Cardioprotective peptides from marine sources.

abstract：:Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Rehmanniae Radix Praeparata (RRP) is a popular medicinal herb widely used in traditional Chinese medicine (TCM) to treat CVDs. However, the development of this novel therapeutic product has been stagnant, and its molecular mechanism of action...

journal_title：Current protein & peptide science

authors： Zhang X,Wang D,Ren X,Atanasov AG,Zeng R,Huang L

更新日期：2019-01-01 00:00:00

abstract：:Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)- type E3 ubiquitin ligase and also having SCF-independent activities. Mutations within FBXO7 have been found to cause an early-onset Parkinson's disease, and these are found within or near to its functional domains, including its F-...

journal_title：Current protein & peptide science

authors： Randle SJ,Laman H

更新日期：2017-01-01 00:00:00

abstract：:Knowledge of the existence and structure of intermediates on the reaction pathway is necessary before specific details of the mechanism may be successfully resolved. However, enzymatic catalysis is an extremely fast process. This rapidity of enzyme-catalyzed reactions and the short life times of intermediates represen...

journal_title：Current protein & peptide science

authors： Dunn BM,Uversky VN

更新日期：2009-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) are type I transmembrane signaling molecules that are expressed in cells of the innate immune system. In these cells, TLRs function as pattern recognition receptors (PRR) that recognize specific molecular patterns derived from microorganisms. Upon activation, TLRs trigger a cascade of intrac...

journal_title：Current protein & peptide science

authors： Lee H,Lee S,Cho IH,Lee SJ

更新日期：2013-02-01 00:00:00

abstract：:Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...

journal_title：Current protein & peptide science

authors： Dürvanger Z,Harmat V

更新日期：2019-01-01 00:00:00

abstract：:Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...

journal_title：Current protein & peptide science

authors： Albar AH,Almehdar HA,Uversky VN,Redwan EM

更新日期：2014-01-01 00:00:00

abstract：:Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing "treasure trove" o...

journal_title：Current protein & peptide science

authors： Wilson DN,Blaha G,Connell SR,Ivanov PV,Jenke H,Stelzl U,Teraoka Y,Nierhaus KH

更新日期：2002-02-01 00:00:00

abstract：:Covalent conjugation of the ubiquitin tag to cellular proteins plays a central role in a number of processes, the most notable among them being degradation by the 26S proteasome. A fundamental property of this process is that ubiquitination, in contrast to subsequent degradation, is reversible due to a number of deubi...

journal_title：Current protein & peptide science

authors： Guterman A,Glickman MH

更新日期：2004-06-01 00:00:00

abstract：:Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...

journal_title：Current protein & peptide science

authors： Kentsis A,Borden KL

更新日期：2000-07-01 00:00:00

abstract：:Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive thera...

journal_title：Current protein & peptide science

authors： Lyu C,Fang F,Li B

更新日期：2019-01-01 00:00:00

abstract：:Allergen-specific Immunotherapy (AIT), through repetitive subcutaneous or sublingual administrations of allergen extracts, represents up to now the unique treatment against allergic sensitizations. However, the clinical efficacy of AIT can be largely dependent on the quality of natural allergen extracts. Moreover, the...

journal_title：Current protein & peptide science

authors： Jacquet A

更新日期：2020-01-01 00:00:00

abstract：:Adipose tissue is not only a tissue where energy is stored but is also involved in regulating several body functions such as appetite and energy expenditure via its endocrine activity. Moreover, it thereby modulates complex processes like reproduction, inflammation and immune response. The products secreted from adipo...

journal_title：Current protein & peptide science

authors： Sauerwein H,Bendixen E,Restelli L,Ceciliani F

更新日期：2014-03-01 00:00:00

abstract：:Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledg...

journal_title：Current protein & peptide science

authors： Kishan KV

更新日期：2007-08-01 00:00:00

abstract：:Skeletal muscle, the main protein reservoir in the body, is a tissue that exhibits high plasticity when exposed to changes. Muscle proteins can be mobilized into free amino acids when skeletal muscle wasting occurs, a process called skeletal muscle atrophy. This wasting is an important systemic or local manifestation ...

journal_title：Current protein & peptide science

authors： Cabello-Verrugio C,Córdova G,Salas JD

更新日期：2012-09-01 00:00:00

abstract：:Fibroids or myomas involve large proportion of women of reproductive age. The myoma formation starts from the transformation of the myometrium, causing the progressive formation of a pseudocapsule, which is made of compressed muscle fibers. Numerous studies investigated on myoma pseudocapsule anatomy, discovering many...

journal_title：Current protein & peptide science

authors： Tinelli A,Mynbaev OA,Sparic R,Vergara D,Di Tommaso S,Salzet M,Maffia M,Malvasi A

更新日期：2017-01-01 00:00:00

abstract：:Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved m...

journal_title：Current protein & peptide science

authors： Rabbani G,Baig MH,Ahmad K,Choi I

更新日期：2018-01-01 00:00:00

abstract：:Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages--the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagn...

