Abstract：
:We previously described the gelation mechanism of calcium polyphosphate (CPP) in the presence of water. In this study, we developed novel and injectable poly-dicalcium phosphate dihydrate (P-DCPD) forming cement by the reaction of acidic CPP gel with alkali tetracalcium phosphate (TTCP). The setting reaction mechanism of P-DCPD is due to the intermolecular interaction between CPP gel and TTCP that was supported by XRD, AFM, Raman spectra analysis and SEM. The setting mechanism of P-DCPD is completely different from the classical calcium phosphate cement (CPC) that achieves crystallization by monophosphates reaction. P-DCPD represents a new type of poly-CPCs with significant advantages, including strong mechanical strength, excellent cohesion and easy of handling. More extensive experiments are currently underway to further evaluate the performance of P-DCPD cements, including biocompatibility, degradation behavior and bone defect hearing efficacy, among others.
journal_name
J Mech Behav Biomed Materauthors
Ren W,Song W,Yurgelevic S,Markel DCdoi
10.1016/j.jmbbm.2017.12.032subject
Has Abstractpub_date
2018-03-01 00:00:00pages
226-234eissn
1751-6161issn
1878-0180pii
S1751-6161(17)30588-Xjournal_volume
79pub_type
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