Abstract：
:Tonometers are intended to determine the intraocular pressure (IOP) and the quality of corneal tissue. In contrast to the physiological state of stress of the cornea, tonometers induce non-physiological bending stress. Recently, the use of a single experiment to calibrate a set of corneal mechanical properties was suggested to be an ill-posed problem. Thus, we propose a numerical-experimental protocol that uses inflation and indentation experiments simultaneously, restricting the optimization space to circumvent the ambiguity of the fitting. For the first time, both corneal behaviors, i.e., biaxial tension (physiological) and bending (non-physiological), are taken into account. The experimental protocol was performed using an animal model (New Zealand rabbit's cornea). The patient-specific geometry and IOP were registered using a MODI topographer (CSO, Italy) and an applanation tonometer, respectively. The mechanical response was evaluated using inflation and indentation experiments. Subsequently, the optimal set of material properties is identified via an inverse finite element method. To validate the methodology, an in vivo incisional refractive surgery (astigmatic keratotomy, AK) is performed on four animals. The optical outcomes showed a good agreement between the real and simulated surgeries, indicating that the protocol can provide a reliable set of mechanical properties that enables further applications and simulations. After a reliable ex vivo database of inflation experiments is built, our protocol could be extended to humans.
journal_name
J Mech Behav Biomed Materauthors
Ariza-Gracia MÁ,Ortillés Á,Cristóbal JÁ,Rodríguez Matas JF,Calvo Bdoi
10.1016/j.jmbbm.2017.06.017subject
Has Abstractpub_date
2017-10-01 00:00:00pages
304-314eissn
1751-6161issn
1878-0180pii
S1751-6161(17)30256-4journal_volume
74pub_type
杂志文章abstract：:Brazil nut (Bertholletia excelsa) fruits are capable of resisting high mechanical forces when released from trees as tall as 50 m, as well as during animal dispersal by sharp-teethed rodents. Thick mesocarp plays a crucial part in seed protection. We investigated the role of microstructure and how sclereids, fibers, a...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.104306
更新日期：2021-01-07 00:00:00
abstract：:A newly designed hydroxyapatite-polyurethane (HA-PU) composite scaffold was prepared by polymerizing glyceride of castor oil (GCO) with isophorone diisocyanate (IPDI) and HA as fillers. The aim of this study was to determine the effect of HA fillers on the mechanical properties and osteogenesis capacity of the composi...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.08.028
更新日期：2018-12-01 00:00:00
abstract：:This review attempts to show the bone community that there are many ways of being a 'bone', and that the range of mechanical properties of bone material is much greater than is conventionally thought to be the case. However the structure-function relationships have in many cases hardly moved beyond mere assertion. The...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章,评审
doi：10.1016/j.jmbbm.2010.03.002
更新日期：2010-07-01 00:00:00
abstract：:The incorporation of functional monomers and proteolytic inhibitors into adhesive systems have shown to be promising strategies to improve the longevity of adhesive restorations. The aim of this study was to evaluate the long-term bonding performance and anti-gelatinolytic effect of a 10-MDP-based universal adhesive s...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103925
更新日期：2020-10-01 00:00:00
abstract：:Considering the interest of the research community in the fatigue behavior of all-ceramic restorations and the time consumed in low-frequency cyclic fatigue tests, this study aimed to investigate the influence of the loading frequency on the zirconia fatigue strength. The biaxial flexural fatigue strength of Y-TZP dis...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.01.008
更新日期：2016-08-01 00:00:00
abstract：:The fabrication of the workhorse Ti-6Al-4V alloy and of the Ti-3Al-2.5V alloy was studied considering the master alloy addition variant of the blending elemental approach conventionally used for titanium powder metallurgy. The powders were characterised by means thermal analysis and X-ray diffraction and shaped by mea...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.05.019
更新日期：2012-11-01 00:00:00
abstract：:Deep vein thrombosis, pulmonary embolism, and abdominal aortic aneurysms are blood-related diseases that represent a major public health problem. These diseases are characterized by the formation of a thrombus (i.e., blood clot) that either blocks a major artery or causes an aortic rupture. Identifying the mechanical ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.02.012
