Abstract:
:Viscosity of protein solution is one of the most troublesome issues for the high-concentration formulation of protein drugs. In this review, we summarize the practical methods that suppress the viscosity of protein solution using small molecular additives. The small amount of salts decreases the viscosity that results from electrostatic repulsion and attraction. The chaotrope suppresses the hydrophobic attraction and cluster formation, which can lower the solution viscosity. Arginine hydrochloride (ArgHCl) also suppresses the solution viscosity due to the hydrophobic and aromatic interactions between protein molecules. The small molecular additives are the simplest resolution of the high viscosity of protein solution as well as understanding of the primary cause in complex phenomena of protein interactions.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Hong T,Iwashita K,Shiraki Kdoi
10.2174/1389203719666171213114919subject
Has Abstractpub_date
2018-01-01 00:00:00pages
746-758issue
8eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-87379journal_volume
19pub_type
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