Using the telobox to search for plant telomere binding proteins.

abstract：:The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensivel...

journal_title：Current protein & peptide science

authors： Liu Y,Liu S,Zhang X,Liang X,Zahid KR,Liu K,Liu J,Deng L,Yang J,Qi C

更新日期：2016-01-01 00:00:00

abstract：:Prostate cancer is one of the major threats to the man's health. There are several mechanisms of the prostate cancer development characterized by the involvement of various androgen-related and androgen-unrelated factors in prostate cancer pathogenesis and in the metastatic carcinogenesis of prostate. In all these pro...

journal_title：Current protein & peptide science

authors： Uversky VN,Na I,Landau KS,Schenck RO

更新日期：2017-01-01 00:00:00

abstract：:Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...

journal_title：Current protein & peptide science

authors： Turra D,Lorito M

更新日期：2011-08-01 00:00:00

abstract：:The absence of uracil from DNA genomes is a consequence of enzyme functions that eliminate intracellular dUTP pools and that purposefully recognize and remove uracil moieties from DNA. These enzymatic functions are dUTP nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UDG), respectively. There are distinct nu...

journal_title：Current protein & peptide science

authors： Caradonna S,Muller-Weeks S

更新日期：2001-12-01 00:00:00

abstract：:Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved m...

journal_title：Current protein & peptide science

authors： Rabbani G,Baig MH,Ahmad K,Choi I

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In the search of bioactive molecules, nature has always been an important source and most of the drugs in clinic are either natural products or derived from natural products. The ocean has played significant role as thousands of molecules and their metabolites with different types of biological activity such...

journal_title：Current protein & peptide science

authors： Negi B,Kumar D,Rawat DS

更新日期：2017-01-01 00:00:00

abstract：:NOD Like Receptors (NLRs) are the most abundant cytoplasmic immune receptors in plants and animals and they similarly act sensing pathogen invasion and activating immune response. Despite the fact that plant and mammals NLRs share homology.; with some protein structure differences.; for signalling pathway.; divergent ...

journal_title：Current protein & peptide science

authors： Pontillo A,Crovella S

更新日期：2017-01-01 00:00:00

abstract：:Flavonoids are plant products abundant in every day diet and claimed to be beneficial for human health. After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex. This review deals with the current state of knowledge on f...

journal_title：Current protein & peptide science

authors： Xue P,Zhang G,Zhang J,Ren L

更新日期：2020-11-08 00:00:00

abstract：:Heart failure (HF) is a condition with high mortality worldwide characterized by persistent progression. Myocardial hypertrophy is a dominant feature during the early stage of HF. The development of HF is a complex process related to a series of physiologic and molecular factors. Although the treatment of HF has been ...

journal_title：Current protein & peptide science

authors： Bi Q

更新日期：2012-11-01 00:00:00

abstract：:Arginine is widely used in such applications as protein refolding, solubilization of proteins and small molecules, protein and small molecule formulation, column chromatography and viral inactivation as summarized in this review. What makes arginine effective in these applications is largely based on its ability to su...

journal_title：Current protein & peptide science

authors： Arakawa T,Kita Y

更新日期：2014-01-01 00:00:00

abstract：:The interactions of ligands with biomacromolecules play a fundamental role in almost all bioprocesses occuring in living organisms. The binding of ligands can cause the conformational changes of biomacromolecules, possibly affecting their physiological functions. The interactions of ligands with biomacromolecules are ...

journal_title：Current protein & peptide science

authors： Zhang W,Pan L,Wang H,Lv X,Ding K

更新日期：2017-01-01 00:00:00

abstract：:The Mastermind-like (MAML) proteins are transcriptional coactivators for Notch signaling, an evolutionarily conserved pathway that plays several key roles in development and in human disease. The MAML family contains MAML1, MAML2, and MAML3. More recently, MAML1 has been shown to function as a coactivator for the tumo...

journal_title：Current protein & peptide science

authors： Saint Just Ribeiro M,Wallberg AE

更新日期：2009-12-01 00:00:00

abstract：:Skeletal muscle, the main protein reservoir in the body, is a tissue that exhibits high plasticity when exposed to changes. Muscle proteins can be mobilized into free amino acids when skeletal muscle wasting occurs, a process called skeletal muscle atrophy. This wasting is an important systemic or local manifestation ...

journal_title：Current protein & peptide science

authors： Cabello-Verrugio C,Córdova G,Salas JD

更新日期：2012-09-01 00:00:00

abstract：:Host cell entry by influenza and other enveloped viruses is well characterized, however, the manner in which non-enveloped viruses deliver their genome across host cell membranes in the absence of membrane fusion remains unresolved. The discovery of short, membrane altering, amphipathic or hydrophobic sequences in sev...

journal_title：Current protein & peptide science

authors： Banerjee M,Johnson JE

更新日期：2008-02-01 00:00:00

abstract：:Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledg...

journal_title：Current protein & peptide science

authors： Kishan KV

更新日期：2007-08-01 00:00:00

abstract：:Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive thera...

