Abstract:
:A growing body of work demonstrates the importance of post-transcriptional control, in particular translation initiation, in the overall regulation of gene expression. Here we focus on the contribution of regulatory elements within the 5' and 3' untranslated regions of mRNA to gene expression in eukaryotic cells including terminal oligopyrimidine tracts, internal ribosome entry segments, upstream open reading frames and cytoplasmic polyadenylation elements. These mRNA regulatory elements may adopt complex secondary structures and/or contain sequence motifs that allow their interaction with a variety of regulatory proteins, RNAs and RNA binding proteins, particularly hnRNPs. The resulting interactions are context-sensitive, and provide cells with a sensitive and fast response to cellular signals such as hormone exposure or cytotoxic stress. Importantly, an increasing number of diseases have been identified, particularly cancers and those associated with neurodegeneration, which originate either from mutation of these regulatory motifs, or from deregulation of their cognate binding partners.
journal_name
Curr Protein Pept Scijournal_title
Current protein & peptide scienceauthors
Pichon X,Wilson LA,Stoneley M,Bastide A,King HA,Somers J,Willis AEdoi
10.2174/138920312801619475subject
Has Abstractpub_date
2012-06-01 00:00:00pages
294-304issue
4eissn
1389-2037issn
1875-5550pii
CPPS-EPUB-20120618-7journal_volume
13pub_type
杂志文章,评审abstract::The review presents three hypotheses concerning the amino acid complementarity: 1) the Mekler-Blalock antisense hypothesis; 2) the Root-Bernstein approach based on stereochemical complementarity of amino acids and anti-amino acids coded by anticodons read in parallel with the coding DNA strand; 3) Siemion hypothesis r...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379413
更新日期:2004-12-01 00:00:00
abstract::In spite of the relevance of the results obtained through the clinical application of chemotherapeutic agents (reverse transcriptase and proteinase inhibitors) that are able to prolong the life span of affected people, acquired immunodeficiency syndrome (AIDS) remains a serious and lethal disease. AIDS is caused by a ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379729
更新日期:2004-08-01 00:00:00
abstract::This work briefly describes available sensors for cAMP and cGMP. Many sensors are based on derivatization of naturally occurring products such as immunoglobulins, protein kinases, etc. Only a few published works deal with chemosensors, which are built up by "total" chemical synthesis. This field stays opened for combi...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203053545408
更新日期:2005-04-01 00:00:00
abstract::Proteasomes are the major nonlysosomal protein degradation machinery in eukaryotic cells and they are largely responsible for the processing of antigens for presentation by the MHC class I pathway. This review concentrates on recent developments in the area of antigen processing. Specialized proteasomes called immunop...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379774
更新日期:2004-06-01 00:00:00
abstract::Host cell entry by influenza and other enveloped viruses is well characterized, however, the manner in which non-enveloped viruses deliver their genome across host cell membranes in the absence of membrane fusion remains unresolved. The discovery of short, membrane altering, amphipathic or hydrophobic sequences in sev...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920308783565732
更新日期:2008-02-01 00:00:00
abstract::Here we review the present state of structural and functional studies of the Sac10b protein family, a class of highly conserved 10 kDa nucleic acid-binding proteins in archaea. Based on biochemical and structural studies, these proteins were originally assigned a role in the structural organization of chromatin; Sac10...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920312800785067
更新日期:2012-05-01 00:00:00
abstract::Cardiomyocytes are best known for their spontaneous beating activity, large cell size, and low regenerative capacity during adulthood. The mechanical activity of cardiomyocytes depends on a sophisticated contractile apparatus comprised of sarcomeres whose rhythmic contraction relies on Ca(2+) transients with a high le...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140331111518
更新日期:2014-05-01 00:00:00
abstract::The structure and stability of apolipoprotein (apo)A-I, the major apolipoprotein of human plasma high-density lipoproteins (HDL), determine the efficiency of the protein in the process of HDL generation and affect HDL properties in binding and exchanging its constituents, thus playing an essential role in reverse chol...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666160713150223
更新日期:2017-01-01 00:00:00
abstract::Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment, and eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of b...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203720666190125095819
更新日期:2019-01-01 00:00:00
abstract::Viscosity of protein solution is one of the most troublesome issues for the high-concentration formulation of protein drugs. In this review, we summarize the practical methods that suppress the viscosity of protein solution using small molecular additives. The small amount of salts decreases the viscosity that results...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203719666171213114919
更新日期:2018-01-01 00:00:00
abstract::Despite a wide variety of biological functions, alpha-helical membrane proteins display a rather simple transmembrane architecture. Although not many high resolution structures of transmembrane proteins are available today, our understanding of membrane protein folding has emerged in the recent years. Now we begin to ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920307779941578
更新日期:2007-02-01 00:00:00
abstract::Naturally occurring protease inhibitors (PI) of the Bowman-Birk type constitute a major PI family in cereal and legume seeds. The family name is derived from the names of the two investigators who characterised the first inhibitor of this type, the Bowman-Birk inhibitor from soybean (BBI). These proteins have the capa...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920306777452349
更新日期:2006-06-01 00:00:00
abstract::Cell viability depends on the correct folding of the proteins involved in metabolism. Proteins are synthesized on the endoplasmic reticulum and must follow a pathway to a correct, metastable, tridimensional structure. Changes in structure or in environmental conditions can drive an instability of the folding condition...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920311795860142