journal_title：Current protein & peptide science

authors： Singh B,Singh S,Asif AR,Oellerich M,Sharma GL

更新日期：2014-01-01 00:00:00

abstract：:Identifying the interactions between drugs and target proteins is a key step in drug discovery. This not only aids to understand the disease mechanism, but also helps to identify unexpected therapeutic activity or adverse side effects of drugs. Hence, drug-target interaction prediction becomes an essential tool in the...

journal_title：Current protein & peptide science

authors： Anusuya S,Kesherwani M,Priya KV,Vimala A,Shanmugam G,Velmurugan D,Gromiha MM

更新日期：2018-01-01 00:00:00

abstract：:TOYOPEARL particles are cross-linked hydroxylated methacrylic polymers available in different pore and particle sizes. They are conjugated with different ligands to generate ion-exchange, hydrophobic interaction and affinity resins. They have excellent physical and chemical properties. A mixed-mode resin, TOYOPEARL MX...

journal_title：Current protein & peptide science

authors： Arakawa T

更新日期：2019-01-01 00:00:00

abstract：:It is now well established that the protein folding reaction proceeds via accumulation of various intermediate states. Osmolytes, besides their role in protein stabilization, have also been shown to possess the ability of inducing tremendous affects on these protein folding intermediates, reshape the folding pathway a...

journal_title：Current protein & peptide science

authors： Sharma GS,Dar TA,Singh LR

更新日期：2015-01-01 00:00:00

abstract：:Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myos...

journal_title：Current protein & peptide science

authors： Zheng W,Brooks BR,Thirumalai D

更新日期：2009-04-01 00:00:00

abstract：:An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...

journal_title：Current protein & peptide science

authors： Jeon SH

更新日期：2020-01-01 00:00:00

abstract：:Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-cysteinylglycine and the predominant intracellular antioxidant in many organisms including humans. GSH and associated enzymes are controlled by a transcription factor-nuclear factor-2 related erythroid factor-2 (Nrf2). In cellular milieu, GSH p...

journal_title：Current protein & peptide science

authors： Narayanankutty A,Job JT,Narayanankutty V

更新日期：2019-01-01 00:00:00

abstract：:The interactions of ligands with biomacromolecules play a fundamental role in almost all bioprocesses occuring in living organisms. The binding of ligands can cause the conformational changes of biomacromolecules, possibly affecting their physiological functions. The interactions of ligands with biomacromolecules are ...

journal_title：Current protein & peptide science

authors： Zhang W,Pan L,Wang H,Lv X,Ding K

更新日期：2017-01-01 00:00:00

abstract：:In this work, we present an extensive analysis of protein contact network topology applied to a wide data set. We extended the concept of degree distribution to graphlets, describing local connectivity patterns. We compared results to those derived from artificial networks of the same size (number of nodes), reproduci...

journal_title：Current protein & peptide science

authors： Santoni D,Paci P,Di Paola L,Giuliani A

更新日期：2016-01-01 00:00:00

abstract：:Cell viability depends on the correct folding of the proteins involved in metabolism. Proteins are synthesized on the endoplasmic reticulum and must follow a pathway to a correct, metastable, tridimensional structure. Changes in structure or in environmental conditions can drive an instability of the folding condition...

journal_title：Current protein & peptide science

authors： de la Arada I,Andraka N,Pacios MG,Arrondo JL

更新日期：2011-05-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are effector molecules of innate immune systems found in different groups of organisms, including microorganisms, plants, insects, amphibians and humans. These peptides exhibit several structural motifs but the most abundant AMPs assume an amphipathic alpha-helical structure. The alpha-he...

journal_title：Current protein & peptide science

authors： Castro MS,Cilli EM,Fontes W

更新日期：2006-12-01 00:00:00

abstract：:The family of peptides designated as cathelicidins was identified over a decade ago. Cathelicidins have since gained increasing recognition, both as endogenous antibiotics and as effector molecules of the innate immune system. The human cathelicidin LL-37 is widely expressed in human tissues and plays diverse biologic...

journal_title：Current protein & peptide science

authors： Wong JH,Ye XJ,Ng TB

更新日期：2013-09-01 00:00:00

abstract：:Many naturally occurring bioactive peptides bind to biological membranes. Studying and elucidating the mode of interaction is often an essential step to understand their molecular and biological functions. To obtain the complete orientation and immersion depth of such compounds in the membrane or a membrane-mimetic sy...

journal_title：Current protein & peptide science

authors： Hohlweg W,Kosol S,Zangger K

更新日期：2012-05-01 00:00:00

abstract：:This review is to summarize three new QSAR (quantitative structure-activity relationship) methods recently developed in our group and their applications for drug design. Based on more solid theoretical models and advanced mathematical techniques, the conventional QSAR technique has been recast in the following three a...

journal_title：Current protein & peptide science

authors： Du QS,Huang RB,Chou KC

更新日期：2008-06-01 00:00:00