpub_date
2010-12-01 00:00:00pages
752-8issue
8eissn
1389-2037issn
1875-5550pii
CPPS-77journal_volume
11pub_type
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