Abstract:
:A newly designed hydroxyapatite-polyurethane (HA-PU) composite scaffold was prepared by polymerizing glyceride of castor oil (GCO) with isophorone diisocyanate (IPDI) and HA as fillers. The aim of this study was to determine the effect of HA fillers on the mechanical properties and osteogenesis capacity of the composite scaffolds. The physical and biological properties of the scaffold were evaluated by SEM observation, mechanical testing, cell culture and animal experiments. The results showed that HA fillers enhanced the mechanical properties of PU composite scaffolds such as compressive strength and elastic modulus. The mechanical properties of the scaffolds were seen to increase with increase in HA loading. The compressive strength of composite scaffold with 0 wt%, 20 wt%, 40 wt% of HA was 0.6 ± 0.1 MPa, 2.1 ± 0.1 MPa, and 4.6 ± 0.3 MPa, respectively. In vitro biodegradation studies of scaffolds were carried out. The results showed that all of the scaffolds were susceptible to cholesterol esterase (CE) -catalyzed degradation. HA-PU composite scaffolds exhibited a high affinity to osteoblastic cells and were good template for cell growth and proliferation. When implanted in bone defects of rats, PU scaffolds incorporated HA were biocompatible with the tissue host and had no immune rejection. Moreover, the higher the loading of HA in the composite scaffold, the better chances of osteogenesis. It confirmed that the prepared HA-PU composite scaffolds can be promising candidate for bone repair and bone tissue engineering.
journal_name
J Mech Behav Biomed Materauthors
Du J,Zuo Y,Lin L,Huang D,Niu L,Wei Y,Wang K,Lin Q,Zou Q,Li Ydoi
10.1016/j.jmbbm.2018.08.028subject
Has Abstractpub_date
2018-12-01 00:00:00pages
150-159eissn
1751-6161issn
1878-0180pii
S1751-6161(18)30806-3journal_volume
88pub_type
杂志文章abstract::This study assessed the fatigue performance (biaxial flexure fatigue strength), surface characteristics (topography and roughness) and structural stability (t-m phase transformation) of a Y-TZP ceramic subjected to air-abrasion using new powders (7% and 20% silica-coated aluminum oxide particles) in comparison to comm...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.05.032
更新日期:2019-10-01 00:00:00
abstract::Cell seeding of 3D scaffolds is a critical step in tissue engineering since the final tissue properties are related to the initial cell distribution and density within the scaffold unit. Perfusion systems can transport cells to the scaffold however; the fact that cells flow inside the scaffold pores does not guarantee...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.08.003
更新日期:2017-11-01 00:00:00
abstract::An experimental simulation study is made to determine the effects of occlusal wear on the capacity of teeth to resist fracture. Tests are carried out on model dome structures, using glass shells to represent enamel and epoxy filler to represent dentin. The top of the domes are ground and polished to produce flat surfa...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2011.08.028
更新日期:2012-01-01 00:00:00
abstract::The retrogradation of high amylose starch (5% or 10%), by isothermal cycles at 4°C (method 1) or by alternating thermal cycles (method 2) was efficient and promoted important structural modifications. Hydrogels of gellan gum and starch retrograded blends, containing or not ketoprofen, were prepared by ionic and dual c...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.08.005
更新日期:2017-01-01 00:00:00
abstract::This paper presents a new approach to study the effects of temperature on the poro- elastic and viscoelastic behavior of articular cartilage. Biphasic solid-fluid mixture theory is applied to study the poro-mechanical behavior of articular cartilage in a fully saturated state. The balance of linear momentum, mass, and...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.11.023
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the fracture resistance of two-piece zirconia oral implants after long-term thermomechanical cycling in an aqueous environment. Non-loaded samples and a one-piece implant system served as control groups. METHODS:A total of 48 zirconia implants were evaluated: 16 one-piece implants (ATZ; Group A) ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.07.005
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to investigate how water aging of the resin cement influences the stress distribution in all-ceramic crowns and if there is an increase in the propensity for crown failure. The failure of all-ceramic crowns attributed to cement degradation was explored using a combination of experimental ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2012.08.003
更新日期:2013-01-01 00:00:00
