Abstract:
:Serine proteinases fulfill and facilitate a broad spectrum of biological processes. They are held in check by different specific inhibitors. This delicate balance can be disturbed by genetic defects or exogenous influences and has been shown as the underlying or promoting cause for a large number of different diseases. For instance, proteinases are under investigation as drug targets for cancer, infections, neurodegenerative diseases, osteoporosis, inflammatory disorders and many more. Dermatological research has contributed greatly to the appreciation of the complex regulatory network between serine proteinases and serine proteinase inhibitors. In addition, proteolytically trimmed proteinase-activated receptors (PARs) trigger keratinocyte proliferation and differentiation as well as leukocyte attraction and activation. New insights have been gained particularly concerning the progression of inflammatory disorders of the skin. This review summarizes the role of serine proteinase inhibitors in physiology and pathophysiology of the skin.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Mägert HJ,Drögemüller K,Raghunath Mdoi
10.2174/1389203054065374keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
241-54issue
3eissn
1389-2037issn
1875-5550journal_volume
6pub_type
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
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pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
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