更新日期:2011-05-01 00:00:00
abstract::Poly-N-acetyllactosamine structures occur in mammalian glycoproteins in both N- and O-linked glycans. They represent a backbone for additional modifications by fucosyltransferases, sialyltransferases and sulfotransferases. These glycans have been suggested to be involved in biospecific interactions with selectins and ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203033380304
更新日期:2003-02-01 00:00:00
abstract::Serine proteases and their natural inhibitors have long been served as excellent models for studying (primary, secondary and tertiary) structure - activity relationships of biologically interacting proteins. As protein flexibility has been accepted as a "fourth dimension" of the protein structure, its contribution to ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666150429123733
更新日期:2015-01-01 00:00:00
abstract::STATs promote fundamental cellular processes, marking them as convergence points of many oncogenic and inflammatory pathways. Therefore, aberrant activation of STAT signaling is implicated in a plethora of human diseases, like cancer, inflammation and auto-immunity. Identification of STAT-specific inhibitors is the to...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203716666151102103706
更新日期:2016-01-01 00:00:00
abstract::Photosynthetic organisms and isolated photosystems are of interest for technical applications. In nature, photosynthetic electron transport has to work efficiently in contrasting environments such as shade and full sunlight at noon. Photosynthetic electron transport is regulated on many levels, starting with the energ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203715666140327105143
更新日期:2014-01-01 00:00:00
abstract::Skeletal muscle, the main protein reservoir in the body, is a tissue that exhibits high plasticity when exposed to changes. Muscle proteins can be mobilized into free amino acids when skeletal muscle wasting occurs, a process called skeletal muscle atrophy. This wasting is an important systemic or local manifestation ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920312803582933
更新日期:2012-09-01 00:00:00
abstract::An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203720666190729122614
更新日期:2020-01-01 00:00:00
abstract::Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...
journal_title:Current protein & peptide science
pub_type: 杂志文章
doi:10.2174/1389203003381478
更新日期:2000-07-01 00:00:00
abstract::ATPases are important molecular machines that convert the chemical energies stored in ATP to mechanical actions within the cell. ATPases are among the most abundant proteins with diverse functions involved in almost every cellular pathway. The well characterised ATPases include the various motor proteins responsible f...
journal_title:Current protein & peptide science
pub_type: 杂志文章
doi:10.2174/1389203043486874
更新日期:2004-04-01 00:00:00
abstract::Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Rehmanniae Radix Praeparata (RRP) is a popular medicinal herb widely used in traditional Chinese medicine (TCM) to treat CVDs. However, the development of this novel therapeutic product has been stagnant, and its molecular mechanism of action...
journal_title:Current protein & peptide science
pub_type: 杂志文章
doi:10.2174/1389203720666190610161535
更新日期:2019-01-01 00:00:00
abstract::Cardiovascular (CV) diseases are caused by vascular dysfunction. The enhanced sensitivity to vasoconstrictors, reduced endothelium-derived vasodilators nitric oxide (NO) and prostacyclin (PGI2), and endothelium-derived hyperpolarization (EDH) indicate CV dysfunction. In recent years, recombinant human relaxin, known a...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203719666180709103020
更新日期:2018-01-01 00:00:00
abstract::Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved m...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666170828122927
更新日期:2018-01-01 00:00:00
abstract::Tribbles homolog 3 (TRIB3) is a mammalian gene that is upregulated in response to several types of cell death-inducing cellular stress. The TRIB3 protein is a pseudokinase, a protein kinase-like scaffold with impaired catalytic activity. However, research has revealed it to be prolific at forming protein- protein inte...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666170406124547
更新日期:2017-01-01 00:00:00
abstract::For several decades the specificity of proteases has been presented as an active site divided into subsites, using the nomenclature of Schechter & Berger from 1967 (S1, S2... for subsites of the active site; P1, P2... for residues of the substrate occupying the corresponding subsites). At early stages of the research ...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/138920305774933286
更新日期:2005-12-01 00:00:00
abstract::Prostate cancer is one of the major threats to the man's health. There are several mechanisms of the prostate cancer development characterized by the involvement of various androgen-related and androgen-unrelated factors in prostate cancer pathogenesis and in the metastatic carcinogenesis of prostate. In all these pro...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203717666161028145848
更新日期:2017-01-01 00:00:00
abstract::Carnosine (β-alanyl-L-histidine) and its methylated derivatives: anserine (β-alanyl-Nπ- methyl-L-histidine) and balenine (β-alanyl-Nτ-methyl-L-histidine) are abundant constituents of excitable tissues of vertebrates. While carnosine and anserine are present at high concentrations and in variable proportions in skeleta...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203719666180226155657
更新日期:2018-01-01 00:00:00
abstract::SFTI-1 is a bicyclic 14 amino acid peptide that was originally isolated from the seeds of the sunflower Helianthus annuus. It is a potent inhibitor of trypsin, with a sub-nanomolar K(i) value and is homologous to the active site region of the well-known family of serine protease inhibitors known as the Bowman-Birk try...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203043379594
更新日期:2004-10-01 00:00:00
abstract::The lipid bilayer of the plasma membrane is a selective impermeable barrier for the internalization of most macromolecules. Cell penetrating peptides (CPPs) could cross the plasma membrane barrier to deliver various molecules into cells and are considered as a promising tool to deliver macromolecular drugs. However, t...
journal_title:Current protein & peptide science
pub_type: 杂志文章,评审
doi:10.2174/1389203718666170710115240
更新日期:2018-01-01 00:00:00