abstract::Pressure ulcers (PUs) are common in patients who chronically depend on a wheelchair for mobility, such as those with a spinal cord injury (SCI). In attempt to prevent the formation of PUs, pressure relieving maneuvers, such as push-ups, are commonly recommended for individuals with SCI. However, very little is known a...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.04.015
更新日期:2013-12-01 00:00:00
abstract::Some ultraviolet radiation (UV) is essential to the body as it stimulates the production of vitamin D, yet overexposure has deleterious consequences for the skin. UV induces structural and cellular changes across the different layers of skin tissue leading to mechanical and oxidative stress. Both are critical paramete...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.02.008
更新日期:2013-12-01 00:00:00
abstract::Total Knee Arthroplasty is a well-established surgical procedure performed to relieve pain and to restore function in knee osteoarthritis. A proper choice of the implant size is mandatory in order to guarantee the success of the implant and to respect the bone stock of tibial plateau and femoral condyles. The aim of t...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.06.012
更新日期:2014-10-01 00:00:00
abstract::Effect of solid distribution between edges and vertices of three-dimensional cellular solid with an open-cell structure was investigated both numerically and experimentally. Finite element analysis (FEA) with continuum elements and appropriate periodic boundary condition was employed to calculate the elastic propertie...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.05.018
更新日期:2014-09-01 00:00:00
abstract::Although stenting is the most commonly performed procedure for the treatment of coronary atherosclerotic lesions, in-stent restenosis (ISR) remains one of the most serious clinical complications. An important stimulus to ISR is the altered hemodynamics with abnormal shear stresses on endothelial cells generated by the...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.02.009
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:To test whether the load-bearing capacity of occlusal veneers made of ceramic or hybrid materials bonded to dentin does differ from those of porcelain-fused-to metal or lithium disilicate glass ceramic crowns. MATERIAL AND METHODS:In 80 human molars, occlusal tooth substance was removed so that the defects ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.04.006
更新日期:2019-07-01 00:00:00
abstract::Isolated and packed muscles (e.g. in the calf) exhibit different three-dimensional muscle shapes. In packed muscles, cross-sections are more angular compared to the more elliptical ones in isolated muscles. As far as we know, it has not been examined yet, whether the shape of the muscle in its packed condition influen...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.04.006
更新日期:2018-07-01 00:00:00
abstract::Poly(vinyl) alcohol hydrogel (PVA) is a well-known polymer widely used in the medical field due to its biocompatibility properties and easy manufacturing. In this work, the tribo-mechanical properties of PVA-based blocks are studied to evaluate their suitability as a part of a structure simulating the length scale dep...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.05.001
更新日期:2016-09-01 00:00:00
abstract::Surface finish of NiTi is widely perceived to affect its biocompatibility and corrosion fatigue performance. The aim of this work was to find out, whether a carefully engineered surface oxide shows any beneficial effect over electropolished surface on the fatigue performance of superelastic NiTi wire mechanically cycl...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2020.104028
更新日期:2020-11-01 00:00:00
abstract::The design of meshes for the treatment of incisional hernias could benefit from better knowledge of the mechanical response of the abdominal wall and how this response is affected by the implant. The aim of this study was to characterise the mechanical behaviour of the human abdominal wall. Abdominal walls were tested...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.07.002
更新日期:2014-10-01 00:00:00
abstract::Anterior cruciate ligament (ACL) is a key fibrous connective tissue that maintains the stability of a knee joint and it is the most commonly injured ligament of the knee. A synthetic prosthesis in the form of a braided structure can be an attractive alternative to biological grafts provided that the mechanical propert...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.09.018
更新日期:2016-02-01 00:00:00
abstract::Considering the interest of the research community in the fatigue behavior of all-ceramic restorations and the time consumed in low-frequency cyclic fatigue tests, this study aimed to investigate the influence of the loading frequency on the zirconia fatigue strength. The biaxial flexural fatigue strength of Y-TZP dis...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.01.008
