Amyloidogenicity of p53: a hidden link between protein misfolding and cancer.

abstract：:Cardiovascular (CV) diseases are caused by vascular dysfunction. The enhanced sensitivity to vasoconstrictors, reduced endothelium-derived vasodilators nitric oxide (NO) and prostacyclin (PGI2), and endothelium-derived hyperpolarization (EDH) indicate CV dysfunction. In recent years, recombinant human relaxin, known a...

journal_title：Current protein & peptide science

authors： Murtaza G,Siddiqui A,Hussain I

更新日期：2018-01-01 00:00:00

abstract：:Heart failure (HF) is a condition with high mortality worldwide characterized by persistent progression. Myocardial hypertrophy is a dominant feature during the early stage of HF. The development of HF is a complex process related to a series of physiologic and molecular factors. Although the treatment of HF has been ...

journal_title：Current protein & peptide science

authors： Bi Q

更新日期：2012-11-01 00:00:00

abstract：:Despite a wide variety of biological functions, alpha-helical membrane proteins display a rather simple transmembrane architecture. Although not many high resolution structures of transmembrane proteins are available today, our understanding of membrane protein folding has emerged in the recent years. Now we begin to ...

journal_title：Current protein & peptide science

authors： Schneider D,Finger C,Prodöhl A,Volkmer T

更新日期：2007-02-01 00:00:00

abstract：:Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...

journal_title：Current protein & peptide science

authors： Wong JH,Xia L,Ng TB

更新日期：2007-10-01 00:00:00

abstract：:Cell viability depends on the correct folding of the proteins involved in metabolism. Proteins are synthesized on the endoplasmic reticulum and must follow a pathway to a correct, metastable, tridimensional structure. Changes in structure or in environmental conditions can drive an instability of the folding condition...

journal_title：Current protein & peptide science

authors： de la Arada I,Andraka N,Pacios MG,Arrondo JL

更新日期：2011-05-01 00:00:00

abstract：:Flavonoids are plant products abundant in every day diet and claimed to be beneficial for human health. After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex. This review deals with the current state of knowledge on f...

journal_title：Current protein & peptide science

authors： Xue P,Zhang G,Zhang J,Ren L

更新日期：2020-11-08 00:00:00

abstract：:For several decades the specificity of proteases has been presented as an active site divided into subsites, using the nomenclature of Schechter & Berger from 1967 (S1, S2... for subsites of the active site; P1, P2... for residues of the substrate occupying the corresponding subsites). At early stages of the research ...

journal_title：Current protein & peptide science

authors： Schechter I

更新日期：2005-12-01 00:00:00

abstract：:STATs promote fundamental cellular processes, marking them as convergence points of many oncogenic and inflammatory pathways. Therefore, aberrant activation of STAT signaling is implicated in a plethora of human diseases, like cancer, inflammation and auto-immunity. Identification of STAT-specific inhibitors is the to...

journal_title：Current protein & peptide science

authors： Szelag M,Wesoly J,Bluyssen HA

更新日期：2016-01-01 00:00:00

abstract：:Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of bioge...

journal_title：Current protein & peptide science

authors： Fan P,Song P,Li L,Huang C,Chen J,Yang W,Qiao S,Wu G,Zhang G,Ma X

更新日期：2017-01-01 00:00:00

abstract：:The High mobility group box 1 (HMGB1) protein is an extremely versatile, highly conserved nuclear protein, with its unique intracellular and extracellular functions mediated by its relatively simple domain structure. Within the nucleus, HMGB1 binds to DNA minor groove in a nonspecific manner and causes bends in the do...

journal_title：Current protein & peptide science

authors： Lohani N,Rajeswari MR

更新日期：2016-01-01 00:00:00

abstract：:Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment, and eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of b...

journal_title：Current protein & peptide science

authors： Zhang W,Zhang Y,Zheng Y,Zheng M,Sun N,Yang X,Gao Y

更新日期：2019-01-01 00:00:00

abstract：:Staphylococcus aureus is a major cause of infection in humans and animals, causing a wide variety of diseases, from local inflammations to fatal sepsis. The bacterium is commonly multi-drug resistant and thus many front-line antibiotics have been rendered ineffective for treating such infections. Research on murein/pe...

journal_title：Current protein & peptide science

authors： Keary R,Sanz-Gaitero M,van Raaij MJ,O'Mahony J,Fenton M,McAuliffe O,Hill C,Ross RP,Coffey A

更新日期：2016-01-01 00:00:00

abstract：:Bacteria carry a battery of multidrug transporters, which belong to six families of transporters. Members of at least three families the ATP-Binding Cassette superfamily, the Major Facilitator Superfamily and the Multidrug Endosomal Transporter family have been shown to contribute to multidrug resistance phenotype in ...

journal_title：Current protein & peptide science

authors： Zgurskaya HI,Nikaido H

更新日期：2002-10-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) belongs to ErbB family of tyrosine kinases, which plays an important role in the regulation of cell proliferation, survival, differentiation, and metastasis. In addition, tumors develop resistance to EGFR inhibitors due to the presence or development of point mutations in th...

journal_title：Current protein & peptide science

authors： Wang X,Xu L,Lao Y,Zhang H,Xu H

更新日期：2018-02-13 00:00:00

abstract：:This article is a continuation of a series of reviews on the presence and the role of intrinsic disorder in milk proteins in the journal of Current Protein and Peptide Science. The focus of this article is on casein phosphopeptides, which are liberated during digestion of the milk protein casein. Structurally these ph...

