Structural heterogeneity and multifunctionality of lactoferrin.

abstract：:The current lack of complete understanding of the pathogenesis of acute kidney injury (AKI) is a significant barrier to its early diagnosis and treatment. Cell cycle arrest plays an important role in the protection of renal tubular epithelial cells and maladaptive repair following AKI. G1 phase cell arrest serves as a...

journal_title：Current protein & peptide science

authors： Wang WG,Sun WX,Gao BS,Lian X,Zhou HL

更新日期：2017-01-01 00:00:00

abstract：:Bacteria carry a battery of multidrug transporters, which belong to six families of transporters. Members of at least three families the ATP-Binding Cassette superfamily, the Major Facilitator Superfamily and the Multidrug Endosomal Transporter family have been shown to contribute to multidrug resistance phenotype in ...

journal_title：Current protein & peptide science

authors： Zgurskaya HI,Nikaido H

更新日期：2002-10-01 00:00:00

abstract：:The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensivel...

journal_title：Current protein & peptide science

authors： Liu Y,Liu S,Zhang X,Liang X,Zahid KR,Liu K,Liu J,Deng L,Yang J,Qi C

更新日期：2016-01-01 00:00:00

abstract：:The structure and stability of apolipoprotein (apo)A-I, the major apolipoprotein of human plasma high-density lipoproteins (HDL), determine the efficiency of the protein in the process of HDL generation and affect HDL properties in binding and exchanging its constituents, thus playing an essential role in reverse chol...

journal_title：Current protein & peptide science

authors： Dergunov AD,Garaeva EA,Savushkin EV,Litvinov DY

更新日期：2017-01-01 00:00:00

abstract：:Glycoconjugates comprise a variety of structures, include glycoproteins and glycolipids and are found on the surfaces of animal and plant cells, as well as on the surface of microorganisms. Determination of the structure and the distribution of glycoconjugates on cell surfaces are important for the understanding their...

journal_title：Current protein & peptide science

authors： Naeem A,Saleemuddin M,Khan RH

更新日期：2007-06-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are effector molecules of innate immune systems found in different groups of organisms, including microorganisms, plants, insects, amphibians and humans. These peptides exhibit several structural motifs but the most abundant AMPs assume an amphipathic alpha-helical structure. The alpha-he...

journal_title：Current protein & peptide science

authors： Castro MS,Cilli EM,Fontes W

更新日期：2006-12-01 00:00:00

abstract：:A complete understanding of the relationships between protein structure and stability remains an open problem. Much of our insight comes from laborious experimental analyses that perturb structure via directed mutation. The glycolytic enzyme lysozyme is among the most well characterized proteins under this paradigm, d...

journal_title：Current protein & peptide science

authors： Verma D,Jacobs DJ,Livesay DR

更新日期：2010-11-01 00:00:00

abstract：:Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive thera...

journal_title：Current protein & peptide science

authors： Lyu C,Fang F,Li B

更新日期：2019-01-01 00:00:00

abstract：:Structural and theoretical analyses of proteins are central to the understanding of complex molecular mechanisms and are fundamental to the drug discovery process. Computational techniques yield useful insights into an ever-wider range of biomolecular systems. Protein three-dimensional structures and molecular functio...

journal_title：Current protein & peptide science

authors： Villoutreix BO

更新日期：2002-06-01 00:00:00

abstract：:Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic c...

journal_title：Current protein & peptide science

authors： Chen H,Liu C,Cheng C,Zheng L,Huang K

更新日期：2018-01-01 00:00:00

abstract：:This work briefly describes available sensors for cAMP and cGMP. Many sensors are based on derivatization of naturally occurring products such as immunoglobulins, protein kinases, etc. Only a few published works deal with chemosensors, which are built up by "total" chemical synthesis. This field stays opened for combi...

journal_title：Current protein & peptide science

authors： Sebestík J,Hlavácek J,Stibor I

更新日期：2005-04-01 00:00:00

abstract：:Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...

journal_title：Current protein & peptide science

authors： Wong JH,Xia L,Ng TB

更新日期：2007-10-01 00:00:00

abstract：:Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myos...

journal_title：Current protein & peptide science

authors： Zheng W,Brooks BR,Thirumalai D

更新日期：2009-04-01 00:00:00

abstract：:Mites and ticks are associated with many human diseases including allergic diseases and scabies. With the recent advances in the high throughput DNA sequencing technology, many mitochondrial nuclear genomes of these species have been sequenced and the resulting genomic resources will certainly provide novel insights f...

journal_title：Current protein & peptide science

authors： Xiong Q,Wan ATY,Tsui SK

更新日期：2020-01-01 00:00:00

abstract：:Adipose tissue is not only a tissue where energy is stored but is also involved in regulating several body functions such as appetite and energy expenditure via its endocrine activity. Moreover, it thereby modulates complex processes like reproduction, inflammation and immune response. The products secreted from adipo...

