Structure and Function of Fbxo7/PARK15 in Parkinson's Disease.

Abstract:

:Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)- type E3 ubiquitin ligase and also having SCF-independent activities. Mutations within FBXO7 have been found to cause an early-onset Parkinson's disease, and these are found within or near to its functional domains, including its F-box domain (FBD), its proline rich region (PRR), and its ubiquitinlike domain (Ubl). We highlight recent advances in our understanding of Fbxo7 function in Parkinson's disease, with respect to these mutations and where they occur in the Fbxo7 protein. We hypothesize that many of Fbxo7 functions contribute to its role in PD pathogenesis.

journal_name

Curr Protein Pept Sci

authors

Randle SJ,Laman H

doi

10.2174/1389203717666160311121433

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

715-724

issue

7

eissn

1389-2037

issn

1875-5550

pii

CPPS-EPUB-74335

journal_volume

18

pub_type

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