The Plasma Membrane Calcium ATPases in Calcium Signaling Network.

Abstract:

:The plasma membrane Ca2+ ATPases (PMCAs) are responsible for the clearance of Ca2+ out of cells after intracellular Ca2+ transients. Cooperating with Na+/Ca2+ exchangers (NCXs) and Ca2+ buffering proteins, PMCAs play an essential role in maintaining the long-term cellular Ca2+ homeostasis. The plasma membrane Ca2+ ATPase was first discovered in red blood cell membrane about 50 years ago, and then other PMCA isoforms and alternatively spliced variants had been identified from different tissues and different developmental stages, revealing a surprising complexity of the PMCA family. In mammals, there are four PMCA isoforms encoded by four distinct genes. Isoform 1 and 4 are found in virtually all tissues, whereas isoform 2 and 3 are primarily expressed in excitable cells such as neurons and myocytes. Perturbation of PMCAs function has been implicated in a variety of diseases and disorders, including hearing loss, ataxia, paraplegia, and infertility. Here, we would like to review the recent progresses in the study of the PMCAs and related disorders, in particular how these pathological conditions help us to gain an in-depth insight into the function of PMCAs and their contribution in the regulation of Ca2+ signaling network.

journal_name

Curr Protein Pept Sci

authors

Wu X,Weng L,Zhang J,Liu X,Huang J

doi

10.2174/1389203719666180416122745

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

813-822

issue

8

eissn

1389-2037

issn

1875-5550

pii

CPPS-EPUB-89739

journal_volume

19

pub_type

杂志文章,评审
  • Understanding the role of Inflammasome in Angina Pectoris.

    abstract::Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli due to infection and cellular stress have identified to play a vital role in the progr...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章

    doi:10.2174/1389203721999201208200242

    authors: Sharma I,Behl T,Bungau S,Sachdeva M,Kumar A,Zengin G,Arora S

    更新日期:2020-12-08 00:00:00

  • Disorder in Milk Proteins: Formation, Structure, Function, Isolation and Applications of Casein Phosphopeptides.

    abstract::This article is a continuation of a series of reviews on the presence and the role of intrinsic disorder in milk proteins in the journal of Current Protein and Peptide Science. The focus of this article is on casein phosphopeptides, which are liberated during digestion of the milk protein casein. Structurally these ph...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203717666151201191658

    authors: Naqvi MA,Irani KA,Katanishooshtari M,Rousseau D

    更新日期:2016-01-01 00:00:00

  • Two Elution Mechanisms of MEP Chromatography.

    abstract::MEP (mercapto-ethyl-pyridine) HyperCel is one of the hydrophobic charge induction chromatography (HCIC) resins. Under normal operation, proteins are bound to the MEP resin at neutral pH, at which MEP is not charged, mostly via hydrophobic interaction. MEP has a pyridine group, whose pK is 4.8, and hence is positively ...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203718666171117105132

    authors: Arakawa T,Tokunaga M,Maruyama T,Shiraki K

    更新日期:2019-01-01 00:00:00

  • Using the telobox to search for plant telomere binding proteins.

    abstract::Telobox is a Myb-related DNA-binding domain which is present in a number of yeast, plant and animal proteins. Its capacity to bind preferentially double-stranded telomeric DNA has been used in numerous studies to search for candidate telomeric proteins in various organisms, including plants. Here we provide an overvie...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920311795684968

    authors: Peška V,Schrumpfová PP,Fajkus J

    更新日期:2011-03-01 00:00:00

  • Glycoprotein targeting and other applications of lectins in biotechnology.

    abstract::Glycoconjugates comprise a variety of structures, include glycoproteins and glycolipids and are found on the surfaces of animal and plant cells, as well as on the surface of microorganisms. Determination of the structure and the distribution of glycoconjugates on cell surfaces are important for the understanding their...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920307780831811

    authors: Naeem A,Saleemuddin M,Khan RH

    更新日期:2007-06-01 00:00:00

  • Small open reading frames: current prediction techniques and future prospect.

