当前位置： SCI文献检索 > Journal of the Mechanical Behavior of Biomedical Materials期刊下所有文献 > Development and characterization of cross-linked gellan gum and retrograded starch blend hydrogels for drug delivery applications.

Development and characterization of cross-linked gellan gum and retrograded starch blend hydrogels for drug delivery applications.

Abstract：

:The retrogradation of high amylose starch (5% or 10%), by isothermal cycles at 4°C (method 1) or by alternating thermal cycles (method 2) was efficient and promoted important structural modifications. Hydrogels of gellan gum and starch retrograded blends, containing or not ketoprofen, were prepared by ionic and dual cross-linking, at different concentrations of polymer and cross-linkers, and characterized by texture and rheological analysis, X-ray diffraction and morphological analysis. The ionic cross-linking and starch retrograded by method 1 contributed to the improvement of hardness and cohesiveness of hydrogels while the dual cross-linking and starch retrograded by method 2 favored the adhesiveness. The rising of polymer concentration lead to the improvement of all mechanical parameters. Rheological data demonstrated that non-cross-linked dispersions showed a behavior of weak gels and the cross-linked hydrogels presented a predominantly elastic behavior (G'≫G″), peculiar of strong gels. X-ray diffraction, rheological data and the scanning electron microscopy (FEG-SEM) revealed that the increase of polymers and cross-linkers concentration and the presence of drug resulted in stronger and more stable tridimensional structures. The suitable adhesiveness and high strength and elasticity of hydrogels H253IC-KT, H255IC-KT, H21053DC-KT and H21055DC-KT make them more promising materials for the design of mucoadhesive drug delivery systems.

journal_name

J Mech Behav Biomed Mater

journal_title

Journal of the mechanical behavior of biomedical materials

authors

Oliveira Cardoso VM,Stringhetti Ferreira Cury B,Evangelista RC,Daflon Gremião MP

doi

10.1016/j.jmbbm.2016.08.005

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

317-333

eissn

1751-6161

issn

1878-0180

pii

S1751-6161(16)30262-4

journal_volume

65

pub_type

杂志文章

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