Abstract:
:Structure based drug designing is now a popular technique used for increasing the speed of drug designing process. This was made possible by the availability of many protein structures which helped in developing tools to understand the structure function relationships, automated docking and virtual screening. Knowledge of structure based functional properties of a drug target is very essential for a successful in silico designing of drugs. However, some problems associated with the structure determination process and lack of knowledge of conformational freedom associated with available protein structures are the hurdles involved in structure based drug designing. Docking and virtual screening processes depend on the active site structure of the receptor molecule and subtle differences in the conformations of these molecules due to flexibility pose a serious threat to the drug designing process. In this review problems associated with the conformations of proteins and homology models was reviewed.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Kishan KVdoi
10.2174/138920307781369454subject
Has Abstractpub_date
2007-08-01 00:00:00pages
376-80issue
4eissn
1389-2037issn
1875-5550journal_volume
8pub_type
杂志文章,评审abstract::Receptor tyrosine kinases (RTKs) are cell surface receptors that transmit extracellular signals to the interior of the cell activating multiple signaling cascades: the binding of specific extracellular ligands activates RTKs which act as a scaffold at plasma membrane level for the recruitment and activation of several...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/13892037113146660087
更新日期:2013-11-01 00:00:00
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journal_title:Current protein & peptide science
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abstract::Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functional...
journal_title:Current protein & peptide science
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abstract::Naturally occurring protease inhibitors (PI) of the Bowman-Birk type constitute a major PI family in cereal and legume seeds. The family name is derived from the names of the two investigators who characterised the first inhibitor of this type, the Bowman-Birk inhibitor from soybean (BBI). These proteins have the capa...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920306777452349
更新日期:2006-06-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
abstract::The review presents three hypotheses concerning the amino acid complementarity: 1) the Mekler-Blalock antisense hypothesis; 2) the Root-Bernstein approach based on stereochemical complementarity of amino acids and anti-amino acids coded by anticodons read in parallel with the coding DNA strand; 3) Siemion hypothesis r...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2004-12-01 00:00:00
abstract::The Mastermind-like (MAML) proteins are transcriptional coactivators for Notch signaling, an evolutionarily conserved pathway that plays several key roles in development and in human disease. The MAML family contains MAML1, MAML2, and MAML3. More recently, MAML1 has been shown to function as a coactivator for the tumo...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920309789630543
更新日期:2009-12-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
abstract::Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140919124530
更新日期:2014-01-01 00:00:00
abstract::The cytolysin is a novel, two-peptide lytic toxin produced by some strains of Enterococcus faecalis. It is toxic in animal models of enterococcal infection, and associated with acutely terminal outcome in human infection. The cytolysin exerts activity against a broad spectrum of cell types including a wide range of gr...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666150330141638
更新日期:2015-01-01 00:00:00
abstract::Fungal diseases are severe and have very high morbidity as well as up to 60% mortality for patients diagnosed with invasive fungal infection. In this review, in vitro and in vivo studies provided us with the insight into the role of Candida virulence factors that mediate their success as pathogens, such as: membrane a...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203720666190722152415
更新日期:2020-01-01 00:00:00
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journal_title:Current protein & peptide science
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203719666171213114919
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journal_title:Current protein & peptide science
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更新日期:2012-06-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
abstract::Serine proteases and their natural inhibitors have long been served as excellent models for studying (primary, secondary and tertiary) structure - activity relationships of biologically interacting proteins. As protein flexibility has been accepted as a "fourth dimension" of the protein structure, its contribution to ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variatio...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203033487252
更新日期:2003-04-01 00:00:00
abstract::The current lack of complete understanding of the pathogenesis of acute kidney injury (AKI) is a significant barrier to its early diagnosis and treatment. Cell cycle arrest plays an important role in the protection of renal tubular epithelial cells and maladaptive repair following AKI. G1 phase cell arrest serves as a...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...
journal_title:Current protein & peptide science
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更新日期:2020-01-01 00:00:00
abstract::Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...
journal_title:Current protein & peptide science
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abstract::The structure and stability of apolipoprotein (apo)A-I, the major apolipoprotein of human plasma high-density lipoproteins (HDL), determine the efficiency of the protein in the process of HDL generation and affect HDL properties in binding and exchanging its constituents, thus playing an essential role in reverse chol...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666160713150223
更新日期:2017-01-01 00:00:00
abstract::For several decades the specificity of proteases has been presented as an active site divided into subsites, using the nomenclature of Schechter & Berger from 1967 (S1, S2... for subsites of the active site; P1, P2... for residues of the substrate occupying the corresponding subsites). At early stages of the research ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00