The problem of amino acid complementarity and antisense peptides.

abstract：:Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...

journal_title：Current protein & peptide science

authors： Dürvanger Z,Harmat V

更新日期：2019-01-01 00:00:00

abstract：:Prediction of protein domain boundaries is an important step for the prediction of three-dimensional structure. The simple method PDP has been elaborated for prediction of the number and position of domain boundaries in multi-domain proteins by use of amino acid sequence alone. The method uses an optimized scale based...

journal_title：Current protein & peptide science

authors： Dovidchenko NV,Lobanov MY,Galzitskaya OV

更新日期：2007-04-01 00:00:00

abstract：:Flavonoids are plant products abundant in every day diet and claimed to be beneficial for human health. After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex. This review deals with the current state of knowledge on f...

journal_title：Current protein & peptide science

authors： Xue P,Zhang G,Zhang J,Ren L

更新日期：2020-11-08 00:00:00

abstract：:ATPases are important molecular machines that convert the chemical energies stored in ATP to mechanical actions within the cell. ATPases are among the most abundant proteins with diverse functions involved in almost every cellular pathway. The well characterised ATPases include the various motor proteins responsible f...

journal_title：Current protein & peptide science

authors： Rappas M,Niwa H,Zhang X

更新日期：2004-04-01 00:00:00

abstract：:Proteasomes are the major nonlysosomal protein degradation machinery in eukaryotic cells and they are largely responsible for the processing of antigens for presentation by the MHC class I pathway. This review concentrates on recent developments in the area of antigen processing. Specialized proteasomes called immunop...

journal_title：Current protein & peptide science

authors： Rivett AJ,Hearn AR

更新日期：2004-06-01 00:00:00

abstract：:Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in the enteroend...

journal_title：Current protein & peptide science

authors： Thulesen J

更新日期：2004-02-01 00:00:00

abstract：:Pathogenic aggregation is closely associated with various protein misfolding diseases such as type 2 diabetes mellitus and Alzheimer's disease. Amyloidogenic proteins that have a propensity to assemble into amyloid oligomers and fibrils form the aggregates. The tumor suppressor p53, a transcription factor that regulat...

journal_title：Current protein & peptide science

authors： Gong H,Yang X,Zhao Y,Petersen RB,Liu X,Liu Y,Huang K

更新日期：2015-01-01 00:00:00

abstract：:Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is implicated as a major etiologic agent of adult periodontal disease. This bacterium is asaccharolytic and possesses strong potency for proteolysis. It produces a novel class of cysteine proteinases, termed gingipains, in the cell-associated and sec...

journal_title：Current protein & peptide science

authors： Kadowaki T,Yamamoto K

更新日期：2003-12-01 00:00:00

abstract：:The needs for purified nucleic acids for preparative and analytical applications have increased constantly, demanding for the development of new and more efficient methods for their recovery and isolation. DNA molecules harbour some intrinsic chemical properties that render them suitable for chromatographic separation...

journal_title：Current protein & peptide science

authors： Matos T,Bülow L

更新日期：2019-01-01 00:00:00

abstract：:The absence of uracil from DNA genomes is a consequence of enzyme functions that eliminate intracellular dUTP pools and that purposefully recognize and remove uracil moieties from DNA. These enzymatic functions are dUTP nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UDG), respectively. There are distinct nu...

journal_title：Current protein & peptide science

authors： Caradonna S,Muller-Weeks S

更新日期：2001-12-01 00:00:00

abstract：:The majority of tRNA studies has focused on tRNA molecules as pivotal player in the fundamental process of protein synthesis. Mounting studies have unveiled further functions for tRNA beyond protein synthesis, including non-ribosomal amino acid transfer, and regulation of targeted proteolysis. Post-translational N-ter...

journal_title：Current protein & peptide science

authors： Eldeeb MA,Ragheb MA

更新日期：2018-01-01 00:00:00

abstract：:Covalent conjugation of the ubiquitin tag to cellular proteins plays a central role in a number of processes, the most notable among them being degradation by the 26S proteasome. A fundamental property of this process is that ubiquitination, in contrast to subsequent degradation, is reversible due to a number of deubi...

journal_title：Current protein & peptide science

authors： Guterman A,Glickman MH

更新日期：2004-06-01 00:00:00

abstract：:There has been a tremendous increase in the number of approved drugs derived from recombinant proteins; however, their development as potential drugs has been hampered by their instability that causes difficulty to formulate them as therapeutic agents. It has been shown that the reactivity of thiol and disulfide funct...

journal_title：Current protein & peptide science

authors： Trivedi MV,Laurence JS,Siahaan TJ

更新日期：2009-12-01 00:00:00

abstract：:Alpha-fetoprotein (AFP), known largely as a growth-promoting agent, possesses a growth-inhibitory motif recently identified as an occult epitopic segment in the third domain. The present study reviews the multiple biological activities of this AFP-derived peptide segment termed the Growth Inhibitory Peptide (GIP), whi...

journal_title：Current protein & peptide science

authors： Mizejewskia GJ,Butterstein G

更新日期：2006-02-01 00:00:00

abstract：:Efforts to use computers in predicting the secondary structure of proteins based only on primary structure information started over a quarter century ago [1-3]. Although the results were encouraging initially, the accuracy of the pioneering methods generally did not attain the level required for using predictions of s...

