Abstract：
:With the aim to prepare antibacterial acrylic bone cements, a series of imidazolium-containg mono-methacrylates with N-alkyl chain length varied from 10 to 18 (MEIM-x) were synthesized as polymerizable antibacterial agents through a two-step reaction. The structures of the monomers were confirmed by 1H NMR. Methyl methacrylate in the liquid compoent of cements was partially replaced by MEIM-x to prepare bone cements with 5wt% of MEIM-x. Properties of prepared cements like antibacterial activity, doughing time, curing parameters including maximum temperature (Tmax) and setting time (tset), flexual strength (FS) and modulus (FM), compressive strength (CS) and fluid uptake (FU) in Ringer's solution were investigated. Acrylic bone cement without any MEIM-x was used as control. Compared with the control cement, MEIM-x-containing cements had shorter doughing time, lower Tmax, same or longer tset, and higher FU. Though MEIM-x could endow cements with strong antibacterial activity, it could reduce mechanical properties of bone cements. Therefore, further study should be taken to optimize the content of MEIM-x in cement which could supply sufficient antibacterial activity and maintain mechanical performance.
journal_name
J Mech Behav Biomed Materauthors
Zhu W,Liu F,He Jdoi
10.1016/j.jmbbm.2017.06.003subject
Has Abstractpub_date
2017-10-01 00:00:00pages
176-182eissn
1751-6161issn
1878-0180pii
S1751-6161(17)30240-0journal_volume
74pub_type
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