A Mini-review of the Genomes and Allergens of Mites and Ticks.

abstract：:Pathogenic aggregation is closely associated with various protein misfolding diseases such as type 2 diabetes mellitus and Alzheimer's disease. Amyloidogenic proteins that have a propensity to assemble into amyloid oligomers and fibrils form the aggregates. The tumor suppressor p53, a transcription factor that regulat...

journal_title：Current protein & peptide science

authors： Gong H,Yang X,Zhao Y,Petersen RB,Liu X,Liu Y,Huang K

更新日期：2015-01-01 00:00:00

abstract：:TOYOPEARL particles are cross-linked hydroxylated methacrylic polymers available in different pore and particle sizes. They are conjugated with different ligands to generate ion-exchange, hydrophobic interaction and affinity resins. They have excellent physical and chemical properties. A mixed-mode resin, TOYOPEARL MX...

journal_title：Current protein & peptide science

authors： Arakawa T

更新日期：2019-01-01 00:00:00

abstract：:Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...

journal_title：Current protein & peptide science

authors： Albar AH,Almehdar HA,Uversky VN,Redwan EM

更新日期：2014-01-01 00:00:00

abstract：:The current lack of complete understanding of the pathogenesis of acute kidney injury (AKI) is a significant barrier to its early diagnosis and treatment. Cell cycle arrest plays an important role in the protection of renal tubular epithelial cells and maladaptive repair following AKI. G1 phase cell arrest serves as a...

journal_title：Current protein & peptide science

authors： Wang WG,Sun WX,Gao BS,Lian X,Zhou HL

更新日期：2017-01-01 00:00:00

abstract：:The complement system is a major effector arm of the immune defense contributing to the destruction of invading pathogens. There are three possible routes of complement cascade activation: the classical, the alternative and the lectin pathways. The activation of the classical and lectin pathways is initiated by supram...

journal_title：Current protein & peptide science

authors： Gál P,Ambrus G

更新日期：2001-03-01 00:00:00

abstract：:NOD Like Receptors (NLRs) are the most abundant cytoplasmic immune receptors in plants and animals and they similarly act sensing pathogen invasion and activating immune response. Despite the fact that plant and mammals NLRs share homology.; with some protein structure differences.; for signalling pathway.; divergent ...

journal_title：Current protein & peptide science

authors： Pontillo A,Crovella S

更新日期：2017-01-01 00:00:00

abstract：:Glycoconjugates comprise a variety of structures, include glycoproteins and glycolipids and are found on the surfaces of animal and plant cells, as well as on the surface of microorganisms. Determination of the structure and the distribution of glycoconjugates on cell surfaces are important for the understanding their...

journal_title：Current protein & peptide science

authors： Naeem A,Saleemuddin M,Khan RH

更新日期：2007-06-01 00:00:00

abstract：:The affinity tags are unique proteins/peptides that are attached at the N- or C-terminus of the recombinant proteins. These tags help in protein purification. Additionally, some affinity tags also serve a dual purpose as solubility enhancers for challenging protein targets. By applying a combinatorial approach, carefu...

journal_title：Current protein & peptide science

authors： Mishra V

更新日期：2020-01-01 00:00:00

abstract：:While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now recognized, deciphering their molecular mode of action at the structural level still remains highly challenging and requires a combination of many biophysical approaches. Among them, small angle X-ray scattering (SAXS) has been...

journal_title：Current protein & peptide science

authors： Receveur-Brechot V,Durand D

更新日期：2012-02-01 00:00:00

abstract：:This article is a continuation of a series of reviews on the presence and the role of intrinsic disorder in milk proteins in the journal of Current Protein and Peptide Science. The focus of this article is on casein phosphopeptides, which are liberated during digestion of the milk protein casein. Structurally these ph...

journal_title：Current protein & peptide science

authors： Naqvi MA,Irani KA,Katanishooshtari M,Rousseau D

更新日期：2016-01-01 00:00:00

abstract：:Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...

journal_title：Current protein & peptide science

authors： Wong JH,Xia L,Ng TB

更新日期：2007-10-01 00:00:00

abstract：:Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-cysteinylglycine and the predominant intracellular antioxidant in many organisms including humans. GSH and associated enzymes are controlled by a transcription factor-nuclear factor-2 related erythroid factor-2 (Nrf2). In cellular milieu, GSH p...

journal_title：Current protein & peptide science

authors： Narayanankutty A,Job JT,Narayanankutty V

更新日期：2019-01-01 00:00:00

abstract：:STATs promote fundamental cellular processes, marking them as convergence points of many oncogenic and inflammatory pathways. Therefore, aberrant activation of STAT signaling is implicated in a plethora of human diseases, like cancer, inflammation and auto-immunity. Identification of STAT-specific inhibitors is the to...

journal_title：Current protein & peptide science

authors： Szelag M,Wesoly J,Bluyssen HA

更新日期：2016-01-01 00:00:00

abstract：:Tic, short for 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, is a kind of unnatural α-amino acids. Due to its distinct geometrical conformation and biological activity, the structure of Tic, regarded as the surrogate of proline and the rigid analogue of phenylalanine or tyrosine, has been introduced into many comp...

journal_title：Current protein & peptide science

authors： Zhang Y,Fang H,Xu W

更新日期：2010-12-01 00:00:00

abstract：:Significant differences in function have been observed among lectins structurally similar to concanavalin A, but their high homology with this widely used lectin has kept them in obscurity. The observation of large differences in the potency of many of these Diocleinae lectins as stimulators of Interferon-g production...

