Abstract:
:Arginine is widely used in such applications as protein refolding, solubilization of proteins and small molecules, protein and small molecule formulation, column chromatography and viral inactivation as summarized in this review. What makes arginine effective in these applications is largely based on its ability to suppress protein-protein interactions and protein-surface interactions. The mechanism of these widespread effects of arginine on proteins can be explained at least in part from its unique interactions with the protein surface. Here we describe the modes of the interactions of arginine with model compounds and proteins and also water molecules, and then attempt to explain the mechanism of its effect on proteins by comparing with the interactions that occur between protein and protein denaturants or stabilizers.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Arakawa T,Kita Ydoi
10.2174/138920371506140818113015subject
Has Abstractpub_date
2014-01-01 00:00:00pages
608-20issue
6eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-59294journal_volume
15pub_type
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