更新日期：2012-06-01 00:00:00
abstract：:The incidence of total hip arthroplasty (THA) has been evidently growing over the last few decades. Surface modification, such as polymer grafting onto implant surfaces using poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC), has been gaining attention due to its excellent biocompatibility and high lubricity beha...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2019.103412
更新日期：2019-12-01 00:00:00
abstract：:The mechanical reliability of calcium phosphate cements has restricted their clinical application in load-bearing locations. Although their mechanical strength can be improved using a variety of strategies, their fatigue properties are still unclear, especially after degradation. The evolutions of uniaxial compressive...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.07.026
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVES:The study investigated the effects of novel prime-&-rinse mode using MDP (10-methacryloyloxydecyl dihydrogenphosphate) and matrix metalloproteinase (MMPs) inhibitors on dentin microtensile bond strengths (MTBS) of self-etch adhesive, resin-dentin interface degradations, and activity of recombinant human (rh)...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103698
更新日期：2020-04-01 00:00:00
abstract：:A modified split Hopkinson tension bar (SHTB) apparatus was used to investigate the dynamic tensile mechanical response of porcine muscles. A hollow aluminum alloy transmission bar and a semiconductor strain gauge were used to enhance the weak signal from porcine muscles. A ring-shaped copper pulse shaper was used to ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.104279
更新日期：2021-03-01 00:00:00
abstract：:This study describes the synthesis of Al(2)O(3)/SiC/ZrO(2) functionally graded material (FGM) in bio-implants (artificial joints) by electrophoretic deposition (EPD). A suitable suspension that was based on 2-butanone was applied for the EPD of Al(2)O(3)/SiC/ZrO(2), and a pressureless sintering process was applied as ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.02.029
更新日期：2012-08-01 00:00:00
abstract：:This work deals with the mechanical characterization by depth-sensing indentation (DSI) of PLLA and PLDA composites reinforced with micro-particles of Mg (up to 15wt%), which is a challenging task since the indented volume must provide information of the bulk composite, i.e. contain enough reinforcement particles. The...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.09.013
更新日期：2017-01-01 00:00:00
abstract：:Tissue engineering technology requires porous scaffolds, based on biomaterials, which have to mimic as closely as possible the morphological and anisotropic mechanical properties of the native tissue to substitute. Anisotropic fibrous scaffolds fabricated by template-assisted electrospinning are investigated in this s...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.104124
更新日期：2021-01-01 00:00:00
abstract：:The aim of this work was to assess the influence of reduction of the apparent mechanical properties of fully load-bearing porous titanium implants used in mandibular bone defects. Segmental 18mm long bone defects were created bilaterally in the lower jaws of adult ewes. One group of 6 ewes (group A) was treated with l...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.02.036
更新日期：2016-06-01 00:00:00
abstract：:Processing scaffolds that mimic the extracellular matrix (ECM) of natural bone in structure and chemical composition is a potential promising option for engineering physiologically functional bone tissue. In this article, we report a novel method, by combining electrospinning and mineralization, to process a series of...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2008.01.007
更新日期：2008-07-01 00:00:00
abstract：:This work is part of an ongoing program to develop a new carbon fiber/flax/epoxy (CF/flax/epoxy) hybrid composite material for use as an orthopaedic long bone fracture plate, instead of a metal plate. The purpose of this study was to evaluate the mechanical properties of this new novel composite material. The composit...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.12.013
更新日期：2013-04-01 00:00:00
abstract：:Biocomposites comprise highly stiff reinforcement elements connected by a compliant matrix material. While the interfacial elastic properties of these biocomposites play a key role in determining the mechanical properties of the entire biocomposite, these properties cannot be measured directly from standard nanomechan...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.104209
更新日期：2021-02-01 00:00:00