journal_title：Current protein & peptide science

authors： Cavada BS,Barbosa T,Arruda S,Grangeiro TB,Barral-Netto M

更新日期：2001-06-01 00:00:00

abstract：:The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensivel...

journal_title：Current protein & peptide science

authors： Liu Y,Liu S,Zhang X,Liang X,Zahid KR,Liu K,Liu J,Deng L,Yang J,Qi C

更新日期：2016-01-01 00:00:00

abstract：:The plasma membrane Ca2+ ATPases (PMCAs) are responsible for the clearance of Ca2+ out of cells after intracellular Ca2+ transients. Cooperating with Na+/Ca2+ exchangers (NCXs) and Ca2+ buffering proteins, PMCAs play an essential role in maintaining the long-term cellular Ca2+ homeostasis. The plasma membrane Ca2+ ATP...

journal_title：Current protein & peptide science

authors： Wu X,Weng L,Zhang J,Liu X,Huang J

更新日期：2018-01-01 00:00:00

abstract：:Staphylococcus aureus is a major cause of infection in humans and animals, causing a wide variety of diseases, from local inflammations to fatal sepsis. The bacterium is commonly multi-drug resistant and thus many front-line antibiotics have been rendered ineffective for treating such infections. Research on murein/pe...

journal_title：Current protein & peptide science

authors： Keary R,Sanz-Gaitero M,van Raaij MJ,O'Mahony J,Fenton M,McAuliffe O,Hill C,Ross RP,Coffey A

更新日期：2016-01-01 00:00:00

abstract：:Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...

journal_title：Current protein & peptide science

authors： Dürvanger Z,Harmat V

更新日期：2019-01-01 00:00:00

abstract：:The structure and stability of apolipoprotein (apo)A-I, the major apolipoprotein of human plasma high-density lipoproteins (HDL), determine the efficiency of the protein in the process of HDL generation and affect HDL properties in binding and exchanging its constituents, thus playing an essential role in reverse chol...

journal_title：Current protein & peptide science

authors： Dergunov AD,Garaeva EA,Savushkin EV,Litvinov DY

更新日期：2017-01-01 00:00:00

abstract：:The bioactive peptides are protein fragments which have a positive impact on the intestinal homeostasis. Intestinal homeostasis depends on the diverse functions of intestinal barrier including the microbiological, physical, chemical and immunological barriers. Defects in intestinal barrier function are associated with...

journal_title：Current protein & peptide science

authors： Ji J,Qu H,Shu D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Drug-Target Interactions (DTI) play a crucial role in discovering new drug candidates and finding new proteins to target for drug development. Although the number of detected DTI obtained by high-throughput techniques has been increasing, the number of known DTI is still limited. On the other hand, the exper...

journal_title：Current protein & peptide science

authors： Huang YA,You ZH,Chen X

更新日期：2018-01-01 00:00:00

abstract：:Allergen-specific Immunotherapy (AIT), through repetitive subcutaneous or sublingual administrations of allergen extracts, represents up to now the unique treatment against allergic sensitizations. However, the clinical efficacy of AIT can be largely dependent on the quality of natural allergen extracts. Moreover, the...

journal_title：Current protein & peptide science

authors： Jacquet A

更新日期：2020-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) represent an emerging class of proteins (or domains) that are characterized by a lack of ordered secondary and tertiary structure. This group of proteins has recently attracted tremendous interest primarily because of a unique feature: they can bind to different targets due to ...

journal_title：Current protein & peptide science

authors： Guo LW,Ruoho AE

更新日期：2008-12-01 00:00:00

abstract：:The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of pro...

journal_title：Current protein & peptide science

authors： Veljkovic N,Glisic S,Prljic J,Perovic V,Botta M,Veljkovic V

更新日期：2008-10-01 00:00:00

abstract：:Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive thera...

journal_title：Current protein & peptide science

authors： Lyu C,Fang F,Li B

更新日期：2019-01-01 00:00:00

abstract：:Dietary protein from fermented cottonseed meal (FCSM), widely used in poultry diets in China, had regulating effects on lipid metabolism. To understand the effects of FCSM on lipid metabolism in broilers, we analyzed the biochemical indexes, enzyme activity, hormone level and metabolites in serum responses to FCSM int...

journal_title：Current protein & peptide science

authors： Nie C,Wang Y,Liu Y,Liu J,Ge W,Ma X,Zhang W

更新日期：2020-01-01 00:00:00

abstract：:Biogenic amines in the gastrointestinal tract are important metabolites of dietary protein and amino acids with the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of bioge...

journal_title：Current protein & peptide science

authors： Fan P,Song P,Li L,Huang C,Chen J,Yang W,Qiao S,Wu G,Zhang G,Ma X

更新日期：2017-01-01 00:00:00

abstract：:Poly-N-acetyllactosamine structures occur in mammalian glycoproteins in both N- and O-linked glycans. They represent a backbone for additional modifications by fucosyltransferases, sialyltransferases and sulfotransferases. These glycans have been suggested to be involved in biospecific interactions with selectins and ...

journal_title：Current protein & peptide science

authors： Zhou D

更新日期：2003-02-01 00:00:00

abstract：:An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allerg...

journal_title：Current protein & peptide science

authors： Jeon SH

更新日期：2020-01-01 00:00:00