Abstract:
BACKGROUND:In the search of bioactive molecules, nature has always been an important source and most of the drugs in clinic are either natural products or derived from natural products. The ocean has played significant role as thousands of molecules and their metabolites with different types of biological activity such as antimicrobial, anti-inflammatory, anti-malarial, antioxidant, anti HIV and anticancer activity have been isolated from marine organisms. In particular, marine peptides have attracted much attention due to their high specificity against cancer cell lines that may be attributed to the various unusual amino acid residues and their sequences in the peptide chain. This review aims to identify the various anticancer agents isolated from the marine system and their anticancer potential. METHOD:We did literature search for the anticancer peptides isolated from the different types of microorganism found in the marine system. Total one eighty eight papers were reviewed concisely and most of the important information from these papers were extracted and kept in the present manuscript. RESULTS:This review gives details about the isolation, anticancer potential and mechanism of action of the anticancer peptides of the marine origin. Many of these molecules such as aplidine, dolastatin 10, didemnin B, kahalalide F, elisidepsin (PM02734) are in clinical trials for the treatment of various cancers. CONCLUSION:With the interdisciplinary and collaborative research and technical advancements we can search more promising and affordable anticancer drugs in future.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Negi B,Kumar D,Rawat DSdoi
10.2174/1389203717666160724200849subject
Has Abstractpub_date
2017-01-01 00:00:00pages
885-904issue
9eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-77284journal_volume
18pub_type
杂志文章,评审abstract::The absence of uracil from DNA genomes is a consequence of enzyme functions that eliminate intracellular dUTP pools and that purposefully recognize and remove uracil moieties from DNA. These enzymatic functions are dUTP nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UDG), respectively. There are distinct nu...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203013381044
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abstract::Toll-like receptors (TLRs) are type I transmembrane signaling molecules that are expressed in cells of the innate immune system. In these cells, TLRs function as pattern recognition receptors (PRR) that recognize specific molecular patterns derived from microorganisms. Upon activation, TLRs trigger a cascade of intrac...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203711314010006
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abstract::Pathogenic aggregation is closely associated with various protein misfolding diseases such as type 2 diabetes mellitus and Alzheimer's disease. Amyloidogenic proteins that have a propensity to assemble into amyloid oligomers and fibrils form the aggregates. The tumor suppressor p53, a transcription factor that regulat...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:
更新日期:2015-01-01 00:00:00
abstract::The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of pro...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920308785915245
更新日期:2008-10-01 00:00:00
abstract::This work briefly describes available sensors for cAMP and cGMP. Many sensors are based on derivatization of naturally occurring products such as immunoglobulins, protein kinases, etc. Only a few published works deal with chemosensors, which are built up by "total" chemical synthesis. This field stays opened for combi...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203053545408
更新日期:2005-04-01 00:00:00
abstract::Knowledge of the existence and structure of intermediates on the reaction pathway is necessary before specific details of the mechanism may be successfully resolved. However, enzymatic catalysis is an extremely fast process. This rapidity of enzyme-catalyzed reactions and the short life times of intermediates represen...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920309789351958
更新日期:2009-10-01 00:00:00
abstract::There has been a tremendous increase in the number of approved drugs derived from recombinant proteins; however, their development as potential drugs has been hampered by their instability that causes difficulty to formulate them as therapeutic agents. It has been shown that the reactivity of thiol and disulfide funct...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920309789630534
更新日期:2009-12-01 00:00:00
abstract::Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myos...