    abstract::Evidence is accumulating that small open reading frames (sORF, <100 codons) play key roles in many important biological processes. Yet, they are generally ignored in gene annotation despite they are far more abundant than the genes with more than 100 codons. Here, we demonstrate that popular homolog search and codon-i...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920311796957667

    authors: Cheng H,Chan WS,Li Z,Wang D,Liu S,Zhou Y

    更新日期:2011-09-01 00:00:00

  • Mapping of the active site of proteases in the 1960s and rational design of inhibitors/drugs in the 1990s.

    abstract::For several decades the specificity of proteases has been presented as an active site divided into subsites, using the nomenclature of Schechter & Berger from 1967 (S1, S2... for subsites of the active site; P1, P2... for residues of the substrate occupying the corresponding subsites). At early stages of the research ...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920305774933286

    authors: Schechter I

    更新日期:2005-12-01 00:00:00

  • Suppression of virulence of Porphyromonas gingivalis by potent inhibitors specific for gingipains.

    abstract::Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is implicated as a major etiologic agent of adult periodontal disease. This bacterium is asaccharolytic and possesses strong potency for proteolysis. It produces a novel class of cysteine proteinases, termed gingipains, in the cell-associated and sec...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203033486992

    authors: Kadowaki T,Yamamoto K

    更新日期:2003-12-01 00:00:00

  • Structure and Function of CW Domain Containing Proteins.

    abstract::The CW domain is a zinc binding domain, composed of approximately 50- 60 amino acid residues with four conserved cysteine (C) and two to four conserved tryptophan (W) residues. The members of the superfamily of CW domain containing proteins, comprised of 12 different eukaryotic nuclear protein families, are extensivel...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203717666160125115130

    authors: Liu Y,Liu S,Zhang X,Liang X,Zahid KR,Liu K,Liu J,Deng L,Yang J,Qi C

    更新日期:2016-01-01 00:00:00

  • Structural Diversity in Calmodulin - Peptide Interactions.

    abstract::Calmodulin (CaM) is a highly conserved eukaryotic Ca2+ sensor protein that is able to bind a large variety of target sequences without a defined consensus sequence. The recognition of this diverse target set allows CaM to take part in the regulation of several vital cell functions. To fully understand the structural b...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203720666190925101937

    authors: Dürvanger Z,Harmat V

    更新日期:2019-01-01 00:00:00

  • Regulatory Functions of Fatty Acids with Different Chain Lengths on the Intestinal Health in Pigs and Relative Signaling Pathways.

    abstract::Intestines are not only major organs for nutrient digestion and absorption, but are also the largest immune organ in pigs. They are essential for maintaining the health and growth of piglets. Fatty acids, including short-chain fatty acids, medium-chain fatty acids, and long-chain polyunsaturated fatty acids, are impor...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203720666190514120023

    authors: Chen J,Li Y,Tang Z,Sun Z

    更新日期:2019-01-01 00:00:00

  • Structural bioinformatics: methods, concepts and applications to blood coagulation proteins.

    abstract::Structural and theoretical analyses of proteins are central to the understanding of complex molecular mechanisms and are fundamental to the drug discovery process. Computational techniques yield useful insights into an ever-wider range of biomolecular systems. Protein three-dimensional structures and molecular functio...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203023380657

    authors: Villoutreix BO

    更新日期:2002-06-01 00:00:00

  • About TFE: Old and New Findings.

    abstract::The fluorinated alcohol 2,2,2-Trifluoroethanol (TFE) has been implemented for many decades now in conformational studies of proteins and peptides. In peptides, which are often disordered in aqueous solutions, TFE acts as secondary structure stabilizer and primarily induces an α -helical conformation. The exact mechani...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203720666190214152439

    authors: Vincenzi M,Mercurio FA,Leone M

    更新日期:2019-01-01 00:00:00

  • A review of defensins of diverse origins.

    abstract::Defensins are a family of peptides with potent antimicrobial activity. They are found in various organisms. The intent of this article is to review the structures and mechanisms of antimicrobial actions of defensins produced by different organisms including humans, other mammals, birds, reptiles, fish, mollusks, arthr...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920307782411446

    authors: Wong JH,Xia L,Ng TB

    更新日期:2007-10-01 00:00:00

  • Toll-like receptors: sensor molecules for detecting damage to the nervous system.