abstract：:This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix(™) that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix(™) was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.01.018
更新日期：2015-05-01 00:00:00
abstract：AIM OF THE STUDY:The aim of this study was to evaluate the effect of solvent/disinfectant ethanol on the surface of denture base polymers. Changes in surface roughness, topography and some nanomechanical properties were assessed by SEM and nanoindentation plotted against different concentrations of ethanol on heat cure...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.09.007
更新日期：2016-02-01 00:00:00
abstract：:The microstructure and mechanical properties of as-extruded Mg-8Y-1Er-2Zn (wt%) alloy containing long period stacking ordered (LPSO) phase are comparatively investigated before and after corrosion in a simulated body fluid (SBF) at 37°C. The as-extruded alloy consists of a long strip-like 18R-LPSO phase and some fine ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.08.012
更新日期：2013-12-01 00:00:00
abstract：:The lumbar facet capsular ligament (FCL) articulates with six degrees of freedom during spinal motions of flexion/extension, lateral bending, and axial rotation. The lumbar FCL is composed of highly aligned collagen fiber bundles on the posterior surface (oriented primarily laterally between the rigid articular facets...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.08.019
更新日期：2017-01-01 00:00:00
abstract：:Porous scaffolds of Ti-6Al-4V were produced by mixing of this alloy with different amount of magnesium (Mg) powders. The mixtures were compacted in steel die by applying uniaxial pressure of 500 MPa before sintering the compacts in sealed quartz tubes at 900 °C for 2 h. Employing Archimedes׳ principle and Image Tool s...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.04.015
更新日期：2015-08-01 00:00:00
abstract：:Bone is characterized with an optimized combination of high stiffness and toughness. The understanding of bone nanomechanics is critical to the development of new artificial biological materials with unique properties. In this work, the mechanical characteristics of the interfaces between osteopontin (OPN, a noncollag...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.04.002
更新日期：2014-08-01 00:00:00
abstract：:Capsules consist of droplets enclosed by a membrane with shear resistant properties especially when fabricated by interfacial cross-linking. In many applications, the protection and release of the internal medium need to be strictly controlled. It is possible to tune the membrane mechanical properties by changing the ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.09.008
更新日期：2016-05-01 00:00:00
abstract：:Mechanical characterization of the cortex of rectrices (tail feathers) of the Toco Toucan (Ramphastos toco) has been carried out by tensile testing of the rachis cortex in order to systematically determine Young's modulus and maximum tensile strength gradients on the surfaces and along the length of the feather. Of ov...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.01.010
更新日期：2011-07-01 00:00:00
abstract：:The inelastic deformability of the mineralised matrix in bones is critical to their high toughness, but the nanoscale mechanisms are incompletely understood. Antler is a tough bone type, with a nanostructure composed of mineralised collagen fibrils ∼100nm diameter. We track the fibrillar deformation of antler tissue d...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.03.020
更新日期：2013-12-01 00:00:00
abstract：:Severe plastic deformation (SPD) has recently been advanced as the main process for fabricating bulk ultrafine grained or nanocrystalline metallic materials, which present much higher strength and better bio-compatibility than coarse-grained counterparts. Medical devices, such as aneurysm clips and dental implants, re...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.02.002
更新日期：2017-04-01 00:00:00
abstract：:Laser surface melting (LSM) of Ti6Al4V alloy was carried out with an aim to improve properties such as microstructure and wear for implant applications. The alloy substrate was melted at 250W and 400W at a scan velocity of 5mm/s, with input energy of 42J/mm(2) and 68J/mm(2), respectively. The results showed that equia...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.12.001
更新日期：2014-04-01 00:00:00
abstract：:Many biomineralized organisms have evolved highly oriented nanostructures to perform specific functions. One key example is the abrasion-resistant rod-like microstructure found in the radular teeth of Chitons (Cryptochiton stelleri), a large mollusk. The teeth consist of a soft core and a hard shell that is abrasion r...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.03.026
更新日期：2015-08-01 00:00:00