更新日期:2016-08-01 00:00:00
abstract::The use of an adhesive for mesh fixation in hernia repair reduces chronic pain and minimizes tissue damage in the patient. This study was designed to assess the adhesive properties of a medium-chain (n-butyl) cyanoacrylate glue applied as drops or as a spray in a biomechanical and histologic study. Both forms of glue ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.08.008
更新日期:2017-11-01 00:00:00
abstract::The incidence of total hip arthroplasty (THA) has been evidently growing over the last few decades. Surface modification, such as polymer grafting onto implant surfaces using poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC), has been gaining attention due to its excellent biocompatibility and high lubricity beha...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.103412
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of post-curing method, printing layer thickness, and water storage on the mechanical properties and degree of conversion of a light-curing methacrylate based resin material (IMPRIMO® LC Splint), used for the fabrication of 3D printed occlusal splints and surgical guides. METHODS:96 bar...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2020.104254
更新日期:2021-03-01 00:00:00
abstract::Veins have historically been discussed in qualitative, relative terms: "more compliant" than arteries, subject to "lower pressures". The structural and compositional differences between arteries and veins are directly related to the different functions of these vessels. Veins are often used as grafts to reroute flow f...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2009.06.003
更新日期:2010-02-01 00:00:00
abstract::The wear properties of oxidized and non-oxidized gamma-TiAl (a potential biomaterial) as well as Ti-6Al-4V and CP-Ti disks were studied and characterized by means of standard wear tests using a custom made bone pin arrangement. The Ti-based disks were oxidized in air at 500 and 800 degrees C for one hour. The tribolog...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2010.06.006
更新日期:2010-11-01 00:00:00
abstract::The aim of the study was to investigate the effect of post-heat treatment on the microstructures and fatigue strengths of Co-Cr-Mo (CCM) clasps prepared by selective laser melting (SLM). Clasp specimens and rod-shaped specimens were fabricated by SLM using CCM powders with different angulations (0°, 45°, and 90°). Two...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.06.010
更新日期:2019-10-01 00:00:00
abstract::Silk is widely used in the biomedical field (e.g., surgical sutures) for its excellent mechanical properties and biocompatibility. The properties of silk can be further enhanced by a multitude of methods, including nano particle feeding, which is convenient and green. Generally, the filament length of a silkworm cocoo...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2020.104147
更新日期:2021-01-01 00:00:00
abstract::Critically engineered stiffness and strength of a scaffold are crucial for managing maladapted stress concentration and reducing stress shielding. At the same time, suitable porosity and permeability are key to facilitate biological activities associated with bone growth and nutrient delivery. A systematic balance of ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2019.103517
更新日期:2020-02-01 00:00:00
abstract::Biochemical signals related to a mechanosensory mechanism by which cells sense mechanical stimuli have been gradually clarified by biological approaches such as blocking specific signaling pathways; however, mechanical signals such as deformation/strain, which is transduced into biochemical signals through this mechan...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2007.06.003
更新日期:2008-01-01 00:00:00
abstract::Trans femoral amputation is one of the most uncomfortable surgeries in patient׳s life, where the prosthesis consisting of a socket, knee joint, pylon and foot is used to do the walking activities. The artificial prosthetic knee joint imitates the functions of human knee to achieve the flexion-extension for the above k...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.06.002
更新日期:2015-10-01 00:00:00
abstract::The lumbar facet capsular ligament (FCL) articulates with six degrees of freedom during spinal motions of flexion/extension, lateral bending, and axial rotation. The lumbar FCL is composed of highly aligned collagen fiber bundles on the posterior surface (oriented primarily laterally between the rigid articular facets...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.08.019
更新日期:2017-01-01 00:00:00