journal_title：Current protein & peptide science

authors： Heringa J

更新日期：2000-11-01 00:00:00

abstract：:As global resistance to conventional antibiotics rises we need to develop new strategies to develop future novel therapeutics. In our quest to design novel anti-infectives and antimicrobials it is of interest to investigate host-pathogen interactions and learn from the complexity of host defense strategies that have e...

journal_title：Current protein & peptide science

authors： Augustyniak D,Nowak J,Lundy FT

更新日期：2012-12-01 00:00:00

abstract：:Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...

journal_title：Current protein & peptide science

authors： Turra D,Lorito M

更新日期：2011-08-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) represent an emerging class of proteins (or domains) that are characterized by a lack of ordered secondary and tertiary structure. This group of proteins has recently attracted tremendous interest primarily because of a unique feature: they can bind to different targets due to ...

journal_title：Current protein & peptide science

authors： Guo LW,Ruoho AE

更新日期：2008-12-01 00:00:00

abstract：:NOD Like Receptors (NLRs) are the most abundant cytoplasmic immune receptors in plants and animals and they similarly act sensing pathogen invasion and activating immune response. Despite the fact that plant and mammals NLRs share homology.; with some protein structure differences.; for signalling pathway.; divergent ...

journal_title：Current protein & peptide science

authors： Pontillo A,Crovella S

更新日期：2017-01-01 00:00:00

abstract：:Structural and theoretical analyses of proteins are central to the understanding of complex molecular mechanisms and are fundamental to the drug discovery process. Computational techniques yield useful insights into an ever-wider range of biomolecular systems. Protein three-dimensional structures and molecular functio...

journal_title：Current protein & peptide science

authors： Villoutreix BO

更新日期：2002-06-01 00:00:00

abstract：:CGRP and adrenomedullin [AM] are peptides that have a number of physiological effects, including vasodilation, through the activation of a shared GPCR, the family B calcitonin receptor-like receptor [CLR]. Specificity to each ligand is conferred through the unusual association of CLR with a single transmembrane access...

journal_title：Current protein & peptide science

authors： Woolley MJ,Conner AC

更新日期：2013-08-01 00:00:00

abstract：:This work briefly describes available sensors for cAMP and cGMP. Many sensors are based on derivatization of naturally occurring products such as immunoglobulins, protein kinases, etc. Only a few published works deal with chemosensors, which are built up by "total" chemical synthesis. This field stays opened for combi...

journal_title：Current protein & peptide science

authors： Sebestík J,Hlavácek J,Stibor I

更新日期：2005-04-01 00:00:00

abstract：:Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli due to infection and cellular stress have identified to play a vital role in the progr...

journal_title：Current protein & peptide science

authors： Sharma I,Behl T,Bungau S,Sachdeva M,Kumar A,Zengin G,Arora S

更新日期：2020-12-08 00:00:00

abstract：:Mites and ticks are associated with many human diseases including allergic diseases and scabies. With the recent advances in the high throughput DNA sequencing technology, many mitochondrial nuclear genomes of these species have been sequenced and the resulting genomic resources will certainly provide novel insights f...

journal_title：Current protein & peptide science

authors： Xiong Q,Wan ATY,Tsui SK

更新日期：2020-01-01 00:00:00

abstract：:Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages--the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagn...

journal_title：Current protein & peptide science

authors： Singh B,Singh S,Asif AR,Oellerich M,Sharma GL

更新日期：2014-01-01 00:00:00

abstract：:The fluorinated alcohol 2,2,2-Trifluoroethanol (TFE) has been implemented for many decades now in conformational studies of proteins and peptides. In peptides, which are often disordered in aqueous solutions, TFE acts as secondary structure stabilizer and primarily induces an α -helical conformation. The exact mechani...

journal_title：Current protein & peptide science

authors： Vincenzi M,Mercurio FA,Leone M

更新日期：2019-01-01 00:00:00

abstract：:Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive thera...

journal_title：Current protein & peptide science

authors： Lyu C,Fang F,Li B

更新日期：2019-01-01 00:00:00

abstract：:By utilizing recently developed full-length cDNA technologies, large-scale cDNA sequencing was carried out by several cDNA projects. Now full-length cDNA resources cover the major part of the protein-coding human genes. Comprehensive analyses of the collected full-length cDNA data revealed not only the complete sequen...

journal_title：Current protein & peptide science

authors： Suzuki Y,Sugano S

更新日期：2006-04-01 00:00:00

abstract：:Adipose tissue is not only a tissue where energy is stored but is also involved in regulating several body functions such as appetite and energy expenditure via its endocrine activity. Moreover, it thereby modulates complex processes like reproduction, inflammation and immune response. The products secreted from adipo...

journal_title：Current protein & peptide science

authors： Sauerwein H,Bendixen E,Restelli L,Ceciliani F

更新日期：2014-03-01 00:00:00

abstract：:This review is to summarize three new QSAR (quantitative structure-activity relationship) methods recently developed in our group and their applications for drug design. Based on more solid theoretical models and advanced mathematical techniques, the conventional QSAR technique has been recast in the following three a...

journal_title：Current protein & peptide science

authors： Du QS,Huang RB,Chou KC

更新日期：2008-06-01 00:00:00