journal_title:Current protein & peptide science
pub_type: 杂志文章
doi:10.2174/138920309787847608
更新日期:2009-04-01 00:00:00
abstract::Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920307782411446
更新日期:2007-10-01 00:00:00
abstract::Natural products serve as a main resource for drug discovery. The ubiquitin-proteasome system (UPS) is one of the primary intracellular protein degradation systems, which is responsible for the degradation of most short-lived, mis-folded and aged proteins. The proteasome is a validated target for cancer treatment, sin...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666170111121856
更新日期:2018-02-13 00:00:00
abstract::Cardiovascular (CV) diseases are caused by vascular dysfunction. The enhanced sensitivity to vasoconstrictors, reduced endothelium-derived vasodilators nitric oxide (NO) and prostacyclin (PGI2), and endothelium-derived hyperpolarization (EDH) indicate CV dysfunction. In recent years, recombinant human relaxin, known a...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203719666180709103020
更新日期:2018-01-01 00:00:00
abstract::The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variatio...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203033487252
更新日期:2003-04-01 00:00:00
abstract::The aggregation of proteins or their digested fragments through β-sheet structures has a great significance because it leads to neurodegenerative diseases, which are a problem of the aging societies of the developed countries. Short peptides are typically used as models to study the formation of specific structures. H...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666170516111601
更新日期:2017-01-01 00:00:00
abstract::It is now well established that the protein folding reaction proceeds via accumulation of various intermediate states. Osmolytes, besides their role in protein stabilization, have also been shown to possess the ability of inducing tremendous affects on these protein folding intermediates, reshape the folding pathway a...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666150623104330
更新日期:2015-01-01 00:00:00
abstract::The Mastermind-like (MAML) proteins are transcriptional coactivators for Notch signaling, an evolutionarily conserved pathway that plays several key roles in development and in human disease. The MAML family contains MAML1, MAML2, and MAML3. More recently, MAML1 has been shown to function as a coactivator for the tumo...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920309789630543
更新日期:2009-12-01 00:00:00
abstract::PDZ domains are versatile protein interaction modules with the ability to dimerize and to recognize internal and carboxy-terminal peptide motifs. Their function in mediating the formation of multi-molecular signaling complexes is best understood at neuronal and epithelial membranes. In a screen for interactors that re...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920309787315248
更新日期:2009-02-01 00:00:00
abstract::CD2 (cluster of differentiation 2) is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). Tremendous progress has been achieved in understanding the function of CD2, the mechanism of molecular recognition and protein folding, thus, leading towards the use of t...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203033487063
更新日期:2003-10-01 00:00:00
abstract::Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140919124530
更新日期:2014-01-01 00:00:00
abstract::Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920311796391151
更新日期:2011-08-01 00:00:00
abstract::Carnosine (β-alanyl-L-histidine) and its methylated derivatives: anserine (β-alanyl-Nπ- methyl-L-histidine) and balenine (β-alanyl-Nτ-methyl-L-histidine) are abundant constituents of excitable tissues of vertebrates. While carnosine and anserine are present at high concentrations and in variable proportions in skeleta...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-cysteinylglycine and the predominant intracellular antioxidant in many organisms including humans. GSH and associated enzymes are controlled by a transcription factor-nuclear factor-2 related erythroid factor-2 (Nrf2). In cellular milieu, GSH p...
journal_title:Current protein & peptide science
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更新日期:2019-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
abstract::Poly-N-acetyllactosamine structures occur in mammalian glycoproteins in both N- and O-linked glycans. They represent a backbone for additional modifications by fucosyltransferases, sialyltransferases and sulfotransferases. These glycans have been suggested to be involved in biospecific interactions with selectins and ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
abstract::Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledg...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920307781369454
更新日期:2007-08-01 00:00:00
abstract::Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages--the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagn...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140512120605
更新日期:2014-01-01 00:00:00
abstract::A growing body of work demonstrates the importance of post-transcriptional control, in particular translation initiation, in the overall regulation of gene expression. Here we focus on the contribution of regulatory elements within the 5' and 3' untranslated regions of mRNA to gene expression in eukaryotic cells inclu...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920312801619475
更新日期:2012-06-01 00:00:00
abstract::Changes in protein structure and function, alteration in protein-protein interaction, and significant difference in protein concentration inside the body could play an important role in indicating the pathological evidence of abnormalities before the development of clinical symptoms and act as a critical detection and...
journal_title:Current protein & peptide science
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更新日期:2020-01-01 00:00:00
abstract::Prostate cancer is one of the major threats to the man's health. There are several mechanisms of the prostate cancer development characterized by the involvement of various androgen-related and androgen-unrelated factors in prostate cancer pathogenesis and in the metastatic carcinogenesis of prostate. In all these pro...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Telobox is a Myb-related DNA-binding domain which is present in a number of yeast, plant and animal proteins. Its capacity to bind preferentially double-stranded telomeric DNA has been used in numerous studies to search for candidate telomeric proteins in various organisms, including plants. Here we provide an overvie...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920311795684968
更新日期:2011-03-01 00:00:00
abstract::Serine proteinases fulfill and facilitate a broad spectrum of biological processes. They are held in check by different specific inhibitors. This delicate balance can be disturbed by genetic defects or exogenous influences and has been shown as the underlying or promoting cause for a large number of different diseases...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203054065374
更新日期:2005-06-01 00:00:00