journal_title：Current protein & peptide science

authors： Lyu C,Fang F,Li B

更新日期：2019-01-01 00:00:00

abstract：:Prediction of protein domain boundaries is an important step for the prediction of three-dimensional structure. The simple method PDP has been elaborated for prediction of the number and position of domain boundaries in multi-domain proteins by use of amino acid sequence alone. The method uses an optimized scale based...

journal_title：Current protein & peptide science

authors： Dovidchenko NV,Lobanov MY,Galzitskaya OV

更新日期：2007-04-01 00:00:00

abstract：:Peptides act as promising anticancer agents due to their ease of synthesis and modifications, enhanced tumor penetration, and less systemic toxicity. However, only limited success has been achieved so far, as experimental design and synthesis of anticancer peptides (ACPs) are prohibitively costly and time-consuming. F...

journal_title：Current protein & peptide science

authors： Basith S,Manavalan B,Shin TH,Lee DY,Lee G

更新日期：2020-01-01 00:00:00

abstract：:Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment, and eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of b...

journal_title：Current protein & peptide science

authors： Zhang W,Zhang Y,Zheng Y,Zheng M,Sun N,Yang X,Gao Y

更新日期：2019-01-01 00:00:00

abstract：:Photosynthetic organisms and isolated photosystems are of interest for technical applications. In nature, photosynthetic electron transport has to work efficiently in contrasting environments such as shade and full sunlight at noon. Photosynthetic electron transport is regulated on many levels, starting with the energ...

journal_title：Current protein & peptide science

authors： Roach T,Krieger-Liszkay A

更新日期：2014-01-01 00:00:00

abstract：:Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...

journal_title：Current protein & peptide science

authors： Dürvanger Z,Harmat V

更新日期：2019-01-01 00:00:00

abstract：:While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now recognized, deciphering their molecular mode of action at the structural level still remains highly challenging and requires a combination of many biophysical approaches. Among them, small angle X-ray scattering (SAXS) has been...

journal_title：Current protein & peptide science

authors： Receveur-Brechot V,Durand D

更新日期：2012-02-01 00:00:00

abstract：:The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of pro...

journal_title：Current protein & peptide science

authors： Veljkovic N,Glisic S,Prljic J,Perovic V,Botta M,Veljkovic V

更新日期：2008-10-01 00:00:00

abstract：:The bioactive peptides are protein fragments which have a positive impact on the intestinal homeostasis. Intestinal homeostasis depends on the diverse functions of intestinal barrier including the microbiological, physical, chemical and immunological barriers. Defects in intestinal barrier function are associated with...

journal_title：Current protein & peptide science

authors： Ji J,Qu H,Shu D

更新日期：2015-01-01 00:00:00

abstract：:Identifying the interactions between drugs and target proteins is a key step in drug discovery. This not only aids to understand the disease mechanism, but also helps to identify unexpected therapeutic activity or adverse side effects of drugs. Hence, drug-target interaction prediction becomes an essential tool in the...

journal_title：Current protein & peptide science

authors： Anusuya S,Kesherwani M,Priya KV,Vimala A,Shanmugam G,Velmurugan D,Gromiha MM

更新日期：2018-01-01 00:00:00

abstract：:Cardiomyocytes are best known for their spontaneous beating activity, large cell size, and low regenerative capacity during adulthood. The mechanical activity of cardiomyocytes depends on a sophisticated contractile apparatus comprised of sarcomeres whose rhythmic contraction relies on Ca(2+) transients with a high le...

journal_title：Current protein & peptide science

authors： Christians ES,Mustafi SB,Benjamin IJ

更新日期：2014-05-01 00:00:00

abstract：:Elevated blood pressure or hypertension is one of the fastest growing health problems worldwide. Although the etiology of essential hypertension has a genetic component, dietary factors play an important role. With the high costs and adverse side-effects associated with synthetic antihypertensive drugs and the awarene...

journal_title：Current protein & peptide science

authors： Harnedy PA,FitzGerald RJ

更新日期：2013-05-01 00:00:00

abstract：:Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functional...

journal_title：Current protein & peptide science

authors： Permyakov EA,Uversky VN,Permyakov SE

更新日期：2017-01-01 00:00:00

abstract：:A growing body of work demonstrates the importance of post-transcriptional control, in particular translation initiation, in the overall regulation of gene expression. Here we focus on the contribution of regulatory elements within the 5' and 3' untranslated regions of mRNA to gene expression in eukaryotic cells inclu...

journal_title：Current protein & peptide science

authors： Pichon X,Wilson LA,Stoneley M,Bastide A,King HA,Somers J,Willis AE

更新日期：2012-06-01 00:00:00

abstract：:CD2 (cluster of differentiation 2) is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). Tremendous progress has been achieved in understanding the function of CD2, the mechanism of molecular recognition and protein folding, thus, leading towards the use of t...

journal_title：Current protein & peptide science

authors： Wilkins AL,Yang W,Yang JJ

更新日期：2003-10-01 00:00:00