journal_title：Current protein & peptide science

authors： Naqvi MA,Irani KA,Katanishooshtari M,Rousseau D

更新日期：2016-01-01 00:00:00

abstract：:Tic, short for 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, is a kind of unnatural α-amino acids. Due to its distinct geometrical conformation and biological activity, the structure of Tic, regarded as the surrogate of proline and the rigid analogue of phenylalanine or tyrosine, has been introduced into many comp...

journal_title：Current protein & peptide science

authors： Zhang Y,Fang H,Xu W

更新日期：2010-12-01 00:00:00

abstract：:Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...

journal_title：Current protein & peptide science

authors： Dürvanger Z,Harmat V

更新日期：2019-01-01 00:00:00

abstract：:The family of peptides designated as cathelicidins was identified over a decade ago. Cathelicidins have since gained increasing recognition, both as endogenous antibiotics and as effector molecules of the innate immune system. The human cathelicidin LL-37 is widely expressed in human tissues and plays diverse biologic...

journal_title：Current protein & peptide science

authors： Wong JH,Ye XJ,Ng TB

更新日期：2013-09-01 00:00:00

abstract：:Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...

journal_title：Current protein & peptide science

authors： Kentsis A,Borden KL

更新日期：2000-07-01 00:00:00

abstract：:Cardiomyocytes are best known for their spontaneous beating activity, large cell size, and low regenerative capacity during adulthood. The mechanical activity of cardiomyocytes depends on a sophisticated contractile apparatus comprised of sarcomeres whose rhythmic contraction relies on Ca(2+) transients with a high le...

journal_title：Current protein & peptide science

authors： Christians ES,Mustafi SB,Benjamin IJ

更新日期：2014-05-01 00:00:00

abstract：:By utilizing recently developed full-length cDNA technologies, large-scale cDNA sequencing was carried out by several cDNA projects. Now full-length cDNA resources cover the major part of the protein-coding human genes. Comprehensive analyses of the collected full-length cDNA data revealed not only the complete sequen...

journal_title：Current protein & peptide science

authors： Suzuki Y,Sugano S

更新日期：2006-04-01 00:00:00

abstract：:Secondary structure elements often mediate protein-protein interactions. Despite their low abundance in folded proteins, polyproline II (PPII) and its variant, the triple helix, are frequently involved in protein-protein interactions, likely due to their peculiar propensity to be solvent-exposed. We here review the ro...

journal_title：Current protein & peptide science

authors： Berisio R,Vitagliano L

更新日期：2012-12-01 00:00:00

abstract：:Photosynthetic organisms and isolated photosystems are of interest for technical applications. In nature, photosynthetic electron transport has to work efficiently in contrasting environments such as shade and full sunlight at noon. Photosynthetic electron transport is regulated on many levels, starting with the energ...

journal_title：Current protein & peptide science

authors： Roach T,Krieger-Liszkay A

更新日期：2014-01-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are cell surface receptors that transmit extracellular signals to the interior of the cell activating multiple signaling cascades: the binding of specific extracellular ligands activates RTKs which act as a scaffold at plasma membrane level for the recruitment and activation of several...

journal_title：Current protein & peptide science

authors： Salvi M

更新日期：2013-11-01 00:00:00

abstract：:CGRP and adrenomedullin [AM] are peptides that have a number of physiological effects, including vasodilation, through the activation of a shared GPCR, the family B calcitonin receptor-like receptor [CLR]. Specificity to each ligand is conferred through the unusual association of CLR with a single transmembrane access...

journal_title：Current protein & peptide science

authors： Woolley MJ,Conner AC

更新日期：2013-08-01 00:00:00

abstract：:We compare the DNA-interactive properties of bacteriophage T4 gene 32 protein (gp32) with those of crotamine, a component of the venom of the South American rattlesnake. Gene 32 protein is a classical single-stranded DNA binding protein that has served as a model for this class of proteins. We discuss its biological f...

journal_title：Current protein & peptide science

authors： Karpel RL

更新日期：2015-01-01 00:00:00

abstract：:It is now well established that the protein folding reaction proceeds via accumulation of various intermediate states. Osmolytes, besides their role in protein stabilization, have also been shown to possess the ability of inducing tremendous affects on these protein folding intermediates, reshape the folding pathway a...

journal_title：Current protein & peptide science

authors： Sharma GS,Dar TA,Singh LR

更新日期：2015-01-01 00:00:00

abstract：:The affinity tags are unique proteins/peptides that are attached at the N- or C-terminus of the recombinant proteins. These tags help in protein purification. Additionally, some affinity tags also serve a dual purpose as solubility enhancers for challenging protein targets. By applying a combinatorial approach, carefu...

journal_title：Current protein & peptide science

authors： Mishra V

更新日期：2020-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are type I transmembrane signaling molecules that are expressed in cells of the innate immune system. In these cells, TLRs function as pattern recognition receptors (PRR) that recognize specific molecular patterns derived from microorganisms. Upon activation, TLRs trigger a cascade of intrac...

journal_title：Current protein & peptide science

authors： Lee H,Lee S,Cho IH,Lee SJ

更新日期：2013-02-01 00:00:00

abstract：:Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages--the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagn...

journal_title：Current protein & peptide science

authors： Singh B,Singh S,Asif AR,Oellerich M,Sharma GL

更新日期：2014-01-01 00:00:00