    abstract::Toll-like receptors (TLRs) are type I transmembrane signaling molecules that are expressed in cells of the innate immune system. In these cells, TLRs function as pattern recognition receptors (PRR) that recognize specific molecular patterns derived from microorganisms. Upon activation, TLRs trigger a cascade of intrac...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203711314010006

    authors: Lee H,Lee S,Cho IH,Lee SJ

    更新日期:2013-02-01 00:00:00

  • Drug-Target Interactions: Prediction Methods and Applications.

    abstract::Identifying the interactions between drugs and target proteins is a key step in drug discovery. This not only aids to understand the disease mechanism, but also helps to identify unexpected therapeutic activity or adverse side effects of drugs. Hence, drug-target interaction prediction becomes an essential tool in the...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203718666161108091609

    authors: Anusuya S,Kesherwani M,Priya KV,Vimala A,Shanmugam G,Velmurugan D,Gromiha MM

    更新日期:2018-01-01 00:00:00

  • Construction of macromolecular assemblages in eukaryotic processes and their role in human disease: linking RINGs together.

    abstract::Members of the Really Interesting New Gene (RING) family of proteins are found throughout the cells of eukaryotes and function in processes as diverse as development, oncogenesis, viral replication and apoptosis. There are over 200 members of the RING family where membership is based on the presence of a consensus seq...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章

    doi:10.2174/1389203003381478

    authors: Kentsis A,Borden KL

    更新日期:2000-07-01 00:00:00

  • Predicting the melting point of human C-type lysozyme mutants.

    abstract::A complete understanding of the relationships between protein structure and stability remains an open problem. Much of our insight comes from laborious experimental analyses that perturb structure via directed mutation. The glycolytic enzyme lysozyme is among the most well characterized proteins under this paradigm, d...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章

    doi:10.2174/138920310794109210

    authors: Verma D,Jacobs DJ,Livesay DR

    更新日期:2010-11-01 00:00:00

  • Transcriptome analyses of human genes and applications for proteome analyses.

    abstract::By utilizing recently developed full-length cDNA technologies, large-scale cDNA sequencing was carried out by several cDNA projects. Now full-length cDNA resources cover the major part of the protein-coding human genes. Comprehensive analyses of the collected full-length cDNA data revealed not only the complete sequen...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920306776359795

    authors: Suzuki Y,Sugano S

    更新日期:2006-04-01 00:00:00

  • Multi-faceted arginine: mechanism of the effects of arginine on protein.

    abstract::Arginine is widely used in such applications as protein refolding, solubilization of proteins and small molecules, protein and small molecule formulation, column chromatography and viral inactivation as summarized in this review. What makes arginine effective in these applications is largely based on its ability to su...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920371506140818113015

    authors: Arakawa T,Kita Y

    更新日期:2014-01-01 00:00:00

  • Cathelicidins: peptides with antimicrobial, immunomodulatory, anti-inflammatory, angiogenic, anticancer and procancer activities.

    abstract::The family of peptides designated as cathelicidins was identified over a decade ago. Cathelicidins have since gained increasing recognition, both as endogenous antibiotics and as effector molecules of the innate immune system. The human cathelicidin LL-37 is widely expressed in human tissues and plays diverse biologic...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/13892037113149990067

    authors: Wong JH,Ye XJ,Ng TB

    更新日期:2013-09-01 00:00:00

  • System Bioinformatic Approach Through Molecular Docking, Network Pharmacology and Microarray Data Analysis to Determine the Molecular Mechanism Underlying the Effects of Rehmanniae Radix Praeparata on Cardiovascular Diseases.

    abstract::Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Rehmanniae Radix Praeparata (RRP) is a popular medicinal herb widely used in traditional Chinese medicine (TCM) to treat CVDs. However, the development of this novel therapeutic product has been stagnant, and its molecular mechanism of action...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章

    doi:10.2174/1389203720666190610161535

    authors: Zhang X,Wang D,Ren X,Atanasov AG,Zeng R,Huang L

    更新日期:2019-01-01 00:00:00

  • Biological significance of polymorphism in legume protease inhibitors from the Bowman-Birk family.

