Abstract:
:Toll-like receptors (TLRs) are type I transmembrane signaling molecules that are expressed in cells of the innate immune system. In these cells, TLRs function as pattern recognition receptors (PRR) that recognize specific molecular patterns derived from microorganisms. Upon activation, TLRs trigger a cascade of intracellular signaling pathways in innate immune cells, leading to the induction of inflammatory and innate immune responses, which in turn regulate adaptive immune responses. In the nervous system, different members of the TLR family are expressed on glial cells (astrocytes, microglia, oligodendrocytes, and Schwann cells) and neurons. Recently, increasing evidence has supported the idea that TLRs also recognize endogenous molecules that are released from damaged tissue, thereby regulating inflammatory responses and subsequent tissue repair. These findings imply that TLRs on glial cells may also be involved in the inflammatory response to tissue damage in the nervous system. In this review, we discuss recent studies on TLR expression in the cells of the nervous system and their roles in acute neurological disorders involving tissue damage such as strokes, traumatic spinal cord and brain injuries, and peripheral nerve injuries.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Lee H,Lee S,Cho IH,Lee SJdoi
10.2174/1389203711314010006subject
Has Abstractpub_date
2013-02-01 00:00:00pages
33-42issue
1eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-20130218-8journal_volume
14pub_type
杂志文章,评审abstract::SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...
journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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更新日期:2007-08-01 00:00:00
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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更新日期:2005-02-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Poly-N-acetyllactosamine structures occur in mammalian glycoproteins in both N- and O-linked glycans. They represent a backbone for additional modifications by fucosyltransferases, sialyltransferases and sulfotransferases. These glycans have been suggested to be involved in biospecific interactions with selectins and ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
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journal_title:Current protein & peptide science
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更新日期:2020-12-08 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666160226145217
更新日期:2016-01-01 00:00:00
abstract::Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is implicated as a major etiologic agent of adult periodontal disease. This bacterium is asaccharolytic and possesses strong potency for proteolysis. It produces a novel class of cysteine proteinases, termed gingipains, in the cell-associated and sec...
journal_title:Current protein & peptide science
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更新日期:2003-12-01 00:00:00
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
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abstract::Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...
journal_title:Current protein & peptide science
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更新日期:2014-01-01 00:00:00
abstract::The biotin carboxylase family is comprised of a group of enzymes that utilize a covalently bound prosthetic group, biotin, as a cofactor. These enzymes, which include acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranoyl-CoA carboxylase, oxaloacetate decarbox...
journal_title:Current protein & peptide science
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abstract::Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages--the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagn...
journal_title:Current protein & peptide science
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更新日期:2014-01-01 00:00:00
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journal_title:Current protein & peptide science
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abstract::Naturally occurring protease inhibitors (PI) of the Bowman-Birk type constitute a major PI family in cereal and legume seeds. The family name is derived from the names of the two investigators who characterised the first inhibitor of this type, the Bowman-Birk inhibitor from soybean (BBI). These proteins have the capa...
journal_title:Current protein & peptide science
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更新日期:2006-06-01 00:00:00
abstract::NOD Like Receptors (NLRs) are the most abundant cytoplasmic immune receptors in plants and animals and they similarly act sensing pathogen invasion and activating immune response. Despite the fact that plant and mammals NLRs share homology.; with some protein structure differences.; for signalling pathway.; divergent ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::The complement system is a major effector arm of the immune defense contributing to the destruction of invading pathogens. There are three possible routes of complement cascade activation: the classical, the alternative and the lectin pathways. The activation of the classical and lectin pathways is initiated by supram...
journal_title:Current protein & peptide science
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更新日期:2001-03-01 00:00:00