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Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.

Abstract：

:This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix(™) that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix(™) was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix(™) is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix(™) has already been shown to be an excellent protective coating for new ICP monitoring chip.

journal_name

J Mech Behav Biomed Mater

journal_title

Journal of the mechanical behavior of biomedical materials

authors

Yang J,Charif AC,Puskas JE,Phillips H,Shanahan KJ,Garsed J,Fleischman A,Goldman K,Roy S,Luebbers MT,Dombrowski SM,Luciano MG

doi

10.1016/j.jmbbm.2015.01.018

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

83-9

eissn

1751-6161

issn

1878-0180

pii

S1751-6161(15)00027-2

journal_volume

45

pub_type

杂志文章

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