    abstract::Naturally occurring protease inhibitors (PI) of the Bowman-Birk type constitute a major PI family in cereal and legume seeds. The family name is derived from the names of the two investigators who characterised the first inhibitor of this type, the Bowman-Birk inhibitor from soybean (BBI). These proteins have the capa...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920306777452349

    authors: Clementea A,Domoney C

    更新日期:2006-06-01 00:00:00

  • Non-Allosteric Cooperativity in Hemoglobin.

    abstract::Hemoglobin (Hb) is the prototypical example of a cooperative protein. Cooperativity of Hb is largely accounted for by the oxygen-linked allosteric interconversion between the T and R states/structures. Allostery is such a powerful explanation of Hb cooperativity that the possibility of cooperative events occurring wit...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203718666171030103310

    authors: Bellelli A

    更新日期:2018-01-01 00:00:00

  • Potato type I and II proteinase inhibitors: modulating plant physiology and host resistance.

    abstract::Serine protease inhibitors (PIs) are a large and complex group of plant proteins. Members of the potato type I (Pin1) and II (Pin2) proteinase inhibitor families are among the first and most extensively characterized plant PIs. Many insects and phytopathogenic microorganisms use intracellular and extracellular serine ...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920311796391151

    authors: Turra D,Lorito M

    更新日期:2011-08-01 00:00:00

  • Cardioprotective peptides from marine sources.

    abstract::Elevated blood pressure or hypertension is one of the fastest growing health problems worldwide. Although the etiology of essential hypertension has a genetic component, dietary factors play an important role. With the high costs and adverse side-effects associated with synthetic antihypertensive drugs and the awarene...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/13892037113149990036

    authors: Harnedy PA,FitzGerald RJ

    更新日期:2013-05-01 00:00:00

  • Structural heterogeneity and multifunctionality of lactoferrin.

    abstract::Lactoferrin or lactotransferrin is a multifunctional glycoprotein found in blood circulation, mucosal surfaces, neutrophils, and in various secretory fluids, such as milk, bile, tears, nasal secretion, pancreatic juice, and saliva. The lactoferrin content in milk varies between different mammalian species and, within ...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/1389203715666140919124530

    authors: Albar AH,Almehdar HA,Uversky VN,Redwan EM

    更新日期:2014-01-01 00:00:00

  • Recent advances in QSAR and their applications in predicting the activities of chemical molecules, peptides and proteins for drug design.

    abstract::This review is to summarize three new QSAR (quantitative structure-activity relationship) methods recently developed in our group and their applications for drug design. Based on more solid theoretical models and advanced mathematical techniques, the conventional QSAR technique has been recast in the following three a...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920308784534005

    authors: Du QS,Huang RB,Chou KC

    更新日期:2008-06-01 00:00:00

  • Prediction of number and position of domain boundaries in multi-domain proteins by use of amino acid sequence alone.

    abstract::Prediction of protein domain boundaries is an important step for the prediction of three-dimensional structure. The simple method PDP has been elaborated for prediction of the number and position of domain boundaries in multi-domain proteins by use of amino acid sequence alone. The method uses an optimized scale based...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章,评审

    doi:10.2174/138920307780363460

    authors: Dovidchenko NV,Lobanov MY,Galzitskaya OV

    更新日期:2007-04-01 00:00:00

  • A Systematic Prediction of Drug-Target Interactions Using Molecular Fingerprints and Protein Sequences.

    abstract:BACKGROUND:Drug-Target Interactions (DTI) play a crucial role in discovering new drug candidates and finding new proteins to target for drug development. Although the number of detected DTI obtained by high-throughput techniques has been increasing, the number of known DTI is still limited. On the other hand, the exper...

    journal_title:Current protein & peptide science

    pub_type: 杂志文章

    doi:10.2174/1389203718666161122103057

    authors: Huang YA,You ZH,Chen X

    更新日期:2018-01-01 00:00:00