journal_title：Current protein & peptide science

authors： Sauerwein H,Bendixen E,Restelli L,Ceciliani F

更新日期：2014-03-01 00:00:00

abstract：:Natural products serve as a main resource for drug discovery. The ubiquitin-proteasome system (UPS) is one of the primary intracellular protein degradation systems, which is responsible for the degradation of most short-lived, mis-folded and aged proteins. The proteasome is a validated target for cancer treatment, sin...

journal_title：Current protein & peptide science

authors： Wang H,Yang Q,Dou QP,Yang H

更新日期：2018-02-13 00:00:00

abstract：:Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)- type E3 ubiquitin ligase and also having SCF-independent activities. Mutations within FBXO7 have been found to cause an early-onset Parkinson's disease, and these are found within or near to its functional domains, including its F-...

journal_title：Current protein & peptide science

authors： Randle SJ,Laman H

更新日期：2017-01-01 00:00:00

abstract：:The number of protein folds in nature is limited, thus is not surprising that proteins with the same fold are able to exert different functions. The cysteine protease inhibitors that adopt an immunoglobulin- like fold (Ig-ICPs) are inhibitors encoded in bacteria and protozoan parasites. Structural studies indicate tha...

journal_title：Current protein & peptide science

authors： Jimenez-Sandoval P,Lopez-Castillo LM,Trasviña-Arenas CH,Brieba LG

更新日期：2017-01-01 00:00:00

abstract：:The bioactive peptides are protein fragments which have a positive impact on the intestinal homeostasis. Intestinal homeostasis depends on the diverse functions of intestinal barrier including the microbiological, physical, chemical and immunological barriers. Defects in intestinal barrier function are associated with...

journal_title：Current protein & peptide science

authors： Ji J,Qu H,Shu D

更新日期：2015-01-01 00:00:00

abstract：:We compare the DNA-interactive properties of bacteriophage T4 gene 32 protein (gp32) with those of crotamine, a component of the venom of the South American rattlesnake. Gene 32 protein is a classical single-stranded DNA binding protein that has served as a model for this class of proteins. We discuss its biological f...

journal_title：Current protein & peptide science

authors： Karpel RL

更新日期：2015-01-01 00:00:00

abstract：:SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...

journal_title：Current protein & peptide science

authors： Korsinczky ML,Schirra HJ,Craik DJ

更新日期：2004-10-01 00:00:00

abstract：:Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing "treasure trove" o...

journal_title：Current protein & peptide science

authors： Wilson DN,Blaha G,Connell SR,Ivanov PV,Jenke H,Stelzl U,Teraoka Y,Nierhaus KH

更新日期：2002-02-01 00:00:00

abstract：:Poly-N-acetyllactosamine structures occur in mammalian glycoproteins in both N- and O-linked glycans. They represent a backbone for additional modifications by fucosyltransferases, sialyltransferases and sulfotransferases. These glycans have been suggested to be involved in biospecific interactions with selectins and ...

journal_title：Current protein & peptide science

authors： Zhou D

更新日期：2003-02-01 00:00:00

abstract：:Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...

journal_title：Current protein & peptide science

authors： Turra D,Lorito M

更新日期：2011-08-01 00:00:00

abstract：:Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functional...

journal_title：Current protein & peptide science

authors： Permyakov EA,Uversky VN,Permyakov SE

更新日期：2017-01-01 00:00:00

abstract：:As global resistance to conventional antibiotics rises we need to develop new strategies to develop future novel therapeutics. In our quest to design novel anti-infectives and antimicrobials it is of interest to investigate host-pathogen interactions and learn from the complexity of host defense strategies that have e...

journal_title：Current protein & peptide science

authors： Augustyniak D,Nowak J,Lundy FT

更新日期：2012-12-01 00:00:00

abstract：:Serine proteinases fulfill and facilitate a broad spectrum of biological processes. They are held in check by different specific inhibitors. This delicate balance can be disturbed by genetic defects or exogenous influences and has been shown as the underlying or promoting cause for a large number of different diseases...

journal_title：Current protein & peptide science

authors： Mägert HJ,Drögemüller K,Raghunath M

更新日期：2005-06-01 00:00:00

abstract：:In spite of the relevance of the results obtained through the clinical application of chemotherapeutic agents (reverse transcriptase and proteinase inhibitors) that are able to prolong the life span of affected people, acquired immunodeficiency syndrome (AIDS) remains a serious and lethal disease. AIDS is caused by a ...

journal_title：Current protein & peptide science

authors： Di Bello C,Pasquato A,Dettin M

更新日期：2004-08-01 00:00:00

abstract：:Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...

journal_title：Current protein & peptide science

authors： Kentsis A,Borden KL

更新日期：2000-07-01 00:00:00

abstract：:Arginine is widely used in such applications as protein refolding, solubilization of proteins and small molecules, protein and small molecule formulation, column chromatography and viral inactivation as summarized in this review. What makes arginine effective in these applications is largely based on its ability to su...

journal_title：Current protein & peptide science

authors： Arakawa T,Kita Y

更新日期：2014-01-01 00:00:00